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At present, LINE application is widely used. Several previous studies have used applications for interventions in patients with diabetes. However, no studies have been conducted using the LINE application for intervention in diabetic patients instead of healthcare providers at hospitals, like a pharmacist. No additional information was given to patients at the hospital. Objective: to examine the effects of LINE application-based pharmacist intervention on clinical outcomes, diabetes knowledge, and medication adherence in patients with diabetes. Methods: The study was a randomized controlled trial. Samples were patients who received treatment in an outpatient diabetes clinic of a community hospital in Nakhon Si Thammarat Province. A total of 180 recruited patients were randomly allocated to one of two groups: the study group (n = 90) and the control group (n = 90). The study group received diabetes education via LINE application of mobile phone once a week for six months. No additional patient education was provided at the hospital. A patient could contact the pharmacist through the application if needed. The control group received usual care. Diabetic self-care guides were distributed to both groups. Results: The study group had significantly lower glycosylated hemoglobin (HbA1c) and fasting plasma glucose (FPG) levels than the control group at the end of the trial (HbA1c = 7.59 + 1.21% and 8.20 + 1.42%, respectively; P = 0.003 and FPG = 141.02 + 25.13 mg/dL and 163.27 + 47.32 mg/dL, respectively; P < 0.001). Lipid levels and blood pressure of the study group were not substantially different from those of the control group (P > 0.05). Diabetes knowledge and medication adherence scores in the study group were significantly greater than those in the control group (P < 0.001 and P = 0.003, respectively). Conclusion: The intervention by pharmacists through LINE application allows adults living with diabetes to control their sugar levels better, having increased knowledge about diabetes and medication adherence.
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