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Introduction: Curcuma comosa composed of phytoestrogenic compounds that have been reported to have several bioactivities. However, the scientific support the use of Curcuma comosa in dermal applications are still limited. The purposes of this research were to investigate the potential of skin bioactivities of C. comosa and develop nanostructure lipid carrier system for transcutaneous delivery. Methods: Curcuma comosa was extracted in n-hexane. Skin bioactivities of the extract were investigated include antioxidation, tyrosinase inhibitor and in vitro collagenase inhibition. Nanostructure lipid carrier systems were developed. Effect of solid lipid, oil as well as chemical skin permeation enhancers on particle characterization, % encapsulation efficiency, thermal property of lipid, in vitro skin permeation ability by Franz diffusion cells and stability of the formulations were evaluated. Results: The obtained C. comosa extract from hexane have concentrated semisolid characteristic rich in phytoestrogen. Skin bioactivities compared with the controls were mild activities. The developed NLC systems had the particle size in the range of 120 – 170 nm, PDI 0.25 - 0.29, approximate zetapotential was -20 mV, higher %EE than 90, good physical stable when kept at 25 and 40 ˚C for 90 days. After 24 hours, chemical enhancers facilitated 3.2 to 5.3% of the active DA2 through the stratum corneum. The lipophilic property of C. comosa extract limited DA2 skin permeation and the active was mostly accumulated within the epidermis skin layer. Conclusion: Curcuma comosa extract loaded NLC has a potential to be further developed as transdermal delivery of phytoestrogenic compound for local action of hormone replacement therapy with low systemic side effect.
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