Monitoring the achieving therapeutic target in warfarin-administered patients by International normalized ratio at Prasat Neurological Institute
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Abstract
Warfarin is the drug that can monitor its effi cacy and safety of treatment by the usage of International normalized ratio (INR) value. The objective of this study is to determine the percentage of achieving therapeutic target INR in warfarin-administered patients at Prasat Neurological Institute. Methods: This study was retrospective-descriptive study design and data were collected from medical records of the patients receiving warfarin in outpatient department at Prasat neurological institute for 3 years (July 2009 - July 2012). Results: Three hundred eigthty nine patients were included into the study, average age was 63.04 years old. Most patients receiving warfarin for preventing embolism in patients with atrial fi brillation (36.76%). The average duration of INR monitoring was 1.05 years and the frequency of INR monitoring was 10.12 times per year. The percentage of achieving therapeutic target INR was only 37.28%. This study found that 47.08% was below and 15.64% was exceed the therapeutic target INR. Proportion of low variability of INR values was 8.74%. The most prescribed medications that had were potential drug interactions with warfarin was anti-dyslipidemia medications. Twenty-six events of warfarin adverse drug reactions were found including: 1.95 time/100 person-year of major bleeding and 4.39 time/100 person-year of minor bleeding. Conclusion: The results of this study can be used as a base line to organize the warfarin clinic at Prasat Neurological Institute.
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