HETEROLOGOUS PRIME-BOOST COVID 19 VACCINE IN ADULT
Keywords:
heterologous prime – boosting, COVID-19 vaccinesAbstract
Since the SARS-CoV-2 (Severe Acute Respiratory Syndrome or Covid-19) pandemic outbreak in March 2020, there have been many studies on preventive measures against COVID-19 infection. There are personal measures such as frequent hand washing, wearing a face mask, keeping a distance from other people at least 1 meter, and public health measures such as closing large public places where a lot of people gather and contact tracing. However, giving people a vaccine against COVID-19 is the most effective way to reduce the spreading, severity, and mortality rate of COVID-19. The vaccination of COVID-19 has many obstacles, including inefficient vaccine distribution, SARS-CoV-2mutation, and serious side effects of vaccination. These difficulties make it impossible to use heterologous prime-boosting. Nowadays, there is a potential to use a vaccine combination (heterologous prime-boosting), which studies in both laboratory animals and humans found to be able to increase humoral immune response and possibly also raise cellular immune response. On the other hand, combined vaccination was found to have more adverse effects than complete vaccination and there is still a lack of long-term safety of heterologous vaccination, including surveillance for rare adverse events.
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