Devlopment of Mushroom Tablets From Lentinus edodes, Pleurotus ostreatus and Pleurotus pulmonarius
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Abstract
Intro: Immune-modulating and anti-inflammatory compound such as beta-glucans is a natural compound found in several kinds of foods such as some mushrooms. The inflammation relates to the severity of gout symptom thus it is possible to use beta-glucan to relive the inflammation of gout disease. This study aims to develop the formulation of mushroom tablets for medical application. Methods: Pre-formulation of 3 types of mushroom powders (Lentinus edodes, Pleurotus ostreatus and Pleurotus pulmonarius) were performed and direct compression method with 500 mg per tablet at 60 MPa was used in this study. The effects of the additivesamount such as adsorbent (Aerosil®, silicon dioxide) and disintegrant (Avicel® PH102, microcrystalline cellulose PH102) at concentration 0.1-1 % and 3-4 %, respectively, on the characteristics of mushroom tablets were investigated. All experiments were evaluated for moisture content, flowability, compressibility, weight variation, friability, disintegration time, hardness and thickness following the quality control guideline of United State Pharmacopeia 36 (USP 36). Results: As the pre-formulation results, the moisture content of mushroom powders was less than 10 percent (%LOD<10%). The flowability of mushroom powders was poor since the angle of repose and compressibility index were in range of 36.82-48.59 degree and 21.69-34.29, respectively. Each mushroom powder without additives was able to form a tablet with a negative value of friability test and high disintegration time (greater than
30 min). Fortunately, the addition of 0.1% Aerosil® and 3.9% Avicel® PH102 was helpful for the characteristic of mixed mushroom tablets. Following the additives addition, the friability was low (0%) and disintegration time of tablets was less than 30 minutes. Conclusions: Conclusively, direct compression method is able to use for mixed mushroom tablets formulation. The additives such as of Aerosil® and Avicel® PH102 have been used as the adsorbent and disintegrant, respectively.
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