Discontinuation rate of hormonal therapy in early stage breast cancer patients

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Suwatinee Intree
Arom Jedsadayanmata


Introduction: Five years of adjuvant hormonal therapy for estrogen receptor (ER)-positive breast cancer appears to improve survival in women with breast cancer. However, information on hormonal therapy discontinuation is scanty. The objective of this study was to investigate the discontinuation rate of hormonal therapy in early stage breast cancer patients in Thailand. Materials and Method: In this retrospective cohort study, data on medication therapy of patients diagnosed with early stage breast cancer (stage I-III) prescribed hormonal therapy at oncology center in Thailand between January 2004 and December 2009 were retrieved from medical records for review. Results: A total of 385 patients were recruited. Overall, 52 (13.5%) patients discontinued hormonal therapy before the completion of 5 years. Discontinuation rate was 52/1,405 person-years or 3.7/100 person-years of follow-up. The cumulative incidence of hormonal therapy discontinuation at 1, 2, 3, 4 and 5 years was 5.7%, 8.8%, 10.6%, 11.9% and 13.5%, respectively. Conclusion: Discontinuation rate of hormonal therapy in early stage breast cancer patients was 3.7/100 person-years and the highest rate was in the first year of treatment


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Pharmaceutical Practice


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