The Effect of the Interventions on Basic Knowledge of and Skills of Health Care Workers in the Preparation of Cytotoxic Drugs at Sappasithiprasong Hospital, Ubon Ratchathani Province
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Abstract
The study aimed to evaluate the effects of the interventions including; a lecture on cytotoxic
preparation and practice simulation on the basic knowledge of and skills in the preparation of cytotoxic
drugs before, immediately after, and one month after the interventions. The study was designed as a one
group pre-/post-test type in which eight participants completed a pre-test of a measurement of basic
knowledge of cytotoxic drugs as well as an assessment of skills involved in cytotoxic preparations. This
assessment was developed based on a standard checklist of preparation skills from a range of different
guidelines and was subsequently implemented by a panel of assessors consisting of three clinical
pharmacists, 4 technicians, and 1 temporary staff working. The participants were then exposed to the
interventions containing of a lecture on cytotoxic preparation, practice simulation on the basic knowledge
of and skills in cytotoxic preparation, then the assessments were repeated. Results from these processes
were followed by immediate post-test. One month later, similar assessments of basic knowledge and skills
were also performed. Attitudes of the participants toward these processes were also evaluated. The results
were reported using descriptive & statistical analyses in term of mean ± SD, frequencies, paired t-tests,
and Wilcoxon. The results showed there was no significant differences between basic knowledge scores in
pre- compared to immediate post-tests, and in immediate compared to 1 month post-tests (p = 0.070
and 0.336 respectively). The overall results of the skills assessment in cytotoxic drugs preparation
demonstrated significant differences in scores including basic knowledge, cytotoxic drugs preparation skills
between the pre- and immediate post-tests, and between the scores in the immediate posttest and 1 Interventions on Basic Knowledge of and Skills of Health Care Workers in the Preparation of Cytotoxic Drugs month post-tests (p = 0.026 and 0.045 respectively). The immediate posttest scores were significantly
higher in all aspects preparation skills compared to those of pre-test (p = 0.001, 0.021, and 0.017
respectively). However, there were no significant differences between the immediate posttest and 1 month
post-test scores in the 3 skills including; aseptic hand-washing, vertical laminar air flow hood, and
hazardous drug vial preparation (p = 0.279, 0.593, and 0.086, respectively). Generally, the attitudes of
the participants to the implementation of the intervention were favorable. Conclusively, the intervention
improved basic knowledge of and skills in the preparation of cytotoxic drugs and participantsû attitudes to
the intervention were positively favorable.
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