ระบาดวิทยาของโรคไข้คิวในสัตว์เคี้ยวเอื้อง ในภาคตะวันออกเฉียงเหนือและภาคเหนือของประเทศไทย ปี 2555-2556
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เผยแพร่แล้ว:
ก.ค. 20, 2018
คำสำคัญ:
โรคไข้คิว สัตว์เคี้ยวเอื้อง ภาคเหนือ ภาคตะวันออกเฉียงเหนือ ประเทศไทย
Main Article Content
บทคัดย่อ
วัตถุประสงค์: ผู้วิจัยจึงต้องการศึกษาสถานะของโรคไข้คิวในสัตว์เคี้ยวเอื้องในภาคตะวันออกเฉียงเหนือและภาคเหนือของประเทศไทย
วัสดุ อุปกรณ์ และวิธีการ: เก็บรกโค กระบือ แพะ แกะ และสัตว์ป่าที่เป็นสัตว์เคี้ยวเอื้องในปี 2555 ถึง 2556 โดย convenience sampling จากทั้งสองภาค รวม 1,044 ตัวอย่าง สังเกตรอยโรค จากนั้นสกัด DNA จากตัวอย่างรกและนำมาตรวจหา ยีน IS1111 ของ Coxeilla burnetii ด้วยเทคนิค real-time PCR
ผลการศึกษา: ตัวอย่างไม่มีรอยโรคที่มองเห็นได้ด้วยตาเปล่า ผลบวกที่พบภาพรวม คือ 76.63% (800/1044) โดยภาคตะวันออกเฉียงเหนือพบรกที่ให้ผลบวกเท่ากับ 76.19% (685/899) และภาคเหนือพบรกที่ให้ผลบวกเท่ากับ 79.31% (115/145)
ข้อสรุป: การศึกษาครั้งนี้บ่งชี้ว่ารกที่เก็บจากสัตว์เคี้ยวเอื้องในภาคตะวันออกเฉียงเหนือและภาคเหนือให้ผลบวกต่อเชื้อ C. burnetii ด้วยวิธี real-time PCR โดยสัตว์ไม่แสดงอาการแท้ง ทั้งนี้ผลบวกที่สูง อาจเกิดจากรกที่ปนเปื้อนเชื้อบนวัสดุปูรอง สิ่งปฏิกูล และสิ่งแวดล้อม ดังนั้นการศึกษาในอนาคต ควรนำวิธี immunohistochemistry มาศึกษาร่วมด้วยซึ่งจะสามารถระบุถึงการติดเชื้อที่รกได้ชัดเจนมากขึ้นด้วย
Article Details
ประเภทบทความ
บทความวิจัย
เอกสารอ้างอิง
Anderson, A., Bijlmer, H., Fournier, P.-E., Graves, S., Hartzell, J., Kersh, G.J., Limonard, G., Marrie, T.J., Massung, R.F., McQuiston, J.H., 2013. Diagnosis and management of Q fever—United States, 2013: recommendations from CDC and the Q Fever Working Group. MMWR 62, 1-30.
Angelakis, E., Raoult, D., 2010. Q Fever. Vet Microbiol 140, 297-309.
Christensen, D.R., Hartman, L.J., Loveless, B.M., Frye, M.S., Shipley, M.A., Bridge, D.L., Richards, M.J., Kaplan, R.S., Garrison, J., Baldwin, C.D., Kulesh, D.A., Norwood, D.A., 2006. Detection of Biological Threat Agents by Real-Time PCR: Comparison of Assay Performance on the R.A.P.I.D., the LightCycler, and the Smart Cycler Platforms. Clinical chemistry 52, 141.
DLD 2011a. Data of beef cow farmers by regional livestock, budget year 2011, center, I.a.c.t., ed. (Department of livestock development).
DLD 2011b. Data of buffalo and pig farmers by regional livestock, budget year 2011 (Information and communication technology center).
DLD 2011c. Data of dairy cow farmers by regional livestock, budget year 2011 (Information and communication technology center).
DLD 2011d. Data of goat and sheep farmers by regional livestock, budget year 2011 (Information and communication technology center).
Doung-ngern, P., Chuxnum, T., Pangjai, D., Opaschaitat, P., Kittiwan, N., Rodtian, P., Buameetoop, N., Kersh, G.J., Padungtod, P., 2017. Seroprevalence of Coxiella burnetii Antibodies among Ruminants and Occupationally Exposed People in Thailand, 2012–2013. The American journal of tropical medicine and hygiene, -.
Georgiev, M., Afonso, A., Neubauer, H., Needham, H., Thiery, R., Rodolakis, A., Roest, H., Stark, K., Stegeman, J., Vellema, P., van der Hoek, W., More, S., 2013. Q fever in humans and farm animals in four European countries, 1982 to 2010. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 18.
Kersh, G.J., Wolfe, T.M., Fitzpatrick, K.A., Candee, A.J., Oliver, L.D., Patterson, N.E., Self, J.S., Priestley, R.A., Loftis, A.D., Massung, R.F., 2010. Presence of Coxiella burnetii DNA in the environment of the United States, 2006 to 2008. Applied and environmental microbiology 76, 4469-4475.
Nielsen, S.Y., Molbak, K., Nybo Andersen, A.M., Brink Henriksen, T., Kantso, B., Krogfelt, K.A., Hjollund, N.H., 2013. Prevalence of Coxiella burnetii in women exposed to livestock animals, Denmark, 1996 to 2002. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 18.
OIE 2010. Q fever. In OIE terrestrial manual 2010, 1-13.
OIE. 2016. Q fever, In: Manual of Diagnostic Tests and Vaccines for Terrestrial Animal 2016. https://www.oie.int/fileadmin/Home/eng/Health_standards/tahm/2.01.16_Q_FEVER.pdf, 1-15.
Ormsbee, R., Peacock, M., Gerloff, R., Tallent, G., Wike, D., 1978. Limits of rickettsial infectivity. Infection and immunity 19, 239-245.
Pachirat, O., Fournier, P.E., Pussadhamma, B., Taksinachanekij, S., Lulitanond, V., Baggett, H.C., Thamthitiwat, S., Watt, G., Raoult, D., Maloney, S.A., 2012. The first reported cases of Q fever endocarditis in Thailand. Infectious disease reports 4, e7.
Paul, S., Agger, J.F., Markussen, B., Christoffersen, A.B., Agerholm, J.S., 2012. Factors associated with Coxiella burnetii antibody positivity in Danish dairy cows. Prev Vet Med 107, 57-64.
Porter, S.R., Czaplicki, G., Mainil, J., Horii, Y., Misawa, N., Saegerman, C., 2011. Q fever in Japan: an update review. Vet Microbiol 149, 298-306.
Rai, S.B., F, K., TS, C., CK, Y., 2011. First documented zoonotic case of Q fever in Penang, Malaysia. Outbreak, Surveillance and Investigation Reports 4, 1-5.
Reichel, R., Mearns, R., Brunton, L., Jones, R., Horigan, M., Vipond, R., Vincent, G., Evans, S., 2012. Description of a Coxiella burnetii abortion outbreak in a dairy goat herd, and associated serology, PCR and genotyping results. Res Vet Sci 93, 1217-1224.
Rodolakis, A., 2006. Q fever, state of art: Epidemiology, diagnosis and prophylaxis. Small Ruminant Research 62, 121-124.
Roest, H.J., van Gelderen, B., Dinkla, A., Frangoulidis, D., van Zijderveld, F., Rebel, J., van Keulen, L., 2012. Q fever in pregnant goats: pathogenesis and excretion of Coxiella burnetii. PloS one 7, e48949.
Suputtamongkol, Y., Rolain, J.-M., Losuwanaruk, K., Niwatayakul, K., Suthinont, C., Chierakul, W., Pimda, K., Raoult, D., 2003. Q Fever in Thailand. Emerging Infectious Diseases 9, 1186-1188.
Taurel, A.-F., Guatteo, R., Joly, A., Seegers, H., Beaudeau, F., 2011. Seroprevalence of Q fever in naturally infected dairy cattle herds. Preventive Veterinary Medicine 101, 51-57.
van der Hoek, W., Dijkstra, F., Schimmer, B., Schneeberger, P.M., Vellema, P., Wijkmans, C., ter Schegget, R., Hackert, V., van Duynhoven, Y., 2010. Q fever in the Netherlands: an update on the epidemiology and control measures. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 15.
Watt, G., Pachirat, O., Baggett, H.C., Maloney, S.A., Lulitanond, V., Raoult, D., Bhengsri, S., Thamthitiwat, S., Paupairoj, A., Kosoy, M., Ud-Ai, N., Sukwicha, W., Whistler, T., Fournier, P.E., 2014. Infective endocarditis in northeastern Thailand. Emerg Infect Dis 20, 473-476.
Whitney, E.A., Massung, R.F., Candee, A.J., Ailes, E.C., Myers, L.M., Patterson, N.E., Berkelman, R.L., 2009. Seroepidemiologic and occupational risk survey for Coxiella burnetii antibodies among US veterinarians. Clin Infect Dis 48, 550-557.
Whitney, E.A., Massung, R.F., Kersh, G.J., Fitzpatrick, K.A., Mook, D.M., Taylor, D.K., Huerkamp, M.J., Vakili, J.C., Sullivan, P.J., Berkelman, R.L., 2013. Survey of laboratory animal technicians in the United States for Coxiella burnetii antibodies and exploration of risk factors for exposure. Journal of the American Association for Laboratory Animal Science : JAALAS 52, 725-731.
Woldehiwet, Z., 2004. Q fever (coxiellosis): epidemiology and pathogenesis. Research in Veterinary Science 77, 93-100.
Angelakis, E., Raoult, D., 2010. Q Fever. Vet Microbiol 140, 297-309.
Christensen, D.R., Hartman, L.J., Loveless, B.M., Frye, M.S., Shipley, M.A., Bridge, D.L., Richards, M.J., Kaplan, R.S., Garrison, J., Baldwin, C.D., Kulesh, D.A., Norwood, D.A., 2006. Detection of Biological Threat Agents by Real-Time PCR: Comparison of Assay Performance on the R.A.P.I.D., the LightCycler, and the Smart Cycler Platforms. Clinical chemistry 52, 141.
DLD 2011a. Data of beef cow farmers by regional livestock, budget year 2011, center, I.a.c.t., ed. (Department of livestock development).
DLD 2011b. Data of buffalo and pig farmers by regional livestock, budget year 2011 (Information and communication technology center).
DLD 2011c. Data of dairy cow farmers by regional livestock, budget year 2011 (Information and communication technology center).
DLD 2011d. Data of goat and sheep farmers by regional livestock, budget year 2011 (Information and communication technology center).
Doung-ngern, P., Chuxnum, T., Pangjai, D., Opaschaitat, P., Kittiwan, N., Rodtian, P., Buameetoop, N., Kersh, G.J., Padungtod, P., 2017. Seroprevalence of Coxiella burnetii Antibodies among Ruminants and Occupationally Exposed People in Thailand, 2012–2013. The American journal of tropical medicine and hygiene, -.
Georgiev, M., Afonso, A., Neubauer, H., Needham, H., Thiery, R., Rodolakis, A., Roest, H., Stark, K., Stegeman, J., Vellema, P., van der Hoek, W., More, S., 2013. Q fever in humans and farm animals in four European countries, 1982 to 2010. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 18.
Kersh, G.J., Wolfe, T.M., Fitzpatrick, K.A., Candee, A.J., Oliver, L.D., Patterson, N.E., Self, J.S., Priestley, R.A., Loftis, A.D., Massung, R.F., 2010. Presence of Coxiella burnetii DNA in the environment of the United States, 2006 to 2008. Applied and environmental microbiology 76, 4469-4475.
Nielsen, S.Y., Molbak, K., Nybo Andersen, A.M., Brink Henriksen, T., Kantso, B., Krogfelt, K.A., Hjollund, N.H., 2013. Prevalence of Coxiella burnetii in women exposed to livestock animals, Denmark, 1996 to 2002. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 18.
OIE 2010. Q fever. In OIE terrestrial manual 2010, 1-13.
OIE. 2016. Q fever, In: Manual of Diagnostic Tests and Vaccines for Terrestrial Animal 2016. https://www.oie.int/fileadmin/Home/eng/Health_standards/tahm/2.01.16_Q_FEVER.pdf, 1-15.
Ormsbee, R., Peacock, M., Gerloff, R., Tallent, G., Wike, D., 1978. Limits of rickettsial infectivity. Infection and immunity 19, 239-245.
Pachirat, O., Fournier, P.E., Pussadhamma, B., Taksinachanekij, S., Lulitanond, V., Baggett, H.C., Thamthitiwat, S., Watt, G., Raoult, D., Maloney, S.A., 2012. The first reported cases of Q fever endocarditis in Thailand. Infectious disease reports 4, e7.
Paul, S., Agger, J.F., Markussen, B., Christoffersen, A.B., Agerholm, J.S., 2012. Factors associated with Coxiella burnetii antibody positivity in Danish dairy cows. Prev Vet Med 107, 57-64.
Porter, S.R., Czaplicki, G., Mainil, J., Horii, Y., Misawa, N., Saegerman, C., 2011. Q fever in Japan: an update review. Vet Microbiol 149, 298-306.
Rai, S.B., F, K., TS, C., CK, Y., 2011. First documented zoonotic case of Q fever in Penang, Malaysia. Outbreak, Surveillance and Investigation Reports 4, 1-5.
Reichel, R., Mearns, R., Brunton, L., Jones, R., Horigan, M., Vipond, R., Vincent, G., Evans, S., 2012. Description of a Coxiella burnetii abortion outbreak in a dairy goat herd, and associated serology, PCR and genotyping results. Res Vet Sci 93, 1217-1224.
Rodolakis, A., 2006. Q fever, state of art: Epidemiology, diagnosis and prophylaxis. Small Ruminant Research 62, 121-124.
Roest, H.J., van Gelderen, B., Dinkla, A., Frangoulidis, D., van Zijderveld, F., Rebel, J., van Keulen, L., 2012. Q fever in pregnant goats: pathogenesis and excretion of Coxiella burnetii. PloS one 7, e48949.
Suputtamongkol, Y., Rolain, J.-M., Losuwanaruk, K., Niwatayakul, K., Suthinont, C., Chierakul, W., Pimda, K., Raoult, D., 2003. Q Fever in Thailand. Emerging Infectious Diseases 9, 1186-1188.
Taurel, A.-F., Guatteo, R., Joly, A., Seegers, H., Beaudeau, F., 2011. Seroprevalence of Q fever in naturally infected dairy cattle herds. Preventive Veterinary Medicine 101, 51-57.
van der Hoek, W., Dijkstra, F., Schimmer, B., Schneeberger, P.M., Vellema, P., Wijkmans, C., ter Schegget, R., Hackert, V., van Duynhoven, Y., 2010. Q fever in the Netherlands: an update on the epidemiology and control measures. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 15.
Watt, G., Pachirat, O., Baggett, H.C., Maloney, S.A., Lulitanond, V., Raoult, D., Bhengsri, S., Thamthitiwat, S., Paupairoj, A., Kosoy, M., Ud-Ai, N., Sukwicha, W., Whistler, T., Fournier, P.E., 2014. Infective endocarditis in northeastern Thailand. Emerg Infect Dis 20, 473-476.
Whitney, E.A., Massung, R.F., Candee, A.J., Ailes, E.C., Myers, L.M., Patterson, N.E., Berkelman, R.L., 2009. Seroepidemiologic and occupational risk survey for Coxiella burnetii antibodies among US veterinarians. Clin Infect Dis 48, 550-557.
Whitney, E.A., Massung, R.F., Kersh, G.J., Fitzpatrick, K.A., Mook, D.M., Taylor, D.K., Huerkamp, M.J., Vakili, J.C., Sullivan, P.J., Berkelman, R.L., 2013. Survey of laboratory animal technicians in the United States for Coxiella burnetii antibodies and exploration of risk factors for exposure. Journal of the American Association for Laboratory Animal Science : JAALAS 52, 725-731.
Woldehiwet, Z., 2004. Q fever (coxiellosis): epidemiology and pathogenesis. Research in Veterinary Science 77, 93-100.
