Time to progression of end-stage renal disease in type 2 diabetic patients : a retrospective study from electronic database

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Santhad Sriphonthong
Parimoke Kerdchantuk
Surasak Chaiyasong

Abstract

Introduction: There has been an increasing of end-stage renal disease in patients with type 2 diabetes. The K/DOQI 2002 guideline showed the year until kidney failure based on level of GFR and rate of GFR decline. Objective: The study was aimed to show the table of time in progression of end-stage renal disease in type 2 diabetic patients. Materials and Methods: The data was retrospectively collected from the hospital retrospective electronic database between January, 2003 to December, 2012 in patients with type 2 diabetes. The result revealed at least two separated value of serum creatinine for at least 12 month period to calculate the estimated GFR by the CKD-EPI equation, Therefore, the first value of GFRs which was less than 15 ml/min/1.73m2 and the second value was gone back and calculated the time as year of end-stage renal disease back to the second GFR and calculate the declined GFR per year. Results: Total of 31,457 type 2 diabetic patients were recruited while 635 patients were reported with ESRD. Most of them were female (64.57%). At the time of first GFR found, the mean GFR was 10.50 ml/min/1.73m2. At the time of second GFR found, the mean age was 61.15 years old, mean GFR was 35.08 ml/min/1.73m2. The mean rate of decline in GFR was 7.59 ml/min/1.73m2/year within mean 3.24 years. Conclusion: The patients with type 2 diabetes older than 60 years old, the mean rate of decline in GFR was 7.59 ml/min/1.73m2/year, so fast. Therefore, prevention of kidney as fast until diagnosis of type 2 diabetes is the best way.

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Pharmaceutical Practice

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