Epidemiology, clinico-radiological characteristics, and management of cerebral amyloid angiopathy: A literature review
Keywords:
cerebral amyloid angiopathy, beta-amyloid, small vessel disease, imaging biomarkerAbstract
Sporadic cerebral amyloid angiopathy (CAA) is one of the most common cerebral small vessel diseases in the elderly worldwide. Prevalence of CAA depends on the study type, but the prevalence is more common in aging and demented population. Symptomatic CAA patients could present with spontaneous lobar intracerebral hemorrhage (ICH), cognitive decline, and transient focal neurological deficit (or amyloid spell). The current diagnostic criteria are modified Boston’s criteria v 1.5 based on blood sensitive MRI sequences (T2*GRE or SWI). The specific hemorrhagic events comprised of in ICH at cortical-subcortical area, cerebral microbleeds at cortical-subcortical area, and cortical superficial siderosis are the key diagnosis of CAA. The specific treatment has not yet been proved based on current evidence. The high clinical suspicion of CAA and the early diagnosis could lead to proper management, which might prevent further complication and results in the better outcome.
This review article aims to raise the awareness and provide the knowledge of CAA among healthcare providers in aspects of epidemiology, clinico-radiological characteristics and management.
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