Fruits Anti-Cancer Drugs Interaction Treatment

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Surachet Lamkam
Trai Tarnpanich


Fruits are one kind of food which has been widely consumed. However, some fruits have reported altering the Cytochrome P450 enzyme and P-glycoprotein (P-gp). Fruit-drug interaction can occur when taken together. The list of fruits that have been reported to change the action of the enzymes and P-gp includes Grapefruit, Star fruit, Pineapple, and Pomelo. Thus, it might change cancer drug levels, affecting efficacy and adverse effect of treatment. Most data of fruit-drug interaction come from in vivo studies. Data of human clinical study is limited. However, the available data can be applied to monitoring adverse drug reactions of anti-cancer medications, pharmaceutical care in cancer patients, and providing information about consuming fruits safely in patients undergoing systemic medicines for cancers.


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