Computer Program for Designing Appropriate Dosage Regimen of Vancomycin in Post Operative Congenital Heart Disease Pediatric Patients

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Wanapa Hinwiset
Yupaporn Preechagoon
Seehapong Petcharat


Introduction: The problem when using vancomycin is large inter-patient and narrow therapeutic range and it has various side effects such as nephrotoxicity, ototoxicity and Red-man syndrome. Therefore, appropriate dosage regimen for individualized patient provided the most effective and less toxicity for pediatric patients. The objective of this study was to develop computer program for calculation of pharmacokinetic parameters, dosage regimen, and predicted concentrations of vancomycin in pediatric patients. Materials and Method: The program was developed from the data of 99 post operative congenital heart disease pediatric patients using Microsoft visual studio .NET 2008 and writing with C# language and the program was validated in comparison with previous study using root mean square error (RMSE) for analyzing precision. Results: For program validation, the data of 13 pediatric patients were used to calculate pharmacokinetic parameters and concentrations. RMSE of peak and trough concentrations were 3.21 mg/L and 5.59 mg/L, respectively. The error from this study was lower than previous study by Marqués-Miñana MR et al. with the RMSE of peak and trough concentrations were 7.17 mg/L and 6.68 mg/L, respectively. Conclusion: Computer program of vancomycin was successfully developed for designing appropriate dosage regimen. In addition, the use of this program easier and faster calculation than manual method. Moreover, it is very useful for pharmacist and healthcare teams in management vancomycin therapy in such patients.


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Pharmaceutical Practice


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