A Systematic Review and Meta-analysis on Efficacy of Thunbergia laurifolia L. In Pesticide Intoxication In Blood stream
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Abstract
Introduction: Thunbergia laurifolia L. has a history in Thai traditional medicine for pesticide intoxication but there were no systematic review and meta analysis to assess its efficacy for pesticide intoxication in human study. Methods: MEDLINE, CINHAL, Cochrane Central of clinical trial, ThaiLis and handsearching were searched from the inception date of 31 October 2015 using scientific and common synonyms of T. laurifolia, pesticide or intoxication. The references lists of retrieved articles were also reviewed. Clinical controlled human intervention trials on T. laurifolia L. in any dosage forms without co-medication were included in this study. The methodological quality of studies was assessed using Cochrane’s risk of bias assessment and Jadad’s quality scales. Results: Seven studies met the inclusion criteria but only two trials performed Randomized controlled trial (RCT) with high quality. Meta-analysis shows T. laurifolia increase serum cholinesterase significantly (MD=-6.06; 95%CI=-11.73, -0.40; p=0.04). However, there was no significant in acetylcholinesterase level between T. laurifolia L and placebo (MD=0.03;95%CI=-0.09, 0.15; p=0.63). The placebo can increase number of participants to low risk and normal level than T. laurifolia L significantly (RR=2.49; 95%CI=1.19, 5.22; p=0.02). Conclusion: This systematic review and meta-analysis suggests that T. laurifolia has potential to improve serum cholinesterase but the large well designed RCT will provide definitive data on its efficacy.
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