Factors Predicting Postoperative Complication in Patients with Ruptured Cerebral Aneurysms

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Atchara Srinukul
Suporn Danaidutsadeekul
Wallada Chanruangvanich
Thaweesak Aurboonyawat

Abstract

This cross-sectional descriptive research aimed to determine the factors predicting intraoperative status, comorbidity, and leukocytosis in postoperative complications in the 72 hours after surgery among adults with ruptured cerebral aneurysms at an intensive care unit in tertiary care. The samples in this study were 112 patients. The pathological physiology framework was used. Research instruments included demographic data, history of treatment, Surgical Apgar Score, The Charlson co - morbidity index, and complications in postoperative 72 hours record form with Person separation reliability .80 were collected from the patient’s medical record. Data were analyzed using descriptive statistics and binary logistic regression.


The findings found that patients with moderate to severe comorbidities were 13.73 (OR = 13.73, 95%CI [1.378, 136.698], p-value = .026) times more likely to have complications within 72 hours of surgery than those without comorbidities (χ2 = 6.70, p-value = .01, sensitivity = 2.60%, specificity = 45.90%, positive predictive value = 100%, negative predictive value = 75.60%). These results can be integrated to develop guidelines for screening the risks of postoperative complications. In addition, the management and correction of comorbidities before surgery in patients with ruptured cerebral aneurysms are needed to reduce the incidence of complications after surgery.

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How to Cite
1.
Srinukul A, Danaidutsadeekul S, Chanruangvanich W, Aurboonyawat T. Factors Predicting Postoperative Complication in Patients with Ruptured Cerebral Aneurysms. KJN [Internet]. 2024 Jun. 26 [cited 2024 Dec. 21];31(1):15-29. Available from: https://he01.tci-thaijo.org/index.php/kcn/article/view/267069
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Research Articles

References

Revilla-Pacheco F, Escalante-Seyffert MC, Herrada-Pineda T, Manrique-Guzman S, Perez-Zuniga I, Rangel-Suarez S, et al. Prevalence of incidental clinoid segment saccular aneurysms. World Neurosurgery 2018;115:e244-51. doi: 10.1016/j.wneu.2018.04.027.

Information System Development Group: Department of Medical Services. Mortality of patients with cerebral stroke (Hemorrhagic Stroke: I60-I62) [Internet]. 2024 [cited 4 Feb 2024]. Available from: https://medinfo.dms.go.th/public-health/kpi_reports.php?kpi_year=2566&id=2 (in Thai)

Chung DY, Abdalkader M, Nguyen TN. Aneurysmal subarachnoid hemorrhage. Neurologic Clinics 2021;39(2):419-42. doi: 10.1016/j.ncl.2021.02.006.

Jin J, Duan J, Du L, Xing W, Peng X, Zhao Q. Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): relevant signaling pathways and therapeutic strategies. Frontiers in Immunology 2022;13:1027756. doi: 10.3389/fimmu.2022.1027756.

Pont W, Groeneveld I, Arwert H, Meesters J, Mishre RR, Vlieland TV, et al. Caregiver burden after stroke: changes over time?. Disability and rehabilitation 2020;42(3):360-7. doi: 10.1080/09638288.2018.1499047.

Waiyapat B. Case study: nursing care for patients with cerebral artery aneurysms. Journal of Preventive Medicine Association of Thailand 2016;6(1):71-9. (in Thai)

Dixon KJ. Pathophysiology of traumatic brain injury. Physical Medicine and Rehabilitation Clinics 2017;28(2):215-25. doi: 10.1016/j.pmr.2016.12.001.

Mangat HS. Severe traumatic brain injury. Continuum: Lifelong Learning in Neurology 2012;18(3):532-46. doi: 10.1212/01.CON.0000415426.76524.e1.

Fugate JE. Complications of neurosurgery. Continuum: Lifelong Learning in Neurology 2015;21(5 Neurocritical Care):1425-44. doi: 10.1212/CON.0000000000000227.

Nanda A, Patra DP. Surgical complications in neurosurgery. In: Nanda A, editor. Complications in neurosurgery. London: Elsevier; 2019. p. 17-22.

Narayan V, Kalakoti P, Nanda A. Medical complications in neurosurgery. In: Nanda A, editor. Complications in neurosurgery. London: Elsevier; 2019. p. 13-6.

Kamide T, Burkhardt JK, Tabani H, Safaee M, Lawton MT. Microsurgical clipping techniques and outcomes for paraclinoid internal carotid artery aneurysms. Operative Neurosurgery 2020;18(2):183-92. doi: 10.1093/ons/opz157.

Algattas H, Kimmell KT, Vates GE. Risk of reoperation for hemorrhage in patients after craniotomy. World Neurosurgery 2016;87:531-9. doi: 10.1016/j.wneu.2015.09.020.

Cinotti R, Bruder N, Srairi M, Paugam-Burtz C, Beloeil H, Pottecher J, et al. Prediction score for postoperative neurologic complications after brain tumor craniotomy: a multicenter observational study. Anesthesiology 2018;129(6):1111-20. doi: 10.1097/ALN.0000000000002426.

Lonjaret L, Guyonnet M, Berard E, Vironneau M, Peres F, Sacrista S, et al. Postoperative complications after craniotomy for brain tumor surgery. Anaesthesia, Critical Care and Pain Medicine 2017;36(4):213-8. doi: 10.1016/j.accpm.2016.06.012.

Carli F. Physiologic considerations of enhanced recovery after surgery (ERAS) programs: implications of the stress response. Canadian Journal of Anaesthesia 2015;62(2):110-9. doi: 10.1007/s12630-014-0264-0.

Helander EM, Webb MP, Menard B, Prabhakar A, Helmstetter J, Cornett EM, et al. Metabolic and the surgical stress response considerations to improve postoperative recovery. Current Pain and Headache Reports 2019;23(5):33. doi: 10.1007/s11916-019-0770-4.

Vel R, Udupi BP, Satya Prakash MVS, Adinarayanan S, Mishra S, Babu L. Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients. Saudi Journal of Anaesthesia 2015;9(1):42-8. doi: 10.4103/1658-354X.146304.

Kim Y, Han MH, Kim CH, Kim JM, Cheong JH, Ryu JI. Increased short-term mortality in patients with spontaneous intracerebral hemorrhage and its association with admission glucose levels and leukocytosis. World Neurosurgery 2017;98:503-11. doi: 10.1016/j.wneu.2016.11.087.

Yu Z, Zheng J, Guo R, Ma L, You C, Li H. Prognostic impact of leukocytosis in intracerebral hemorrhage: a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore) 2019;98(28):e16281. doi: 10.1097/MD.0000000000016281.

Tao C, Wang J, Hu X, Ma J, Li H, You C. Clinical value of neutrophil to lymphocyte and platelet to lymphocyte ratio after aneurysmal subarachnoid hemorrhage. Neurocritical Care 2017;26(3):393-401. doi: 10.1007/s12028-016-0332-0.

Ibañez FAL, Hem S, Ajler P, Vecchi E, Ciraolo C, Baccanelli M, et al. A new classification of complications in neurosurgery. World Neurosurgery 2011;75(5-6):709-15. doi: 10.1016/j.wneu.2010.11.010.

Rock AK, Dincer A, Carr MT, Opalak CF, Workman KG, Broaddus WC. Outcomes after craniotomy for resection of craniopharyngiomas in adults: analysis of the National Surgical Quality Improvement Program (NSQIP). Journal of Neuro-Oncology 2019;144(1):117-25. doi: 10.1007/s11060-019-03209-9.

Charlson ME, Charlson RE, Peterson JC, Marinopoulos SS, Briggs WM, Hollenberg JP. The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients. Journal of Clinical Epidemiology 2008;61(12):1234-40. doi: 10.1016/j.jclinepi.2008.01.006.

Gawande AA, Kwaan MR, Regenbogen SE, Lipsitz SA, Zinner MJ. An Apgar score for surgery. Journal of the American College of Surgeons 2007;204(2):201-8. doi: 10.1016/j.jamcollsurg.2006.11.011.

Roffman CE, Buchanan J, Allison GT. Charlson comorbidities index. Journal of Physiotherapy 2016;62(3):171. doi: 10.1016/j.jphys.2016.05.008.

Hsu SY, Ou CY, Ho YN, Huang YH. Application of surgical Apgar score in intracranial meningioma surgery. PLoS One 2017;12(4):e0174328. doi: 10.1371/journal.pone.0174328.

Vecchio TG, Corell A, Buvarp D, Rydén I, Smits A, Jakola AS. Classification of adverse events following surgery in patients with diffuse lower-grade gliomas. Frontiers in Oncology 2021;11:792878. doi: 10.3389/fonc.2021.792878.

Johans SJ, Garst JR, Burkett DJ, Grahnke K, Martin B, Ibrahim TF, et al. Identification of preoperative and intraoperative risk factors for complications in the elderly undergoing elective craniotomy. World Neurosurgery 2017;107:216-25. doi: 10.1016/j.wneu.2017.07.177.

Hsu SY, Huang YH. Characterization and prognostic implications of significant blood loss during intracranial meningioma surgery. Translational Cancer Research 2016;5(6):797-804. doi: 10.21037/tcr.2016.11.72.

Ma X, Lan F, Zhang Y. Associations between C-reactive protein and white blood cell count, occurrence of delayed cerebral ischemia and poor outcome following aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. Acta Neurologica Belgica 2021;121(5):1311-24. doi: 10.1007/s13760-020-01496-y.

Burzynska M, Uryga A, Wozniak J, Załuski R, Robba C, Gozdzik W. The role of early serum biomarkers and clinical rating scales in the prediction of delayed cerebral ischaemia and short-term outcome after aneurysmal subarachnoid haemorrhage: single centre experience. Journal of Clinical Medicine 2023;12(17):5614. doi: 10.3390/jcm12175614.