Canine perivascular wall tumors with bone metastasis of the proximal humerus in a Golden Retriever dog

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Phanthit Kamlangchai
Arayaporn Macotpet
Anudep Rungsipipat
Karn Yongvanit
Supranee Jitpean

Abstract

A 10-year-old male Golden Retriever dog presented with a two-week history of right forelimb lameness and shoulder pain. Initial examination revealed knuckling and muscle atrophy. Radiography and computed tomography scan results revealed severe osteolysis at the proximal humerus. Forequarter amputation was performed, and a bone biopsy confirmed a perivascular wall tumor with bony metastasis. Adjuvant metronomic chemotherapy was administered. Two months postoperatively, diffuse pulmonary nodules and visceral masses were detected, with no local recurrence. Despite palliative care, the dog succumbed to the disease 169 days after the initial diagnosis. This case underscores the aggressive nature of perivascular wall tumors and the challenges in managing advanced metastatic disease. Early detection and aggressive therapy are crucial for better outcomes in similar cases in veterinary practice.

Article Details

Section
Case reports

References

Avallone G, Boracchi P, Stefanello D, Ferrari R, Rebughini A, Roccabianca P, 2014. Canine perivascular wall tumors: high prognostic impact of site, depth, and completeness of margins. Vet Pathol 51, 713–721.

Avallone G, Helmbold P, Caniatti M, Stefanello D, Nayak RC, Roccabianca P, 2007. The spectrum of canine cutaneous perivascular wall tumors: morphologic, phenotypic and clinical characterization. Vet Pathol 44, 607–620.

Carpenter JL, Hamilton TA, 1995. Angioleiomyoma of the nasopharynx in a dog. Vet Pathol 32, 721–723.

Chiti LE, Ferrari R, Roccabianca P, Boracchi P, Godizzi F, Busca GA, Stefanello D, 2021. Surgical margins in canine cutaneous soft-tissue sarcomas: a dichotomous classification system does not accurately predict the risk of local recurrence. Animals 11, 2367.

Cho HS, Park NY, 2006. Primary haemangiopericytoma in the pelvic cavity of a dog. J Vet Med A Physiol Pathol Clin Med 53, 198–201.

Cohn-Urbach M, Chen A, Haldorson G, Thomovsky S, 2015. Perivascular wall tumor in the brain of a dog. Case Rep Vet Med 2015, 1-6.

Godizzi F, Avallone G, Ghisleni G, Dell’Aere S, Zamboni C, Valenti P, Roccabianca P, 2023. Primary intranasal perivascular wall tumors in 2 cats. J Vet Diagn Invest 35, 81–86.

Katsuta O, Doi T, Yokoyama M, Okazaki Y, Tsuchitani M, Kidachi F, 1998. Vascular leiomyoma of the mesentery in a dog. J Comp Pathol 118, 155–161.

Kim SJ, Yang DS, Han JH, 2012. Primary splenic hemangiopericytoma in a dachshund dog. Korean J. Vet Serv 35, 153–157.

Kluthcovsky LC, Queiroz TNL, Somensi M, Castro JLC, Engracia Filho JR, 2021. Angiofibroma of the nasal cavity in a dog: case report. Top Companion Anim Med 44, 100530.

Kravitz A, Davis G, Bastian RP, Fittipaldi K, 2019. Outcome and prognostic indicators for hemangiopericytomas in dogs: 167 cases (2009–2016). J Am Anim Hosp Assoc 55, 194–200.

Lana S, U’ren L, Plaza S, Elmslie R, Gustafson D, Morley P, Dow S, 2007. Continuous low‐dose oral chemotherapy for adjuvant therapy of splenic hemangiosarcoma in dogs. J Vet Intern Med 21, 764–769.

Leach TN, Childress MO, Greene SN, Mohamed AS, Moore GE, Schrempp DR, Lahrman SR, Knapp DW, 2012. Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer. Vet Comp Oncol 10, 102–112.

Loures FH, Conceição, LG, Lauffer-Amorim R, Nobrega J, Costa E, Torres R, Clemente JT, Vilória MI, Silva JCP, 2019. Histopathology and immunohistochemistry of peripheral neural sheath tumor and perivascular wall tumor in dog. Arq Bras Med Vet Zootec 71, 1100–1106.

Palmieri C, Avallone G, Cimini M, Roccabianca P, Stefanello D, Salda L, 2013. Use of electron microscopy to classify canine perivascular wall tumors. Vet Pathol 50, 226–233.

Pritchard C, Al-Nadaf S, Rebhun RB, Willcox JL, Skorupski KA, Lejeune A, 2023. Efficacy and toxicity of carboplatin in the treatment of macroscopic mesenchymal neoplasia in dogs. Vet Comp Oncol 21, 717–725.

Pucket JD, Allbaugh RA, Higginbotham ML, Rankin AJ, Teixeira L, 2017. Metastatic intraocular hemangiopericytoma in a dog. Open Vet J 7, 132-138.

da Silva EO, Romero F, Green KT, Martins MIM, Bracarense A, 2014. Hemangiopericytoma in a female dog with direct invasion of abdominal cavity and pulmonary metastasis. Ciência Rural 44, 358–361.

Sisó S, Marco-Salazar P, Roccabianca P, Avallone G, Higgins RJ, Affolter VK, 2023. Nerve fiber immunohistochemical panel discriminates between nerve sheath and perivascular wall tumors. Vet Sci 10, 1.

Vignoli M, Buchholz J, Morandi F, Laddaga E, Brunetti B, Rossi F, Terragni R, Sarli G, 2008. Primary pulmonary spindle cell tumour (haemangiopericytoma) in a dog. J Small Anim Pract 49, 540–543.