Factors Associated with Clinical Sequelae of COVID-19 Survivors at a Secondary-Level Hospital in Central Thailand
Main Article Content
Abstract
Long COVID is one of the biggest challenges for healthcare professionals caring for COVID-19 survivors. However, research studies regarding this issue in Thailand are limited. Therefore, this study aimed to explore factors associated with the clinical sequelae of COVID-19 survivors. A total of 268 COVID-19 survivors aged over 20 who received service at a secondary-level hospital in central Thailand were recruited into the study. Data were obtained from medical records and using three questionnaires to measure the feelings of loneliness, stigma, and clinical sequelae that persisted after COVID-19 infection. To determine the associations between reported clinical sequelae and selected factors, Chi-square and Fisher’s exact test was used.
The result shown among the 268 COVID-19 survivors, 167 (62.31%) reported having Long COVID. Symptoms often reported were fatigue (44.78%), memory loss (26.12%), tachypnea after activity (23.88%), joint pain (22.39%), and sleep disorder (22.39%). Factors significantly associated with long COVID (p-value < .05) were 1) male gender, 2) BMI ≥ 25 kg/m2, 3) Charlson Comorbidity Index (CCI) > 4, 4) having severe disease of COVID-19, 5) receiving antiviral drugs, 6) requiring oxygen with cannula support 6) having loneliness and 7) having stigma. Nurses and healthcare professionals taking care of this group of patients should be aware of these factors and use them to determine whether an individual is at risk of long-term COVID-19 symptoms. Nursing practice guidelines for long-term COVID-19 symptoms often reported should be developed as well.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
World Health Organization. Coronavirus disease (COVID-19) [Internet]. 2022 [cited 2022 Jan 27]. Available from: https://www.who.int/thailand/emergencies/novel-coronavirus-2019/q-a-on-covid-19
Department of Disease Control. Coronavirus (COVID-19) infection [Internet]. 2022 [cited 2022 Jan 27]. Available from: https://ddc.moph.go.th/viralpneumonia/index.php (in Thai)
Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo PA, Cuapio A, et al. More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. medRxiv 2021;11:16144. doi: 10.1101/2021.01.27.21250617.
Taquet M, Dercon Q, Luciano S, Geddes JR, Husain M, Harrison PJ. Incidence, co-occurrence, and evolution of long-COVID features: a 6-month retrospective cohort study of 273,618 survivors of COVID-19. PLoS Medicine 2021;18(9):e1003773. doi: 10.1371/journal.pmed.1003773.
Carfi A, Bernabei R, Landi F. Persistent symptoms in patients after acute COVID-19. JAMA 2020;324(6):603-5. doi: 10.1001/jama.2020.12603.
Xiong Q, Xu M, Li J, Liu Y, Zhang J, Xu Y, et al. Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study. Clinical Microbiology and Infection 2021;27(1):89-95. doi: 10.1016/j.cmi.2020.09.023.
Boscolo-Rizzo P, Guida F, Polesel J, Marcuzzo AV, Capriotti V, D’Alessandro A, et al. Sequelae in adults at 12 months after mild-to-moderate coronavirus disease 2019 (COVID-19). International Forum of Allergy and Rhinology 2021;11(12):1685-8. doi: 10.1002/alr.22832.
Huang L, Yao Q, Gu X, Wang Q, Ren L, Wang Y, et al. 1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study. Lancet 2021;398(10302):747-58. doi: 10.1016/S0140-6736(21)01755-4.
Channarong M. Factors relating to post discharge persistence of symptoms after hospitalization among persons with coronavirus disease 2019. Journal of Health and Nursing Education 2022;28(1):e257651. (in Thai)
Zhang X, Wang F, Shen Y, Zhang X, Can Y, Wang B, et al. Symptoms and health outcomes among survivors of COVID-19 infection 1 year after discharge from hospitals in Wuhan, China. JAMA Network Open 2021;4(9):e2127403. doi: 10.1001/jamanetworkopen.2021.27403.
Tleyjeh IM, Saddik B, AlSwaidan N, AlAnazi A, Ramakrishnan RK, Alhazmi D, et al. Prevalence and predictors of post-acute COVID-19 syndrome (PACS) after hospital discharge: a cohort study with 4 months median follow-up. PLoS ONE 2021;16(12):e0260568. doi: 10.1371/journal.pone.0260568.
Han J, Richardson V. The relationship between depression and loneliness among homebound older persons: does spirituality moderate this relationship?. Journal of Religion and Spirituality in Social Work: Social Thought 2010;29(3):218-36. doi: 10.1080/15426432.2010.495610.
Wahyuhadi J, Efendi F, Farabi MJA, Harymawan I, Ariana AD, Arifin H, et al. Association of stigma with mental health and quality of life among Indonesian COVID-19 survivors. PLOS ONE 2022;17(2):e0264218. doi: 10.1371/journal.pone.0264218.
Rogers JP, Chesney E, Oliver D, Pollak TA, McGuire P, Fusar-Poli P, et al. Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic. The Lancet Psychiatry 2020;7(7):611-27. doi: 10.1016/S2215-0366(20)30203-0.
Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. The Lancet Journal 2020;395(10227):912-20. doi: 10.1016/S0140-6736(20)30460-8.
Charlson ME, Charlson RE, Peterson JC, Marinopoulos SS, Briggs WM, Hollenberg JP. The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients. Journal of Clinical Epidemiology 2008;61(12):1234-40. doi: 10.1016/j.jclinepi.2008.01.006.
Department of Medical Sciences, Ministry of Public Health of Thailand. Guidelines for clinical practice, diagnosis, treatment and prevention of healthcare-associated infection in response to patients with COVID-19 infection [Internet]. 2022 [cited 2022 Oct 27]. Available from: https://covid19.dms.go.th/backend///Content//Content_File/Covid_Health/Attach/25650929256509PM_CPG_COVID-19_v.25_n_20220929.pdf (in Thai)
Kaewpijit U. The effects of a social relationship program on the loneliness of older persons [Dissertation]. Bangkok: Thammasat University; 2017. (in Thai)
Russell D, Cutrona CE, Rose J, Yurko K. Social and emotional loneliness: an examination of Weiss’s typology of loneliness. Journal of Personality and Social Psychology 1984;46(6):1313-21. doi: 10.1037//0022-3514.46.6.1313.
Wahl OF. Mental health consumers’ experience of stigma. Schizophrenia Bulletin 1999;25(3):467-78. doi: 10.1093/oxfordjournals.schbul.a033394.
Wannachat O. Life skills as perceived by caregivers, social support and perceived stigma among persons with schizophrenia [Dissertation]. Chiang Mai: Chiang Mai University; 2007. (in Thai)
Ngo ST, Steyn FJ, McCombe PA. Gender differences in autoimmune disease. Frontiers in Neuroendocrinology 2014;35(3):347-69. doi: 10.1016/j.yfrne.2014.04.004.
Lim S, Shin SM, Nam GE, Jung CH, Koo BK. Proper management of people with obesity during the COVID-19 pandemic. Journal of Obesity and Metabolic Syndrome 2020;29(2):84-98. doi: 10.7570/jomes20056.
Lacavalerie MR, Pierre-Francois S, Agossou M, Inamo J, Cabie A, Barnay JL, et al. Obese patients with long COVID-19 display abnormal hyperventilatory response and impaired gas exchange at peak exercise. Future Cardiology 2022;18(7):577-84. doi: 10.2217/fca-2022-0017.
Pretorius E, Venter C, Gert JL, Laubscher GJ, Kotze MJ, Oladejo SO, et al. Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with long COVID/Post-Acute Sequelae of COVID-19 (PASC). Cardiovascular Diabetology 2022;21(1):148 doi: 10.1186/s12933-022-01579-5.
Turner S, Khan MA, Putrino D, Woodcock A, Kell DB, Pretorius E. Long COVID: pathophysiological factors and abnormalities of coagulation. Trends in Endocrinology and Metabolism 2023;34(6):321-44. doi: 10.1016/j.tem.2023.03.002.
Wang S, Quan L, Chavarro JE, Slopen N, Kubzansky LD, Koenen KC, et al. Associations of depression, anxiety, worry, perceived stress, and loneliness prior to infection with risk of post-COVID-19 conditions. JAMA Psychiatry 2022;79(11):1081-91. doi: 10.1001/jamapsychiatry.2022.2640.
Zhou M. COVID-19-related stigma and its impact on psychological distress: a cross-sectional study in Wuhan, China. Health Science Reports 2022;5(5):e758. doi: 10.1002/hsr2.758.
Yuan Y, Zhao YJ, Zhang QE, Zhang L, Cheung T, Jackson T, et al. COVID-19-related stigma and its sociodemographic correlates: a comparative study. Globalization and Health 2021;17(1):54. doi: 10.1186/s12992-021-00705-4.