Anthelminthic drug efficacy evaluation Ivermectin double dose, Ivermectin with clorsulon and Levamisole in Alpine Goats
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Abstract
Objective: This study was to evaluate the efficacy of anthelminthics (Ivermectin double shot, Ivermectin with Clorsulon and Levamisole) in Alpine goats by field trial study.
Materials and Methods: At Pattani Livestock Research and Breed Centre, 40 goats were grouped and separated into 4 treatments by different drugs (No treatment/Control, Ivermectin 0.2 mg/kg, Ivermectin with Clorsulon 0.2 mg/kg and Levamisole 8 mg/kg) in subcutaneous route on day 0 except Ivermectin group was given 2 shots on day 0 and 3 of the experiment. Fecal sampling was performed individually on day 0, 3, 7, 14, 21 and 28 of the study for count egg worms to estimate amount of egg worms in 1 gram of feces (Egg count per Gram; EPG unit) via McMaster technique. The amount of egg reduction was calculated in percentage in each period. Fecal egg count reduction (FECR) was utilized for the efficacy and resistance level in each group.
Results: The results found strongyle and strongyloides egg worms type, and the average egg amount before treatment were 1,460 (200-3,900) EPG with no difference between groups. After Day 3, egg count was significantly reduced in treatment groups (average egg amount 923, range 50-2,700) compared with the control group. In levamisole treatment group presented an average EPG amount was 10 (0-50), that was lowest and significantly decreased (P<0.01) when compared between groups and the maximum of FECR was 99.38 on day 14. In Ivermectin with Clorsulon group shows an average EPG amount in the period was 75(0-200), the maximum FECR was 92.10 on day 21. In Ivermectin double shot group presented an average EPG amount was 700(100-1,700) and the maximum FECR was 35.7.
Conclusion: FECR in each group indicates anthelmintics resistance and efficacy, Levamisole was a highly effective to control parasites in the gastrointestinal tract of goats. Ivermectin and Ivermectin with clorsuron group showed resistance anthelminthics except Levamisole. Therefore, Levamisole is a highly effective in controlling parasites in goats' gastrointestinal tract.
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