Albumin Usage Review for Appropriate Drug Evaluation and Value at Queen Sirikit Heart Center of the Northeast, Thailand
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Abstract
Albumin is the most abundant circulatory protein. It exerts colloid oncotic pressure and transports various substances. Previous studies revealed that over 50% of albumin usage was unappropriated and higher costs, this study aimed to investigate the prescription patterns and value of albumin at the Queen Sirikit Heart Center of the Northeast, Khon Kaen University to assess the appropriateness and value of prescription. Methodology: This retrospective study involved data collect from patients whom received albumin at the Queen Sirikit Heart Center of the Northeast, Khon Kaen University, used Queen Sirikit Heart Center criteria, between October 1, 2021, and March 31, 2022. Results: Patients received albumin in 104 cases in 631 prescriptions. Pediatric patients received albumin in 84 prescriptions, 73.81% of whom were male, aged three days to 17 years (61.48±13.68 years). The majority received treatment at the pediatric intensive care unit, accounting for 55.95%. Adult patients received albumin in 547 prescriptions, 63.07% of whom were male, aged 19 to 95 years (5.08±5.32 years). The majority received treatment at the cardiac surgery intensive care unit, accounting for 32.48 %. The primary indication was priming solution for open heart procedures, representing 57.14% in pediatric patients and 63.07% in adult patients and all of them were appropriated. Albumin prescriptions met the treatment criteria 95.24% in pediatric patients and 93.78% in adult patients. The total value for appropriated albumin prescriptions was 145,873 baht in pediatric patients and 808,961 baht in adult patients, with the expenditure on albumin per prescription was 1,808 baht in pediatric patients and 1,567 baht in adult patients. Conclusions: Over 90% of the patients who received albumin were prescribed appropriately and value was more than 1,500 baht per prescription.
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