A Feasibility Study of Alcoholic-Alkaline Treated Rice Starch as Filler in Tablet Dosage Forms for Health Product

Abstract

The objectives of this research were to study the physical properties of alcoholic-alkaline treated rice starch (MRS) using 40 %v/v and 50 %v/v of alcohol.  The properties of MRS as filler were compared with those of spray dried rice starch (SDRS) as a commercial product.  The properties of health product tablet using curcumin powder as an active ingredient were investigated.  The result showed that starch granule was not appeared.  Swelling of MRS was occurred.  The swelling capacity of MRS (40 %v/v) and MRS (50 %v/v) in distilled water, hydrochloric acid (0.1 M) and phosphate buffer (pH 6.8) were similar.  To compare MRS and SDRS as filler, the hardness of tablet using MRS (40 %v/v) was the lowest and the friability was the highest.  The hardness of tablet using MRS (50 %v/v) was higher than the tablet using SDRS.  The friability of tablet using MRS (50 %v/v) was lower than the tablet using SDRS.  The hardness of curcumin tablet using MRS (50 %v/v) or SDRS as a filler was about 6 kP and disintegration time was less than 10 minutes.  Friability of the tablet using MRS (50 %v/v) and SDRS were 0.46 % and 0.71 %, respectively.  It can be concluded that MRS (50 %v/v) can be used as filler in health product tablet.