Hemostatic disorders in canine monocytic ehrlichiosis
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Abstract
Objective: The aims of this study were (1) to compare platelet count, APTT (activated partial thromboplastin time) and PT (prothrombin time) between healthy dogs and dogs with canine monocytic ehrlichiosis (CME), and (2) to study whether any coagulation factor defects occur in dogs with the disease.
Materials and Methods: Blood samples were obtained from 20 clinically healthy dogs and 18 CME dogs. Some coagulation profiles and platelet count were measured by an automatic blood coagulation analyzer and an automatic analyzer, respectively. When the PT or APTT was prolonged, substitution test would be performed.
Results: Significant increases in APTT (P<0.01) and decreases in platelet count (P<0.01) for ehrlichiotic dogs were observed. However, no significant differences in PT among Ehrlichia-infected and healthy dogs were found. Furthermore, by substitution test (APTT), 2 of 18 cases (11.1%) possibly had revealed Factor IX defect and 1 of 18 cases (5.6%) possibly had Factor XI or XII defect, and both had factor deficiencies.
Conclusion: Defects of some coagulation factors may be involved in the pathophysiology of canine monocytic ehrlichiosis.
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References
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