Increasing Drug Adherence by Using Multimedia and Pharmaceutical Care for Patients with Major Depressive Disorder
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Abstract
Introduction: This study aim to evaluate the effects of multimedia with pharmaceutical care to promote adherence for patients with depressive disorders. Method: The design of this study was a randomized controlled trial. Outpatients with major depressive disorder were recruited. Sixty-eight patients were randomized to the experimental group which were assigned to watch multimedia related cause of depressive disorder, principle of treatment, adverse drug reaction management combine with pharmaceutical care (33 cases) and the control group which were received usual care (35 cases). Result: The participants of the study were not significantly different in characteristics except alcohol consumption is greater number in experimental than control group while exercise in experimental group is less than control group. However, these two factors are not effect to adherence. Baseline of adherence, drugs related problems (adverse drug reaction and drug interaction), knowledge and understanding of disease and medication were not different between experimental and control group. After 1 month of the study, the results showed that the experimental group (0.9 ± 1.40 points) had scores on adherence significantly better than control group (2.2 ± 1.71 points) (p <0.001). Adverse drug reactions happened in experimental group (7 patients, 21.2 percent) significantly less than control group (17 patients, 48.6 percent) (p = 0.023). Drug interaction appeared non-different between two group (p=0.230). Knowledge scores in experimental group (9.2±2.18 points) significantly more than control group (7.7±2.30 points) (p=0.007). Patients in experimental group had 9Q scores reduce from 4.2±7.26 to 1.7±4.21points. The multimedia satisfaction score was 89.1%. Conclusion: Using multimedia with pharmaceutical care is effective choice to promote adherence and solve drug related problems.
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