Factors Influencing Syphilis Infection in Pregnant Women

Main Article Content

Manitra Mensin
Nanthana Thananowan
Piyanun Limruangrong

Abstract

This case-control study aimed to determine predictive powers of age, substance abuse, number of sexual partners, knowledge about syphilis, social support, depressive symptoms, and intimate partner violence on syphilis infection in pregnant women. The sample consisted of 196 pregnant women who received antenatal care at hospitals in Bangkok districts and divided into the case group (n = 50) with syphilis infection and the control group (n = 146) without syphilis infection. Data were collected by using: 1) the Personal Data Questionnaire, 2) the Knowledge about Syphilis Questionnaire, 3) the Medical Outcomes Study: Social Support Survey (MOS-SSS), 4) the Center for Epidemiologic Studies-Depression Scale (CES-D), and 5) the Abuse Assessment Screen (AAS). The reliabilities of the second-fifth questionnaire were .78, .94, .92, and .82, respectively. Data were analyzed using descriptive statistics, chi-square tests, and multiple logistic regression analysis.


The findings revealed that age, substance abuse, number of sexual partners, knowledge about syphilis, social support, depressive symptoms, and intimate partner violence could significantly predict 50.50% (R2 = .505) of syphilis infection in pregnant women. The findings of this study suggested that midwives should assess risk factors among pregnant women aged 18 - 24 years who had multiple sexual partners, used substances, or were abused by intimate partners to reduce adverse outcomes from syphilis infection during pregnancy.

Article Details

How to Cite
1.
Mensin M, Thananowan N, Limruangrong P. Factors Influencing Syphilis Infection in Pregnant Women. KJN [Internet]. 2024 Nov. 27 [cited 2024 Dec. 4];31(2):266-80. Available from: https://he01.tci-thaijo.org/index.php/kcn/article/view/273144
Section
Research Articles

References

World Health Organization. Report on global sexually transmitted infection surveillance 2018 [Internet]. 2018 [cited 2023 Apr 1]. Available from: https://www.who.int/publications/i/item/9789241565691

Punpetch S, Sawangsuk J, Pansuwan N, Kittiyaowamarn R. Epidemiology of congenital syphilis under the five dimensions of the disease and health hazard surveillance system in Thailand, 2019. Thai AIDS Journal 2022;34(3):144-61. (in Thai)

Chaisongkram N. Epidemiological characteristics among patients with syphilis in Thailand. Disease Control Journal 2023;49(1):51-61. doi: 10.14456/dcj.2023.5. (in Thai)

Nilphat C, Boonshuyar C. Prevalence and risk factors of congenital syphilis infection in Thailand during A.D. 2016-2021. Thai AIDS Journal 2023;35(3):151-9. doi: 10.14456/taj.2023.13. (in Thai)

Onpiw N, Naosrisorn P, Sinthusiri P. Syphilis in pregnancy: nurse’s roles. Journal of The Royal Thai Army Nurse 2020;21(3):1-10. (in Thai)

Pillay S, Tooke LJ. Symptomatic congenital syphilis in a tertiary neonatal unit in Cape town, South Africa: high morbidity and mortality in a preventable disease. South African Medical Journal 2019;109(9):652-8. doi: 10.7196/SAMJ.2019.v109i9.13817.

Tongsong T. Obstetrics. 6th ed. Bangkok: Laxmirung Press; 2021. (in Thai)

Befekadu B, Shuremu M, Zewdie A. Seroprevalence of syphilis and its predictors among pregnant women in Buno Bedele zone, Southwest Ethiopia: a community-based cross-sectional study. BMJ Open 2022;12(8):e063745. doi: 10.1136/bmjopen-2022-063745.

Benedetti KCSV, Ribeiro ADC, Queiroz JHFS, Melo ABD, Batista RB, Delgado FM, et al. High prevalence of syphilis and inadequate prenatal care in Brazilian pregnant women: a cross-sectional study. American Journal of Tropical Medicine and Hygiene 2019;101(4):761-6. doi: 10.4269/ajtmh.18-0912.

Lendado TA, Tekle T, Dawit D, Daga WB, Diro CW, Arba MA, et al. Determinants of syphilis infection among pregnant women attending antenatal care in hospitals of Wolaita zone, Southern Ethiopia, 2020. Plos One 2022;17(6):e0269473. doi: 10.1371/journal.pone.0269473.

Ajayi OH, Ajayi I, Dada-Adegbola H. Prevalence and risk factors of HIV and syphilis among pregnant women in ado local government, Ekiti state, South Western Nigeria-2017. Journal of Labor and Childbirth 2018;1(2):1-6.

Defilipo ÉC, Chagas PSC, Ribeiro LC. Violence against pregnant women and associated factors in the city of Governador Valadares. Revista de Saude Publica 2020;54:135. doi: 10.11606/s1518-8787.2020054002491.

Rigo FL, Romanelli RMC, Oliveira IP, Anchieta LM. Assistance and educational factors associated to congenital syphilis in a referral maternity: a case-control study. Revista Brasileira De Saúde Materno Infantil 2021;21(1):127-37. doi: 10.1590/1806-93042021000100007.

Peltzer K, Shikwane E, Matseke G. Psychological distress and associated factors among a sample of pregnant women in South Africa. Journal of Psychology in Africa 2011;21(3):495-9. doi: 10.1080/14330237.2011.10820489.

Wabe YA, Reda DY, Ail MM. Seroprevalence of syphilis and HBV among pregnant women at Saint Paul’s hospital millennium medical college, Addis Ababa Ethiopia. Primary Health Care: Open Access 2021;11(7):392. doi: 10.35248/2167-1079.21.7.392.

Kurita T. Cervix: cell biology. In: Skinner MK, editor. Encyclopedia of reproduction. 2nd. ed. Washington: Academic Press; 2018. p. 347-52.

Geremew H, Geremew D. Sero-prevalence of syphilis and associated factors among pregnant women in Ethiopia: a systematic review and meta-analysis. Systematic Reviews 2021;10:223. doi: 10.1186/s13643-021-01786-3.

Odagami M, Iwata A, Kubota K, Kurasawa K, Okuda M, Aoki S, et al. Awareness of infectious disease screening during early pregnancy and knowledge about its vertical transmission in Japan: a report from the pregnant women health initiative. Maternal and Child Health Journal 2023;27(5):933-43. doi: 10.1007/s10995-023-03597-5.

Kuugbee ED, Maaldu G, Adamu A, Salia N, Walana W, Kampo S, et al. Seroprevalence and risk factors of sexually transmitted blood-borne infections among pregnant women attending antenatal care in Jirapa, upper West region of Ghana. Canadian Journal of Infectious Diseases and Medical Microbiology 2023;3157202. doi: 10.1155/2023/3157202.

Daniels E, Atkinson A, Cardoza N, Ramakrishnan A, Willers D, Reno H. Social factors associated with congenital syphilis in Missouri. Clinical Infectious Diseases 2024;79(3):744-50. doi: 10.1093/cid/ciae260.

Xu C, Shi Y, Yu X, Chang R, Wang H, Chen H, et al. The syndemic condition of psychosocial problems related to depression among sexually transmitted infections patients. Peer Journal 2021;9:e12022. doi: 10.7717/peerj.12022.

Thananowan N, Vongsirimas N, Rachapromma P. Intimate partner violence and factors associated with sexually transmitted infections among Thai women attending gynecology clinics. International Journal of STD and AIDS 2021;32(4)336-43. doi: 10.1177/0956462420966136.

Agarwal S, Prasad R, Mantri S, Chandrakar R, Gupta S, Babhulkar V, et al. A comprehensive review of intimate partner violence during pregnancy and its adverse effects on maternal and fetal health. Cureus 2023;15(5):e39262. doi: 10.7759/cureus.39262.

Rosner B. Fundamentals of biostatistics. 7th ed. Boston: Cengage Learning Inc; 2010.

Glass GV. Standards and criteria. Journal of Educational Measurement 2005;15(4):237-61.

Sherbourne CD, Stewart AL. The MOS social support survey. Social science and Medicine 1991;32(6):705-14. doi: 10.1016/0277-9536(91)90150-b.

Rungruangsiripan M, Sitthimongkol Y, Maneesriwongul W, Talley S, Vorapongsathorn T. Mediating role of illness representation among social support, therapeutic alliance, experience of medication side effects and medication adherence in persons with schizophrenia. Archives of Psychiatric Nursing 2011;25(4):269-83. doi: 10.1016/j.apnu.2010.09.002.

Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Applied Psychological Measurement 1997;1(3):385-401. doi: 10.1177/014662167700100306.

Trangkasombat U, Larpboonsarp V, Havanond P. CES-D as a screen for depression in adolescents. Journal of the Psychiatric Association of Thailand 1997;42(1):2-13. (in Thai)

McFarlane J, Parker B, Soeken K, Bullock L. Assessing for abuse during pregnancy. Severity and frequency of injuries and associated entry into prenatal care. JAMA 1992;267(23):3176-8. doi: 10.1001/jama.1992.03480230068030.

Thananowan N. Intimate partner violence (IPV) among Thai pregnant women: the correlation of violence with maternal characteristics, health practices during pregnancy, and maternal health [Dissertation]. Wisconsin: University of Wisconsin-Madison; 2004.

Erazo-Medina LL, García-Cajaleón JD, SoteloMuñoz SA, Rivera-Beltrán SE, Reyes-Ortiz SC, Campos-Correa KE. Gestational syphilis: analysis of risk factors in a maternal and child center in Lima, Peru (2015-2020). Ginecología y Obstetricia de México 2022;90(11):901-9. doi: 10.24245/gom.v90i11.8154.

Hakizimana T, Muhumuza J, Selamo FM, Ishimwe MPS, Kajabwangu R, Jelle OM, et al. Prevalence and factors associated with syphilis among mothers with missed opportunities for antenatal syphilis testing in rural Western Uganda: a cross-sectional study. International Journal of Reproductive Medicine 2023;2971065. doi: 10.1155/2023/2971065.

Sabin L, Haghparast-Bidgoli H, Miller F, Saville N. A systematic review of barriers and facilitators to antenatal screening for HIV, syphilis or hepatitis B in Asia: perspectives of pregnant women, their relatives and health care providers. PLoS ONE 2024;19(5):e0300581. doi: 10.1371/journal.pone.0300581.

Nugrahaeni MT, Prasetya H, Murti B. Effects of marital status and social support on antenatal depression: a meta-analysis. Journal of Health Promotion and Behavior 2023;8(2):102-15. doi: 10.26911/thejhpb.2023.08.02.05.