Ertapenam Use Pattern and Utilization Volume and Susceptibility Rate of E. coli ESBL and K. pneumoniae ESBL to Ertapenem in Mahasarakham Hospital

Abstract

Introduction:  In 2014, Ertapenem expenditure was the second of in-patient drug expenditure in Mahasarakham hospital. This study aimed to determine Ertapenem use pattern and utilization volume and drug sensitivity in Mahasarakham hospital. Methods: A retrospective study was conducted from Mahasarakham hospital database. Ertapenem use pattern was reviewed from 6-month medication records during October 2013-March 2014. Utilization volume and drug sensitivity were retrieved from 4-year data during 2011-2014. Results: Of 185 patients receiving Ertapenem in 6 months, most of them were male (58.4%), aged 60+15.5 years and admitted in surgical department (81.1%). For pattern of use, 81.6% were empirical therapy and 18.4% were specific therapy, which were used for E. coli ESBL treatment (11.9%). Ertapenem use was increased from 10.90 DDD/1,000 patient-days in 2011 to 18.76 DDD/1,000 patient-days in 2014. During the 4-year period, susceptibility rates of Ertapenem for E. coli ESBL and K. pneumoniae ESBL were declined. Conclusion: Ertapenem use in Mahasarakham hospital is increasing and mostly empiric therapy. The hospital should enact a policy to control Ertapenem use and promote rational drug use.