Formulation and characterization of cream containing Yang-na oleoresin-loaded in polymeric nanoparticles
Article Sidebar
Main Article Content
Abstract
Introduction: The aims of this study were to formulate and characterize formulations consisting Yang-na oleoresin-loaded in polymeric nanoparticles. Yang-na oleoresin consisted of essential oil and phenolic compounds which are sensitive to light, air and oxygen. To overcome this obstacle, Yang-na oleoresin was prepared by loading in polymeric nanoparticles before incorporate into creams. Materials and methods: Firstly, physicochemical properties of Yang-na oleoresin, for instance, miscibility, total phenolic compounds (TPC) and antioxidant activities were investigated. Secondly, Yang-na oleoresin was loaded in polymeric nanoparticles using chitosan and gellan gum by complex-coacervation method. The chitosan-gellan gum (CS-GG) nanoparticles-loaded Yang-na oleoresin were characterized in terms of zeta potential, particle size and %entrapment efficiency. The suitable formulation was selected to incorporate into oil in water (o/w) cream base. Lastly, physicochemical characteristics of creams including appearance, odor, pH-value, viscosity, phase separation and amount of TPC were investigated both before and after accelerated stability. The accelerated stability was conducted by heating/cooling for 6 cycles. Results: Results of miscibility study revealed that Yang-na oleoresin was well dissolved in absolute ethanol and dimethyl sulfoxide in the ratio of 1:50. The amount of TPC of 2% (v/v) of Yang-na oleoresin in absolute ethanol was 1.683 ± 0.057 mgGAE/ml. The 50%inhibitory concentration of Yang-na oleoresin was 0.931 mg/ml determined by DPPH assay whereas the %lipid peroxidation of Yang-na oleoresin was 83.51%. The particle size, zeta potential and %entrapment efficiency of optimized CS-GG nanoparticles-loaded with Yang-na oleoresin were 128 nm, 14 mV and 27.82%, respectively. After accelerated stability, cream base, control cream and Yang-na cream preparing from the suitable formulation which consisted of glycerol monostearate had smooth texture and showed the highest stability. The pH-value and the viscosity of these formulations were 4.6-5.4 and 22.745 ± 463-29,337 ± 522 cP, respectively. The amounts of TPC containing in the Yang-na cream and control cream were found to be 93.6 and 80.1%, respectively. The amount of TPC in Yang-na cream was significantly higher than the control cream (p=0.036). Conclusion: It was concluded that the formulation of cream containing Yang-na oleoresin-loaded in polymeric nanoparticles had the highest stability compared to other formulations and it was suitable for human skin. Furthermore, the polymeric nanoparticle system was proven to be able to protect the active compounds against oxidation process.
Article Details
In the case that some parts are used by others The author must Confirm that obtaining permission to use some of the original authors. And must attach evidence That the permission has been included
References
Amorati, R., Foti, M. C., & Valgimigli, L. (2013). Antioxidant activity of essential oils. Journal of Agricultural and Food Chemistry, 61(46), 10835–10847.
Arthur H, Kibbe. (2000). Handbook of PHARMACEUTICAL EXCIPIENTS. Printed in the United States of America.
Aslam, M. S., Ahmad, M. S., & Mamat, A. S. (2015). A phytochemical, ethnomedicinal and pharmacological review of genus dipterocarpus. International Journal of Pharmacy and Pharmaceutical Sciences, 7(4), 27-38.
Ayala, A., Muñoz, M. F., & Argüelles, S. (2014). Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxidative Medicine and Cellular Longevity, 2014.
Badmus, J. A., Adedosu, T. O., Fatoki, J. O., Adegbite, V. A., Adaramoye, O. A., & Odunola, O. A. (2011). Lipid peroxidation inhibition and antiradical activities of some leaf fractions of Mangifera indica., Acta Poloniae Pharmaceutica, 68(1), 23-29.
Balasundram, N., Sundram, K., & Samman, S. (2006). Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses. Food Chemistry, 99 (1), 191-203.
Brewer, M. S. (2011). Natural antioxidants: sources, compounds, mechanisms of action, and potential applications. Comprehensive Reviews in Food Science and Food Safety, 10(4), 221-247.
Burger, P., Charrié-Duhaut, A., Connan, J., Flecker, M., & Albrecht, P. (2009). Archaeological resinous samples from Asian wrecks: Taxonomic characterization by GC-MS. Analytica Chimica Acta, 648(1), 85-97.
Dai, J., & Mumper, R. J. (2010). Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules, 15(10), 7313-7352.
Daudt, R. M., Back, P. I., Cardozo, N. S. M., Marczak, L. D. F., & Külkamp-Guerreiro, I. C. (2015). Pinhão starch and coat extract as new natural cosmetic ingredients: Topical formulation stability and sensory analysis. Carbohydrate Polymers, 134, 573-580.
Dzialo, M., Mierziak, J., Korzun, U., Preisner, M., Szopa, J., & Kulma, A. (2016). The potential of plant phenolics in prevention and therapy of skin disorders. International Journal of Molecular Sciences, 17(2), 160.
Garbossa, W. A. C., & Campos, P. M. B. G. M. (2016). Euterpe oleracea, Matricaria chamomilla, and Camellia sinensis as promising ingredients for development of skin care formulations. Industrial Crops and Products, 83, 1-10.
Guterres, S. S., Alves, M. P., & Pohlmann, A. R. (2007). Polymeric nanoparticles, nanospheres and nanocapsules, for cutaneous applications. Drug Target Insights, 2, 147.
Hakim, E. H., Juliawaty, L. D., Syah, Y. M., Achmad, S. A., Latip, J., & Ghisalberti, E. L. (2006). Cytotoxic resveratrol oligomers from the tree bark of Dipterocarpus hasseltii. Fitoterapia, 77(7), 550-555.
Hosseini, S. F., Zandi, M., Rezaei, M., & Farahmandghavi, F. (2013). Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: preparation, characterization and in vitro release study. Carbohydrate Polymers, 95(1), 50-56.
Katalinić, V., Možina, S. S., Skroza, D., Generalić, I., Abramovič, H., Miloš, M., Terpinc, P. (2010). Polyphenolic profile, antioxidant properties and antimicrobial activity of grape skin extracts of 14 Vitis vinifera varieties grown in Dalmatia (Croatia). Food Chemistry, 119(2), 715-723.
Kligman, A. M. (1965). Topical pharmacology and toxicology of dimethyl sulfoxide-Part 1. Jama, 193(10), 796-804.
Lathsamee, T., Khunkitti, W., & Sakloetsakun, D. (2017). Preparation of Yang-na oleoresin-loaded polymeric nanoparticles by layer-by-layer method. NGRC 44. Proceeding to The 44th National Graduated Research Conference, October 19-20, 2017. Ubon Ratchathani University. (P.657-666)
Li, H.-J., Zhang, A.-Q., Hu, Y., Sui, L., Qian, D.-J., & Chen, M. (2012). Large-scale synthesis and self-organization of silver nanoparticles with Tween 80 as a reductant and stabilizer. Nanoscale Research Letters, 7(1), 612.
Lúcio, M., Nunes, C., Gaspar, D., Ferreira, H., Lima, J. L., & Reis, S. (2009). Antioxidant activity of vitamin E and Trolox: understanding of the factors that govern lipid peroxidation studies in vitro. Food Biophysics, 4(4), 312-320.
Mansouri, A., Embarek, G., Kokkalou, E., & Kefalas, P. (2005). Phenolic profile and antioxidant activity of the Algerian ripe date palm fruit (Phoenix dactylifera). Food Chemistry, 89(3), 411-420.
Nipaporn, N., Somporn, K., & Nattida, W. (2014). The study of antioxidant capacity of ethanolic extracts from Yang-na tree (Dipterocarpus alatus Roxb. Ex G. Don). Proceeding of The 2nd NEU National and International Research Conference 24 May 20014.
Osmalek, T., Froelich, A., & Tasarek, S. (2014). Application of gellan gum in pharmacy and medicine. International Journal of Pharmaceutics, 466(1), 328-340.
Rangari, A. T., & Ravikumar, P. (2015). Polymeric Nanoparticles Based Topical Drug Delivery: An Overview. Asian Journal of Biomedical and Pharmaceutical Sciences, 5(47), 5.
Ribeiro, R. C. de A., Barreto, S. M. A. G., Ostrosky, E. A., Rocha-Filho, P. A. da, Veríssimo, L. M., & Ferrari, M. (2015). Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent. Molecules, 20(2), 2492-2509.
Roberto, G., & Baratta, M. T. (2000). Antioxidant activity of selected essential oil components in two lipid model systems. Food Chemistry, 69(2), 167-174.
Ruttanamongkol. N., Katekaew, S., & Lekphrom (2014). Thesis title: Purification and Characterization of major compounds in oil of Dipterocarpus alatus Roxb. Ex G.Don. Faculty of Science, Khon Kaen University
Scalia, S., Trotta, V., Iannuccelli, V., & Bianchi, A. (2015). Enhancement of in vivo human skin penetration of resveratrol by chitosan-coated lipid microparticles. Colloids and Surfaces B: Biointerfaces, 135, 42-49.
Singh, M., Sharma, S., Khokra, S. L., Sahu, R. K., & Jangde, R. (2011). Preparation and evaluation of herbal cosmetic cream. Pharmacologyonline, 2, 1258-1264.
Sun, C., Wu, Z., Wang, Z., & Zhang, H. (2015). Effect of ethanol/water solvents on phenolic profiles and antioxidant properties of Beijing propolis extracts. Evidence-Based Complementary and Alternative Medicine, 2015.
Waqas, M. K., Akhtar, N., Ahmad, M., Murtaza, G., Khan, H. M., Iqbal, M., Bhatti, N. S. (2010). Formulation and characterization of a cream containing extract of fenugreek seeds. Acta Poloniae Pharmaceutica, 67(2), 173-178.
Wu, L., Zhang, J., & Watanabe, W. (2011). Physical and chemical stability of drug nanoparticles. Advanced Drug Delivery Reviews, 63(6), 456–469.
Zain, W., Ahmat, N., Norizan, N. H., & Nazri, N. (2011). The evaluation of antioxidant, antibacterial and structural identification activity of trimer resveratrol from Malaysia’s Dipterocarpaceae. Australian Journal of Basic Applied Sciences, 5(5), 926-929.
Zhao, Y., Wang, C., Chow, A. H., Ren, K., Gong, T., Zhang, Z., & Zheng, Y. (2010). Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: formulation and bioavailability studies. International Journal of Pharmaceutics, 383(1), 170-177.