The Analysis of Modified-Release Drug Trade Names Which are Available in Thailand
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Abstract
Trade names of pharmaceutical products are used to signify the difference in active ingredients, strengths and drug release characteristics. Modified-release drugs (MRDs) often contain a suffix in the trade name to convey a releasing pattern that differs from the profile of immediate-release drugs or to specify a certain type of modified-release. Common suffixes are words that clearly convey each releasing pattern. The use of uncommon suffixes may cause medication errors. The objectives of this research are to compile a list of trade names of MRDs which are available in Thailand and to analyze if their suffixes agree with the release characteristic of the product. This research aims to raise awareness of various types of modified-release characteristics among health care professionals in order to limit medication errors. Methods: Collect trade names of oral MRDs which are available in Thailand form four public databases: TMT, Monopoly, MIMS Thailand and Orange book. Organize trade names by the patterns of modified-release. Analyze the nomenclature of drug trade names and compare the meaning of their suffixes with the release characteristic of the product. Summarize the features of MRD trade names that are sold in Thailand and their availability in the National List of Essential Medicine (NLEM). Results: Oral MRDs that are sold in Thailand comprise of 1,053 trade names, 609 items (58 %) are in the NLEM. Most therapeutic categories of NLEM include MRDs, but MRDs are most used in the treatment of central nervous system disorders. In general, the trade names of MRDs that are available in Thailand often fail to provide appropriate clues for drug releasing profiles. Among 1,053 trade names, only 32% contain suffixes (23% with common suffixes and 9% with uncommon suffixes) and 68% do not use any suffixes. Conclusion: Most MRDs use trade names that do not contain any suffixes or use some that lack of standard. This naming practice may create confusion among healthcare providers and potentially develop into medication error events. The compiled list of MRDs is available at https://gg.gg/mrd-thailand.
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References
American Medical Association. United States adopted names naming guidelines [Online]. [cited 2018 Jan 2]. Available from: https://www.ama-assn.org/united-states-adopted-names-naming-guidelines.
Audit Center, Department of Social Development and Welfare, Ministry of Social Development and Human Security. Government Procurement and Supplies Management Act B.E. 2560 [Online]. 2016 Feb 24 [cited 2018 Jan 4]. Available from: http://61.19.50.59/audit/Centers/View.aspx?id=112&type=1.
Aulton ME, Taylor KMG. Modified-release oral drug delivery. In: Aulton ME, Taylor KMG, editors. The design and manufacture of medicines. 4th ed. Edinburgh: Churchill Livingstone/Elsevier; 2013. 550-65.
Bureau of Information. Office of the Permanent Secretary. Ministry of Public Health. Deputy Minister of Public Health reveals health safety strategies for patients and healt care personnels in Thailand [Online]. 2017 Sep 19 [cited 2018 Apr 20]. Available from: https://pr.moph.go.th/iprg/include/admin_hotnew/show_hotnew.php?idHot_new=100626.
Chumchit C, Amrumpai Y. Medication management system for medication safety in hospital: an analysis on problems and opportunity for improvement. Thai Pharm Health Sci J 2009; 4(1): 127-35.
CMP Medica. Drug information [Online]. 2017 Sep 14 [cited 2017 Mar]. Available from: https://www.mims.com/.
Ding H. Modified-release drug products and drug devices. 2016. In: Applied biopharmaceutics & pharmacokinetics [Internet]. New York, NY: McGraw-Hill. 7th. [cited 2017 Dec 27]. Available from: accesspharmacy.mhmedical.com/ content.aspx?aid=1117901135.
Drug Watch Center. Why should drug pricing and patent status information be required during the application for registration of drugs? [Online]. 2015 Mar 17 [cited 2018 Jan 4]. Available from: http://www.thaidrugwatch.org/blog/?p=855.
Food and Drug Administration. Summary of monopoly drugs B.E. 2557 [Online]. 2014 Apr 29 [cited 2017 Aug 23]. Available from: http://www.fda.moph.go.th/sites/Drug/SitePages/SummarizeDrug.aspx.
Hicks RW, Becker SC, Cousins DD. MEDMARX data report. A report on the relationship of drug names and medication errors in response to the Institute of Medicine’s call for action. Rockville, MD: Center for the Advancement of Patient Safety, US Pharmacopeia; 2008.
Holquist C. FDA safety page: delayed-release vs. extended-release Rxs [Online]. 2007 Jul 23 [cited 2017 May 11]. Available from: http://drugtopics.modernmedicine.com/drug-topics/news/clinical/pharmacy/fda-safety-page-delayed-release-vs-extended-release-rxs?page=full.
Jr Allen LV, Popovich NG, Ansel HC. Solid oral modified-release dosage forms and drug delivery systems. In: Jr Allen LV, Popovich NG, Ansel HC, editors. Ansel's pharmaceutical dosage forms and drug delivery 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005. 260-75.
Lesar TS. Prescribing errors involving medication dosage forms. J Gen Intern Med 2002; 17(8): 579-87.
National Drug Development Commitee. National List of Essential Medicine B.E. 2559 [Online]. 2016 Oct 4 [cited 2017 Mar 13]. Available from: http://drug.fda.moph.go.th:81/nlem.in.th/medicine.
Office of the Council of State. Medicine Act B.E. 2510 [Online]. [cited 2018 Jan 2]. Available from: http://www.fda.moph.go.th/sites/Drug/LawDrug/%E0%B8%A204-20-9999-update.pdf.
Pennsylvania Patient Safety Authority. Drug name suffix confusion is a common source of errors. PA PSRS Patient Saf Advis 2004; 1: 17-8.
Ratanadejasakul C, Ratanadejasakul P. Medication error and its applications in drug management system [Online]. 2017 Jul 4 [cited 2018 Apr 18]. Available from: http://ccpe.pharmacycouncil.org/index.php?option=article_detail&subpage=article_detail&id=303.
Reed RC, Meinhold J, Dutta S, Liu W, Qiu Y. What do the suffixes – XR, ER, Chrono, Chronosphere – really mean as it pertains to modified-release antiepileptic drugs? J Clin Pharm Ther 2010; 35(4): 373-83.
Sarisut N. Formulation of extended-release drugs and drug deliver systems. Bangkok: Thaimit Printing; 1992. 293 p.
Sinchaipanid N. Multi-unit extended-release oral pharmaceutical products. Bangkok: Threelada; 2005. 128 p.
Thai Health Information Standards Development Center. Thai medicine terminology [Online]. 2017 Oct 2 [cited 2017 Oct 10]. Available from: http://www.this.or.th/tmt_download.php.
Thai Health Information Standards Development Center. TMT release [Online]. 2017 Oct 2 [cited 2017 Oct 10]. Available from: http://www.this.or.th/tmt_download.php.
The National Coordinating Council for Medication Error Reporting and Prevention. Promoting the safe use of suffixes in prescription drug names [Online]. 2007 Dec 3 [cited 2017 Oct 22]. Available from: http://www.nccmerp.org/promoting-safe-use-suffixes-prescription-drug-names.
The Stationery Office on Behalf of the Medicines and Healthcare Products Regulatory Agency. General monographs. In: British Pharmacopoeia Commission, editor. British pharmacopoeia. 3. London: Stationery Office; 2017. 39-76.
U.S. Food and Drug Administration. Guidance for industry: best practices in developing proprietary names for drugs [Online]. 2014 May [cited 2017 Oct 22]. Available from: https://www.fda.gov/downloads/drugs/guidances/ucm398997.pdf.
U.S. Food and Drug Administration. Orange Book data files [Online]. 2017 Aug. Available from: https://www.fda.gov/Drugs/InformationOnDrugs/ucm129689.htm.
U.S. Pharmacopeial Convention. Pharmaceutical dosage form/general information. In: U.S. Pharmacopeial convention, editor. US Pharmacopoeia-National Formulary [USP 39 NF 34]. 1. Rockville, MD: United States Pharmacopeial Convention, Inc.; 2016. 1448-68.