Eutectic system as drug delivery for periodontitis treatment
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Abstract
Introduction: Eutectic system of menthol (M) and camphor (C) was suitable as solvent for local delivery system for periodontitis treatment because local anesthetic and antimicrobial activities. Ibuprofen is one of drugs of choice for periodontitis treatment as anti-inflammation and pain managements. The local administration of ibuprofen with prolong released property was developed. Methods: Ibuprofen was loaded into eutectic system of M:C as the delivery system for periodontitis treatment. Ibuprofen-loaded eutectic system was developed. Their physical properties and drug released profile were investigated. Results: The 5:5 M:C was selected as solvent in this study. The viscosity of ibuprofen-loaded eutectic (iES) was increased as concentration of ibuprofen increased and exhibited the Newtonian flow. Ibuprofen-loaded polymeric eutectic solution (PES) containing 10% ibuprofen and 30% Eudragit® E PO in eutectic solvent showed high viscosity apparently and exhibited Newtonian flow. The eutectic formation was confirmed with melting behavior study under hot stage microscope. Melting point of 5:5 M:C was lower than that of individual menthol and camphor. The highest solubility of ibuprofen was obtained in dimethyl sulfoxide; however, solubility of ibuprofen in eutectic solvent was markedly higher than those of water or phosphate buffer solution pH 6.2. The ibuprofen release could be sustainable from iES and PES. Conclusion: The developed eutectic drug delivery system of ibuprofen was potentially for periodontitis treatment which prolong released property and the eutectic solvent was local anesthetic and antimicrobials agent
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