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Introduction: Drug dosing errors are common in renally impaired patients. Appropriate dosage adjustment is important to ensure patient safety and to avoid adverse drug effects or poor outcomes. The objective of the present study was to assess the pattern and number of the inappropriate dosage adjustment in hospitalized patients with renal impairment to improve future renal dosage adjustment guidance. Methods: The prospective study was conducted in patients with renal impairment from August to October 2016 at Internal Medicine wards of the Sunprasittiprasong Hospital. Inappropriate dosage adjustment was reported by using descriptive statistics. Results: 1,235 patients were evaluated. The study found 180 patients (14.6%) had renal impairment. 21out of 180 patients (11.7%) with renal impairment received inappropriate dosage regimens. The study also found that 232 medications required dosage adjustment. 211 (90.9%) medications were renally adjusted appropriately while 21 (9.1%) were inappropriately adjusted. Of the 21 pharmacist recommendations, physicians accepted a total of 14 (66.7%). Conclusion: The study identified a number of renal impaired subjects who received inappropriate dosage regimens. The two most common drug classes that were not renally adjusted appropriately are antibiotics and cardiovascular drugs. Therefore, this renal dosage guidance may be useful to improve future renal dosage guidance to be used in other medical units.
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