Migraine and Stroke
Keywords:
migraine, stroke, migraine without aura, migraine with aura, ischemic stroke, hemorrhagic strokeAbstract
Migraine and stroke may be related. From epidemiological data, patients who had migraine with aura had 2-fold increased risk of ischemic stroke and 1.5 fold increased risk of hemorrhagic stroke. Several hypotheses explained the association between both conditions including polymorphism of many genes, thrombophilia factors, abnormal vascular reactivity, cortical spreading depression and increased risk factors for cardiovascular diseases. Patient with migraine with aura were associated with increased deep white matter hyperintensities and usually had multiple lesions. Differential diagnosis between aura of migraine and transient ischemic attack is difficult in some patients. If the diagnosis is uncertain, physical examination and further investigations are recommended. Aspirin is indicated when thrombosis is found. Management of ischemic stroke patients who also had migraine is the same as other ischemic stroke patients. Migraine without aura patients were not associated with increased risk of stroke or slightly increased, so there is no specific treatment other than acute and preventive treatment for migraine when there is indication. For migraine with aura patients, search for modified cardiovascular risk factors and manage those risks.
References
1. Lipton RB, Bigal ME. The epidemiology of migraine. Am J Med 2005;118 Suppl 1:3S-10S.
2. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 2013;33:629–808.
3. Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, et al. Migraine and cardiovascular disease: a population-based study. Neurology 2010;74:628–35.
4. Buring JE, Hebert P, Romero J, Kittross A, Cook N, MansonJ, et al. Migraine and subsequent risk of stroke in the Physicians’ Health Study. Arch Neurol 1995;52:129–34.
5. Carolei A, Marini C, DeMatteis G. History of migraine and risk of cerebral ischaemia in young adults. The Italian National Research Council Study Group on Stroke in the Young. Lancet 1996;347:1503–6.
6. Chang CL, Donaghy M, Poulter N. Migraine and stroke in young women: case-control study. The World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. BMJ 1999;318:13–8.
7. Donaghy M, Chang CL, Poulter N. On behalf of the European Collaborators of The World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Duration, frequency, recency, and type of migraine and the risk of ischaemic stroke in women of childbearing age. J Neurol Neurosurg Psychiatry
2002;73:747–50.
8. Hall GC, Brown MM, Mo J, MacRae KD. Triptans in migraine : the risks of stroke, cardiovascular disease, and death in practice. Neurology 2004;62:563–8.
9. Henrich JB, Horwitz RI. A controlled study of ischemic stroke risk in migraine patients. J Clin Epidemiol 1989;42:773–80.
10. Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, et al. Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 2005;64:1020–6.
11. MacClellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, et al. Probable migraine with visual aura and risk of ischemic stroke: the Stroke Prevention in Young Women Study. Stroke 2007;38:2438–45.
12. Tzourio C, Iglesias S, Hubert JB, Visy JM, Alpérovitch A, Tehindrazanarivelo A, et al. Migraine and risk of ischaemic stroke: a case-control study. BMJ 1993;307:289–92.
13. Tzourio C, Tehindrazanarivelo A, Iglésias S, Alpérovitch A, Chedru F, d’Anglejan-Chatillon J, et al. Case-control study of migraine and risk of ischaemic stroke in young women. BMJ 1995;310:830–3.
14. Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and metaanalysis of observational studies. BMJ 2005;330:63.
15. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 2009;339:b3914.
16. Spector JT, Kahn SR, Jones MR, Jayakumar M, Dalal D, Nazarian S. Migraine headache and ischemic stroke risk: an updated meta-analysis. Am J Med 2010;123:612–24.
17. Kurth T, Schürks M, Logroscino G, Buring JE. Migraine frequency and risk of cardiovascular disease in women. Neurology 2009;73:581–8.
18. Kurth T, Schürks M, Logroscino G, Gaziano JM, Buring JE. Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ 2008;337:a636.
19. KurthT, Kase CS, Schürks M, Tzourio C, Buring JE. Migraine and risk of haemorragic stroke in women:
prospective cohort study. BMJ 2010;341:c3659.
20. Rist PM, Buring JE, Kase CS, Schürks M, Kurth T. Migraine and functional outcome from ischemic cerebral events in women. Circulation 2010;122:2551–7.
21. Gudmundsson LS, Scher AI, Aspelund T, Eliasson JH, Johannsson M, Thorgeirsson G, et al. Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study. BMJ 2010;341:c3966.
22. Kurth T, Winter AC, Eliassen AH, Dushkes R, Kenneth J Mukamal KJ, et al. Migraine and risk of cardiovascular disease in women: prospective cohort study. BMJ 2016;353:i2610.
23. Kristensen B, Malm J, Carlberg B, Stegmayr B, Backman C, Fagerlund M, et al. Epidemiology and etiology of ischemic stroke in young adults aged 18 to 44 years in Northern Sweden. Stroke 1997;28:1702–9.
24. Kittner SJ, Stern BJ, Wozniak M, Buchholz DW, Earley CJ, Feeser BR, et al. Cerebral infarction in
young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology 1998;50:890–4.
25. Adams Jr HP, Kappelle LJ, Biller J, Gordon DL, Love BB, Gomez F, et al. Ischemic stroke in young adults.
Experience in 329 patients enrolled in the Iowa Registry of Stroke in young adults. Arch Neurol 1995;52:491–5.
26. Rasura M, Spalloni A, Ferrari M, De Castro S, Patella R, Lisi F, et al. A case series of young stroke in Rome. Eur J Neurol 2006;13:146–52.
27. Putaala J, Metso AJ, Metso TM, Konkola N, Kraemer Y, Haapaniemi E, et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki Young Stroke Registry. Stroke 2009;40:1195–203.
28. Petitti DB, Sidney S, Quesenberry CP, Allan Bernstein. Incidence of stroke and myocardial infarction in women of reproductive age. Stroke 1997;28:280-83.
29. Evans W, Becker MD. Migraine and oral contraceptives. Headache 2006;46:328-31.
30. Bushnell CD, Jamison M, James AH. Migraines during pregnancy linked to stroke and vascular diseases: US population based case-control study. BMJ 2009;338:b664.
31. Vestergaard K, Andersen G, Nielsen M, Jensen T. Headache in stroke. Stroke 1993;24:1621-4.
32. Gorelick P, Hier D, Caplan L, Langenberg P. Headache in acute cerebrovascular disease. Neurology 1986;36:1445-50.
33. Sochurkova D, Moreau T, Lemesle M, Menassa M, Giroud M, Dumas R. Migraine history and migraine-induced stroke in the Dijon Stroke Registry. Neuroepidemiology 1999;18:85–91.
34. Arboix A, Massons J, Garcia-Eroles L, Oliveres M, Balcells M, Targa C. Migrainous cerebral infarction in the sagrat cor hospital of Barcelona Stroke Registry. Cephalalgia Int J Headache 2003;23:389–94.
35. Laurell K, Artto V, Bendtsen L, Hagen K, Kallela M, Meyer EL, et al. Migrainous infarction: a Nordic Multicenter Study. Eur J Neurol 2011;18:1220–6.
36. Marshall N, Maclaurin WA, Koulouris G. MRA captures vasospasm in fatal migrainous infarction. Headache 2007;47:280–3.
37. Pezzini A, Grassi M, Lodigiani C, Patella R, Gandolfo C, Zini A, et al. on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators. Predictors of long-term recurrent vascular events after ischemic stroke at young age:
the Italian Project on Stroke in Young Adults. Circulation 2014;129:1668-1676.
38. Gioia LC, Tollard E, Dubuc V, Lanthier S, Deschaintre Y, Chagnon M, et al. Silent ischemic lesions in young adults with first stroke are associated with recurrent stroke. Neurology 2012;79:1208-1214.
39. Kuo CY, Yen MF, Chen LS, Fann CY, Chiu YH, Chen HH, et al. Increased risk of hemorrhagic stroke in patients with migraine: a population-based cohort study. PLoS One 2013; 8:e55253.
40. Sacco S, Ornello R, Ripa P, Pistoia F, Carolei A. Migraine and Hemorrhagic Stroke : A Meta-analysis. Stroke 2013;44:3032-8.
41. Carter KN, Anderson N, Jamrozik K, Hankey G, Anderson CS; Australasian Co-operative Research on Subarachnoid Haemorrhage Study (ACROSS) Group. Migraine and risk of subarachnoid haemorrhage:a population-based case-control study. J Clin Neurosci 2005;12:534–7.
42. Schurks M, Buring JE, Kurth T. Migraine features, associated symptoms and triggers: a principal component analysis in the Women’s Health Study. Cephalalgia 2011;31:861–9.
43. Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS, et al. Genomewide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet 2010;42:869–73.
44. Chasman DI, Schurks M, Anttila V, de Vries B, Schminke U, Launer LJ, et al. Genome- wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet 2011;43:695–8.
45. Kowa H, Yasui K, Takeshima T, Urakami K, Sakai F, Nakashima K. The homozygous C677T mutation in the methylentetrahydrofolate reductase gene is a genetic risk factor for migraine. Am J Med Genet (Neuropsychiatr Genet) 2000;96:762–4.
46. Kara I, Sazci A, Ergul E, Kaya G, Kilic G. Association of the C677T and A1298C polymorphism in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Mol Brain Res 2003;111:84–90.
47. Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H, et al. Migraine and MTHFR C677T
genotype in a population-based sample. Ann Neurol 2006;59:372–5.
48. Oterino A, Valle N, Bravo Y, Munoz P, Sanchez-Velasco P, Ruiz-Alegria C, et al. MTHFR T677 homozygosis influences the presence of aura in migraineurs. Cephalalgia 2004;24:491–4.
49. Pezzini A, Grassi M, Del Zotto E, Giossi A, Monastero R, Dalla Volta G, et al. Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke- subtype effect. Stroke 2007;38:3145–51.
50. Schurks M, Zee RY, Buring JE, Kurth T. Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease. Neurology 2008;71:505–13.
51. Hassan A, Hunt BJ, O’Sullivan M, Bell R, D’Souza R, Jeffery S, et al. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain 2004;127:212-9.
52. Tietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009;40:2977–82.
53. Kurth T, Ridker PM, Buring JE. Migraine and biomarkers of cardiovascular disease in women. Cephalalgia 2008;28:49–56.
54. Schürks M, Zee RY, Buring JE, Kurth T. ACE D/I polymorphism, migraine, and cardiovascular disease in women. Neurology 2009;72:650–6.
55. Schürks M, Kurth T, Ridker PM, Buring JE, Zee RY. Association between polymorphisms in the β2- adrenoceptor gene and migraine in women. Headache 2009;49:235–44.
56. Schürks M, Rist PM, Kurth T. MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis. Headache 2010;50:588–99.
57. Schürks M, Buring JE, Ridker PM, Chasman DI, Kurth T. Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study. PLoS One 2011;6:e22106.
58. Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 1996;87:543–52.
59. Dichgans M, Freilinger T, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 2005;366:371–7.
60. De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L, et al. Haploinsuffi ciency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 2003;33:192–6.
61. D’Andrea G, Hasselmark L, Alecci M, Cananzi A, Perini F, Welch KM. Platelet secretion from dense and alpha-granules in vitro in migraine with or without aura. J Neurol Neurosurg Psychiatry 1994;57:557–61.
62. Zeller JA, Frahm K, Baron R, Stingele R, Deuschl G. Platelet-leukocyte interaction and platelet activation in migraine: a link to ischemic stroke? J Neurol Neurosurg Psychiatry 2004;75:984–7.
63. Gallai V, Sarchielli P, Firenze C, Trequattrini A, Paciaroni M, Usai F, et al. Endothelin 1 in migraine and tension-type headache. Acta Neurol Scand 1994;89:47–55.
64. Tietjen GE, Al-Qasmi MM, Athanas K, Dafer RM, Khuder SA. Increased von Willebrand factor in migraine. Neurology 2001;57:334–6.
65. Hering-Hanit R, Friedman Z, Schlesinger I, Ellis M. Evidence for activation of the coagulation system in migraine with aura. Cephalalgia 2001;21:137–9.
66. Tanasescu R, Nicolau A, Caraiola S, Ticmeanu M, Cojocaru IM, Frăsineanu A, et al. Antiphospholipid antibodies and migraine: a retrospective study of 428 patients with inflammatory connective tissue diseases. Rom J Intern Med 2007;45:355–63.
67. Crassard I, Conard J, Bousser MG. Migraine and hemostasis. Cephalalgia 2001;21:630–6.
68. Robbins L. Migraine and anticardiolipin antibodies –case reports of 13 patients and the prevalence of antiphospholipid antibodies in migraineurs. Headache 1991;31:537–9.
69. Kontula K, Ylikorkala A, Miettinen H, Vuorio A, Kauppinen-Makelin R, Hamalainen L. Arg506Gln factor V mutation (factor V Leiden) in patients with ischemic cerebrovascular disease and survivors of myocardial infarction. Thromb Haemost 1995;73:558–80.
70. D’Amico D, Moschiano F, Leone M, Ariano C, Ciusani E, Erba N, et al. Genetic abnormalities of the protein C system: shared risk factors in young adults with migraine with aura and with ischemic stroke? Cephalalgia 1998;18:618–21.
71. Corral J, Iniesta JA, Gonzales-Conejero R, Lozano ML, Rivera J, Vicente V. Migraine and prothrombotic genetic risk factors. Cephalalgia 1998;18:257–60.
72. Soriani S, Borgna-Pignatti C, Trabetti E, Casartelli A, Montagna P, Pignati PF. Frequency of Factor V Leiden in juvenile migraine with aura. Headache 1998;38:779–81.
73. Haan J, Kapelle LJ, de Ronde H, Ferrari MD, Bertina RM. The factor V Leiden is not a major risk factor for migrainous cerebral infarction. Cephalalgia 1997;17:605–7.
74. D’Amico D, Rigamonti A, Corsini E, Parati EA, Bussone G. Activation of the coagulation system in migraine patients. Cephalalgia 2003;23:750–1.
75. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke. JAMA 2002;288:2012–22.
76. Hering-Hanit R, Gadoth N, Yavetz A, Gavendo S, Sela B. Is blood homocysteine elevated in migraine? Headache 2001;41:779–81.
77. D’Amico D, Moschiano F, Attanasio A, Erba N, Ciusani E, Schieroni F. Hyperhomocysteinemia in patients with migraine with aura. Cephalalgia 2003;23:742.
78. Moschiano F, D’Amico D, Ciusani E, Erba N, Rigamonti A, Schieroni F, et al. Coagulation abnormalities in migraine and ischaemic cerebrovascular disease: a link between migraine and ischaemic stroke? Neurol Sci 2004; 25:S126–8.
79. Vanmolkot FH, Van Bortel LM, de Hoon JN. Altered arterial function in migraine of recent onset. Neurology 2007;68:1563-70.
80. Napoli R, Guardasole V, Zarra E, Matarazzo M, D’Anna C, Saccà F, et al. Vascular smooth muscle cell dysfunction in patients with migraine. Neurology 2009;72:2111-4.
81. Tietjen GE. Migraine as a systemic vasculopathy. Cephalalgia 2009;29:987-96.
82. Lee ST, Chu K, Jung KH, Kim DH, Kim EH, Choe VN, et al. Decreased number and function of endothelial progenitor cells in patients with migraine. Neurology 2008;70:1510-7.
83. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348: 593-600.
84. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005;353:999-1007.
85. Kunz GA, Liang G, Cuculi F, Gregg D, Vata KC, Shaw LK, et al. Circulating endothelial progenitor cells predict coronary artery disease severity. Am Heart J 2006;152:190–5.
86. Diener HC, Kurth T, Dodick D. Patent foramen ovale, stroke, and cardiovascular disease in migraine. Curr Opin Neurol 2007;20:310–9.
87. Rundek T, Elkind MS, Di Tullio MR, Carrera E, Jin Z, Sacco RL, et al. Patent foramen ovale and migraine: a cross- sectional study from the Northern Manhattan Study (NOMAS). Circulation 2008;118:1419–24.
88. Garg P, Servoss SJ, Wu JC, Bajwa ZH, Selim MH, Dineen A, et al. Lack of association between migraine headache and patent foramen ovale: results of a case–control study. Circulation 2010;121:1406–12.
89. Woods TD, Harmann L, Purath T, Ramamurthy S, Subramanian S, Jackson S. Small- and moderate- size right-to-left shunts identified by saline contrast echocardiography are normal and unrelated to migraine headache. Chest 2010;138:264–9.
90. Feurer R, Sadikovic S, Sepp D, Esposito L, Schleef M, Bockelbrink A, et al. Patent foramen ovale is not associated with an increased risk of stroke recurrence. Eur J Neurol 2010;17:1339–45.
91. Nozari A, Dilekoz E, Sukhotinsky I, Stein T, Eikermann- Haerter K, Liu C, et al. Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol 2010;67:221–9.
92. Dreier JP. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 2011;17:439–47.
93. Thaler DE, Saver JL. Cryptogenic stroke and patent foramen ovale. Curr Opin Cardiol 2008;23:537–44.
94. Goadsby PJ. Current concepts of the pathophysiology of migraine. Neurol Clin 1997;15:27–42.
95. Moskowitz MA. Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment. Funct Neurol 2007;22:133–6.
96. Moskowitz MA, Kurth T. Blood vessels, migraine, and stroke. Stroke 2007;38:3117–8.
97. Lauritzen M, Dreier JP, Fabricius M, Hartings JA, Graf R, Strong AJ. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab 2011;31:17–35.
98. Gursoy-Ozdemir Y, Qiu J, Matsuoka N, Bolay H, Bermpohl D, Jin H, et al. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest 2004;113:1447–55.
99. Imamura K, Takeshima T, Fusayasu E, Nakashima K. Increased plasma matrix metalloproteinase-9 levels in migraineurs. Headache 2008;48:135–9.
100. Lauritzen M, Skyhoj Olsen T, Lassen NA, Paulson OB. Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol 1983;13:633–41.
101. Welch KM, Brandes AW, Salerno L, Brandes JL. C- reactive protein may be increased in migraine patients who present with complex clinical features. Headache 2006;46:197–9.
102. Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ. Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 2005;64:614–20.
103. Scher AI, Stewart WF, Ricci JA, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 2003;106:81–9.
104. Bigal ME, Lipton RB. Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology 2006;67:252–7.
105. Bigal ME, Liberman JN, Lipton RB. Obesity and migraine:a population study. Neurology 2006;66:545–50.
106. Bigal ME, Kurth T, Hu H, Santanello N, Lipton RB. Migraine and cardiovascular disease. Possible mechanisms of interaction. Neurology 2009;72:1864–71.
107. Cavestro C, Rosatello A, Micca G, Ravotto M, Marino MP, Asteggiano G, et al. Insulin metabolism is altered in migraineurs: a new pathogenic mechanism for migraine? Headache 2007;47:1436–42.
108. Rist PM, Diener HC, Kurth T, Schurks M. Migraine, migraine aura, and cervical artery dissection: a systematic review and meta-analysis. Cephalalgia 2011;31:886-96.
109. Debette S, Markus HS. The genetics of cervical artery dissection: a systematic review. Stroke 2009;40:e459-66.
110. Tzourio C, El Amrani M, Robert L, Alperovitch A. Serum elastase activity is elevated in migraine. Ann Neurol 2000;47:648-51.
111. Asghar MS, Hansen AE, Amin FM, van der Geest RJ, Koning Pv, Larsson HB, et al. Evidence for a vascular factor in migraine. Ann Neurol 2011; 69: 635–45.
112. Borgdorff P, Tangelder GJ. Migraine: possible role of shear-induced platelet aggregation with serotonin
release. Headache 2012;52:1298–318.
113. Sacco S, Olivieri L, Bastianello S, Carolei A. Comorbid neuropathologies in migraine. J Headache Pain 2006;7:222–30.
114. Sacco S, Cerone D, Carolei A. Comorbid neuropathologies in migraine:an update on cerebrovascular and cardiovascular aspects. J Headache Pain 2008;9:237–48.
115. Heckmann JG, Hilz MJ, Katalinic A, Marthol H, Muck-Weymann M, B Neundörfer. Myogenic cerebrovascular autoregulation in migraine measured by stress transcranial Doppler sonography. Cephalalgia 1998;18:133–7.
116. Smeda JS. Cerebral vascular changes associated with hemorrhagic stroke in hypertension. Can J Physiol Pharmacol 1992;70:552–64.
117. Daneshtalab N, Smeda JS. Alterations in the modulation of cerebrovascular tone and blood flow by nitric oxide synthases in SHRsp with stroke. Cardiovasc Res 2010;86:160–8.
118. Swartz RH, Kern RZ. Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol 2004;61:1366–8.
119. Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, et al. Migraine as a risk factor for subclinical brain lesions. JAMA 2004;291:427–34.
120. Scher AI, Gudmundsson LS, Sigurdsson S, Ghambaryan A, Aspelund T, Eiriksdottir G, et al. Migraine headache in middle age and late- life brain infarcts. JAMA 2009;301:2563–70.
121. Kurth T, Mohamed S, Maillard P, Zhu YC, Chabriat H, Mazoyer B, et al. Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing- MRI study. BMJ 2011;342:c7357.
122. Kruit MC, Launer LJ, Ferrari M, van Buchem MA. Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study. Brain 2005;128:2068-77.
123. Caplan LR, Hennerici M. Impaired clearance of emboli(washout) is an important link between hypoperfusion, embolism, and ischemic stroke. Arch Neurol 1998;55:1475-82.
124. Reinhard M, Schork J, Allignol A, Weiller C, Kaube H. Cerebellar and cerebral autoregulation in migraine. Stroke 2012;43:987-93.
125. Bashir A, Lipton RB, Ashina S, Ashina M. Migraine and structural changes in the brain: A systematic review and meta-analysis. Neurology 2013;81:1260-8.
126. Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, Konishi J, Moonen JM, et al. Structural brain
changes in migraine. JAMA 2012;308:1889-97.
127. Wijman CA, Wolf PA, Kase CS, Kelly- Hayes M, Beiser AS. Migrainous visual accompaniments are not rare in late life: the Framingham Study. Stroke 1998;29:1539–43.
128. Olesen J, Friberg L, Olsen TS, Andersen AR, Lassen NA, Hansen PE, et al. Ischaemia-induced (symptomatic) migraine attacks may be more frequent than migraine-induced ischaemic insults. Brain 1993;116:187– 202.
129. Angus-Leppan H. Migraine: mimics, borderlands and chameleons. Pract Neurol 2013;13:308–18.
130. Ducros A, Boukobza M, Porcher R, Sarov M, Valade D, Bousser MG. The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain 2007;130:3091–101.
131. Call GK, Fleming MC, Sealfon S, Levine H, Kistler JP, Fisher CM. Reversible cerebral segmental vasoconstriction. Stroke 1988;19:1159–70.
132. Bousser MG, Welch KM. Relation between migraine and stroke. Lancet Neurol 2005;4: 533–42. 133. Fisher CM. Late-life migraine accompaniments as a cause of unexplained transient ischemic attacks. Can J Neurol Sci 1980;7:9–17.
134. Izenberg A, Aviv RI, Demaerschalk BM, Dodick DW, Hopyan J, Black SE, et al. Crescendo transient aura attacks: a transient ischemic attack mimic caused by focal subarachnoid hemorrhage. Stroke 2009;40:3725–29.
135. Kurth T, Diener HC, Buring JE. Migraine and cardiovascular disease in women and the role of aspirin: subgroup analyses in the Women’s Health Study. Cephalalgia 2011;31:1106–15.
136. Halkes PH, van Gijn J, Kappelle LJ, Koudstaal PJ, Algra A. Risk indica tors for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin. J Neurol Neurosurg Psychiatry 2009;80:437–9.
137. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321–33.
138. Detsky ME, McDonald DR, Baerlocher MO, Tomlinson GA, McCrory DC, Booth CM. Does this patient with headache have a migraine or need neuroimaging? JAMA 2006;296:1274–83.
139. Zhu YC, Dufouil C, Tzourio C, Chabriat H. Silent brain infarcts: a review of MRI diagnostic criteria. Stroke 2011;42:1140–5.
140. Hedman C, Andersen AR, Andersson PG, Gilhus NE, Kangasniemi P, Olsson JE, et al. Symptoms of classic migraine attacks: modifications brought about by metoprolol. Cephalalgia 1988;8:279–84.
141. Hall GC, Brown MM, Mo J, MacRae KD. Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice. Neurology 2004;62:563-8.
142. Wammes-van der Heijden EA, Rahimtoola H, Leufkens HG, Tijssen CC, Egberts AC. Risk of ischemic complications related to the intensity of triptan and ergotamine use. Neurology 2006;67:1128-34.
143. Allais G, Gabellari IC, De Lorenzo C, Mana O, Benedetto C. Oral contraceptive in migraine. Expert Rev Neurother 2009;9:381-93.
144. Edlow AG, Bartz D. Hormonal contraceptive options for women with headache: A review of the evidence. Rev Obstet Gynecol 2010;3:55-65.
145. Lampl C, Katsarava Z, Diener HC, Limmroth V. Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura. J Neurol Neurosurg Psychiatry 2005;76:1730–2.
146. Rothrock J, North J, Madden K, Lyden P, Fleck P, Dittrich H. Migraine and migrainous stroke: risk factors and prognosis. Neurology 1993;43:2473–6.
147. Laurell K, Lundström E. Migrainous Infarction: Aspects on Risk Factors and Therapy. Curr Pain Headache Rep 2012;16:255–60.
2. Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 2013;33:629–808.
3. Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, et al. Migraine and cardiovascular disease: a population-based study. Neurology 2010;74:628–35.
4. Buring JE, Hebert P, Romero J, Kittross A, Cook N, MansonJ, et al. Migraine and subsequent risk of stroke in the Physicians’ Health Study. Arch Neurol 1995;52:129–34.
5. Carolei A, Marini C, DeMatteis G. History of migraine and risk of cerebral ischaemia in young adults. The Italian National Research Council Study Group on Stroke in the Young. Lancet 1996;347:1503–6.
6. Chang CL, Donaghy M, Poulter N. Migraine and stroke in young women: case-control study. The World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. BMJ 1999;318:13–8.
7. Donaghy M, Chang CL, Poulter N. On behalf of the European Collaborators of The World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception. Duration, frequency, recency, and type of migraine and the risk of ischaemic stroke in women of childbearing age. J Neurol Neurosurg Psychiatry
2002;73:747–50.
8. Hall GC, Brown MM, Mo J, MacRae KD. Triptans in migraine : the risks of stroke, cardiovascular disease, and death in practice. Neurology 2004;62:563–8.
9. Henrich JB, Horwitz RI. A controlled study of ischemic stroke risk in migraine patients. J Clin Epidemiol 1989;42:773–80.
10. Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, et al. Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 2005;64:1020–6.
11. MacClellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, et al. Probable migraine with visual aura and risk of ischemic stroke: the Stroke Prevention in Young Women Study. Stroke 2007;38:2438–45.
12. Tzourio C, Iglesias S, Hubert JB, Visy JM, Alpérovitch A, Tehindrazanarivelo A, et al. Migraine and risk of ischaemic stroke: a case-control study. BMJ 1993;307:289–92.
13. Tzourio C, Tehindrazanarivelo A, Iglésias S, Alpérovitch A, Chedru F, d’Anglejan-Chatillon J, et al. Case-control study of migraine and risk of ischaemic stroke in young women. BMJ 1995;310:830–3.
14. Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and metaanalysis of observational studies. BMJ 2005;330:63.
15. Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ 2009;339:b3914.
16. Spector JT, Kahn SR, Jones MR, Jayakumar M, Dalal D, Nazarian S. Migraine headache and ischemic stroke risk: an updated meta-analysis. Am J Med 2010;123:612–24.
17. Kurth T, Schürks M, Logroscino G, Buring JE. Migraine frequency and risk of cardiovascular disease in women. Neurology 2009;73:581–8.
18. Kurth T, Schürks M, Logroscino G, Gaziano JM, Buring JE. Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ 2008;337:a636.
19. KurthT, Kase CS, Schürks M, Tzourio C, Buring JE. Migraine and risk of haemorragic stroke in women:
prospective cohort study. BMJ 2010;341:c3659.
20. Rist PM, Buring JE, Kase CS, Schürks M, Kurth T. Migraine and functional outcome from ischemic cerebral events in women. Circulation 2010;122:2551–7.
21. Gudmundsson LS, Scher AI, Aspelund T, Eliasson JH, Johannsson M, Thorgeirsson G, et al. Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study. BMJ 2010;341:c3966.
22. Kurth T, Winter AC, Eliassen AH, Dushkes R, Kenneth J Mukamal KJ, et al. Migraine and risk of cardiovascular disease in women: prospective cohort study. BMJ 2016;353:i2610.
23. Kristensen B, Malm J, Carlberg B, Stegmayr B, Backman C, Fagerlund M, et al. Epidemiology and etiology of ischemic stroke in young adults aged 18 to 44 years in Northern Sweden. Stroke 1997;28:1702–9.
24. Kittner SJ, Stern BJ, Wozniak M, Buchholz DW, Earley CJ, Feeser BR, et al. Cerebral infarction in
young adults: the Baltimore-Washington Cooperative Young Stroke Study. Neurology 1998;50:890–4.
25. Adams Jr HP, Kappelle LJ, Biller J, Gordon DL, Love BB, Gomez F, et al. Ischemic stroke in young adults.
Experience in 329 patients enrolled in the Iowa Registry of Stroke in young adults. Arch Neurol 1995;52:491–5.
26. Rasura M, Spalloni A, Ferrari M, De Castro S, Patella R, Lisi F, et al. A case series of young stroke in Rome. Eur J Neurol 2006;13:146–52.
27. Putaala J, Metso AJ, Metso TM, Konkola N, Kraemer Y, Haapaniemi E, et al. Analysis of 1008 consecutive patients aged 15 to 49 with first-ever ischemic stroke: the Helsinki Young Stroke Registry. Stroke 2009;40:1195–203.
28. Petitti DB, Sidney S, Quesenberry CP, Allan Bernstein. Incidence of stroke and myocardial infarction in women of reproductive age. Stroke 1997;28:280-83.
29. Evans W, Becker MD. Migraine and oral contraceptives. Headache 2006;46:328-31.
30. Bushnell CD, Jamison M, James AH. Migraines during pregnancy linked to stroke and vascular diseases: US population based case-control study. BMJ 2009;338:b664.
31. Vestergaard K, Andersen G, Nielsen M, Jensen T. Headache in stroke. Stroke 1993;24:1621-4.
32. Gorelick P, Hier D, Caplan L, Langenberg P. Headache in acute cerebrovascular disease. Neurology 1986;36:1445-50.
33. Sochurkova D, Moreau T, Lemesle M, Menassa M, Giroud M, Dumas R. Migraine history and migraine-induced stroke in the Dijon Stroke Registry. Neuroepidemiology 1999;18:85–91.
34. Arboix A, Massons J, Garcia-Eroles L, Oliveres M, Balcells M, Targa C. Migrainous cerebral infarction in the sagrat cor hospital of Barcelona Stroke Registry. Cephalalgia Int J Headache 2003;23:389–94.
35. Laurell K, Artto V, Bendtsen L, Hagen K, Kallela M, Meyer EL, et al. Migrainous infarction: a Nordic Multicenter Study. Eur J Neurol 2011;18:1220–6.
36. Marshall N, Maclaurin WA, Koulouris G. MRA captures vasospasm in fatal migrainous infarction. Headache 2007;47:280–3.
37. Pezzini A, Grassi M, Lodigiani C, Patella R, Gandolfo C, Zini A, et al. on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators. Predictors of long-term recurrent vascular events after ischemic stroke at young age:
the Italian Project on Stroke in Young Adults. Circulation 2014;129:1668-1676.
38. Gioia LC, Tollard E, Dubuc V, Lanthier S, Deschaintre Y, Chagnon M, et al. Silent ischemic lesions in young adults with first stroke are associated with recurrent stroke. Neurology 2012;79:1208-1214.
39. Kuo CY, Yen MF, Chen LS, Fann CY, Chiu YH, Chen HH, et al. Increased risk of hemorrhagic stroke in patients with migraine: a population-based cohort study. PLoS One 2013; 8:e55253.
40. Sacco S, Ornello R, Ripa P, Pistoia F, Carolei A. Migraine and Hemorrhagic Stroke : A Meta-analysis. Stroke 2013;44:3032-8.
41. Carter KN, Anderson N, Jamrozik K, Hankey G, Anderson CS; Australasian Co-operative Research on Subarachnoid Haemorrhage Study (ACROSS) Group. Migraine and risk of subarachnoid haemorrhage:a population-based case-control study. J Clin Neurosci 2005;12:534–7.
42. Schurks M, Buring JE, Kurth T. Migraine features, associated symptoms and triggers: a principal component analysis in the Women’s Health Study. Cephalalgia 2011;31:861–9.
43. Anttila V, Stefansson H, Kallela M, Todt U, Terwindt GM, Calafato MS, et al. Genomewide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet 2010;42:869–73.
44. Chasman DI, Schurks M, Anttila V, de Vries B, Schminke U, Launer LJ, et al. Genome- wide association study reveals three susceptibility loci for common migraine in the general population. Nat Genet 2011;43:695–8.
45. Kowa H, Yasui K, Takeshima T, Urakami K, Sakai F, Nakashima K. The homozygous C677T mutation in the methylentetrahydrofolate reductase gene is a genetic risk factor for migraine. Am J Med Genet (Neuropsychiatr Genet) 2000;96:762–4.
46. Kara I, Sazci A, Ergul E, Kaya G, Kilic G. Association of the C677T and A1298C polymorphism in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Mol Brain Res 2003;111:84–90.
47. Scher AI, Terwindt GM, Verschuren WM, Kruit MC, Blom HJ, Kowa H, et al. Migraine and MTHFR C677T
genotype in a population-based sample. Ann Neurol 2006;59:372–5.
48. Oterino A, Valle N, Bravo Y, Munoz P, Sanchez-Velasco P, Ruiz-Alegria C, et al. MTHFR T677 homozygosis influences the presence of aura in migraineurs. Cephalalgia 2004;24:491–4.
49. Pezzini A, Grassi M, Del Zotto E, Giossi A, Monastero R, Dalla Volta G, et al. Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke- subtype effect. Stroke 2007;38:3145–51.
50. Schurks M, Zee RY, Buring JE, Kurth T. Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease. Neurology 2008;71:505–13.
51. Hassan A, Hunt BJ, O’Sullivan M, Bell R, D’Souza R, Jeffery S, et al. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain 2004;127:212-9.
52. Tietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA. Migraine and biomarkers of endothelial activation in young women. Stroke 2009;40:2977–82.
53. Kurth T, Ridker PM, Buring JE. Migraine and biomarkers of cardiovascular disease in women. Cephalalgia 2008;28:49–56.
54. Schürks M, Zee RY, Buring JE, Kurth T. ACE D/I polymorphism, migraine, and cardiovascular disease in women. Neurology 2009;72:650–6.
55. Schürks M, Kurth T, Ridker PM, Buring JE, Zee RY. Association between polymorphisms in the β2- adrenoceptor gene and migraine in women. Headache 2009;49:235–44.
56. Schürks M, Rist PM, Kurth T. MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis. Headache 2010;50:588–99.
57. Schürks M, Buring JE, Ridker PM, Chasman DI, Kurth T. Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study. PLoS One 2011;6:e22106.
58. Ophoff RA, Terwindt GM, Vergouwe MN, van Eijk R, Oefner PJ, Hoffman SM, et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell 1996;87:543–52.
59. Dichgans M, Freilinger T, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 2005;366:371–7.
60. De Fusco M, Marconi R, Silvestri L, Atorino L, Rampoldi L, Morgante L, et al. Haploinsuffi ciency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nat Genet 2003;33:192–6.
61. D’Andrea G, Hasselmark L, Alecci M, Cananzi A, Perini F, Welch KM. Platelet secretion from dense and alpha-granules in vitro in migraine with or without aura. J Neurol Neurosurg Psychiatry 1994;57:557–61.
62. Zeller JA, Frahm K, Baron R, Stingele R, Deuschl G. Platelet-leukocyte interaction and platelet activation in migraine: a link to ischemic stroke? J Neurol Neurosurg Psychiatry 2004;75:984–7.
63. Gallai V, Sarchielli P, Firenze C, Trequattrini A, Paciaroni M, Usai F, et al. Endothelin 1 in migraine and tension-type headache. Acta Neurol Scand 1994;89:47–55.
64. Tietjen GE, Al-Qasmi MM, Athanas K, Dafer RM, Khuder SA. Increased von Willebrand factor in migraine. Neurology 2001;57:334–6.
65. Hering-Hanit R, Friedman Z, Schlesinger I, Ellis M. Evidence for activation of the coagulation system in migraine with aura. Cephalalgia 2001;21:137–9.
66. Tanasescu R, Nicolau A, Caraiola S, Ticmeanu M, Cojocaru IM, Frăsineanu A, et al. Antiphospholipid antibodies and migraine: a retrospective study of 428 patients with inflammatory connective tissue diseases. Rom J Intern Med 2007;45:355–63.
67. Crassard I, Conard J, Bousser MG. Migraine and hemostasis. Cephalalgia 2001;21:630–6.
68. Robbins L. Migraine and anticardiolipin antibodies –case reports of 13 patients and the prevalence of antiphospholipid antibodies in migraineurs. Headache 1991;31:537–9.
69. Kontula K, Ylikorkala A, Miettinen H, Vuorio A, Kauppinen-Makelin R, Hamalainen L. Arg506Gln factor V mutation (factor V Leiden) in patients with ischemic cerebrovascular disease and survivors of myocardial infarction. Thromb Haemost 1995;73:558–80.
70. D’Amico D, Moschiano F, Leone M, Ariano C, Ciusani E, Erba N, et al. Genetic abnormalities of the protein C system: shared risk factors in young adults with migraine with aura and with ischemic stroke? Cephalalgia 1998;18:618–21.
71. Corral J, Iniesta JA, Gonzales-Conejero R, Lozano ML, Rivera J, Vicente V. Migraine and prothrombotic genetic risk factors. Cephalalgia 1998;18:257–60.
72. Soriani S, Borgna-Pignatti C, Trabetti E, Casartelli A, Montagna P, Pignati PF. Frequency of Factor V Leiden in juvenile migraine with aura. Headache 1998;38:779–81.
73. Haan J, Kapelle LJ, de Ronde H, Ferrari MD, Bertina RM. The factor V Leiden is not a major risk factor for migrainous cerebral infarction. Cephalalgia 1997;17:605–7.
74. D’Amico D, Rigamonti A, Corsini E, Parati EA, Bussone G. Activation of the coagulation system in migraine patients. Cephalalgia 2003;23:750–1.
75. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke. JAMA 2002;288:2012–22.
76. Hering-Hanit R, Gadoth N, Yavetz A, Gavendo S, Sela B. Is blood homocysteine elevated in migraine? Headache 2001;41:779–81.
77. D’Amico D, Moschiano F, Attanasio A, Erba N, Ciusani E, Schieroni F. Hyperhomocysteinemia in patients with migraine with aura. Cephalalgia 2003;23:742.
78. Moschiano F, D’Amico D, Ciusani E, Erba N, Rigamonti A, Schieroni F, et al. Coagulation abnormalities in migraine and ischaemic cerebrovascular disease: a link between migraine and ischaemic stroke? Neurol Sci 2004; 25:S126–8.
79. Vanmolkot FH, Van Bortel LM, de Hoon JN. Altered arterial function in migraine of recent onset. Neurology 2007;68:1563-70.
80. Napoli R, Guardasole V, Zarra E, Matarazzo M, D’Anna C, Saccà F, et al. Vascular smooth muscle cell dysfunction in patients with migraine. Neurology 2009;72:2111-4.
81. Tietjen GE. Migraine as a systemic vasculopathy. Cephalalgia 2009;29:987-96.
82. Lee ST, Chu K, Jung KH, Kim DH, Kim EH, Choe VN, et al. Decreased number and function of endothelial progenitor cells in patients with migraine. Neurology 2008;70:1510-7.
83. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348: 593-600.
84. Werner N, Kosiol S, Schiegl T, Ahlers P, Walenta K, Link A, et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005;353:999-1007.
85. Kunz GA, Liang G, Cuculi F, Gregg D, Vata KC, Shaw LK, et al. Circulating endothelial progenitor cells predict coronary artery disease severity. Am Heart J 2006;152:190–5.
86. Diener HC, Kurth T, Dodick D. Patent foramen ovale, stroke, and cardiovascular disease in migraine. Curr Opin Neurol 2007;20:310–9.
87. Rundek T, Elkind MS, Di Tullio MR, Carrera E, Jin Z, Sacco RL, et al. Patent foramen ovale and migraine: a cross- sectional study from the Northern Manhattan Study (NOMAS). Circulation 2008;118:1419–24.
88. Garg P, Servoss SJ, Wu JC, Bajwa ZH, Selim MH, Dineen A, et al. Lack of association between migraine headache and patent foramen ovale: results of a case–control study. Circulation 2010;121:1406–12.
89. Woods TD, Harmann L, Purath T, Ramamurthy S, Subramanian S, Jackson S. Small- and moderate- size right-to-left shunts identified by saline contrast echocardiography are normal and unrelated to migraine headache. Chest 2010;138:264–9.
90. Feurer R, Sadikovic S, Sepp D, Esposito L, Schleef M, Bockelbrink A, et al. Patent foramen ovale is not associated with an increased risk of stroke recurrence. Eur J Neurol 2010;17:1339–45.
91. Nozari A, Dilekoz E, Sukhotinsky I, Stein T, Eikermann- Haerter K, Liu C, et al. Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol 2010;67:221–9.
92. Dreier JP. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 2011;17:439–47.
93. Thaler DE, Saver JL. Cryptogenic stroke and patent foramen ovale. Curr Opin Cardiol 2008;23:537–44.
94. Goadsby PJ. Current concepts of the pathophysiology of migraine. Neurol Clin 1997;15:27–42.
95. Moskowitz MA. Genes, proteases, cortical spreading depression and migraine: impact on pathophysiology and treatment. Funct Neurol 2007;22:133–6.
96. Moskowitz MA, Kurth T. Blood vessels, migraine, and stroke. Stroke 2007;38:3117–8.
97. Lauritzen M, Dreier JP, Fabricius M, Hartings JA, Graf R, Strong AJ. Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. J Cereb Blood Flow Metab 2011;31:17–35.
98. Gursoy-Ozdemir Y, Qiu J, Matsuoka N, Bolay H, Bermpohl D, Jin H, et al. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest 2004;113:1447–55.
99. Imamura K, Takeshima T, Fusayasu E, Nakashima K. Increased plasma matrix metalloproteinase-9 levels in migraineurs. Headache 2008;48:135–9.
100. Lauritzen M, Skyhoj Olsen T, Lassen NA, Paulson OB. Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol 1983;13:633–41.
101. Welch KM, Brandes AW, Salerno L, Brandes JL. C- reactive protein may be increased in migraine patients who present with complex clinical features. Headache 2006;46:197–9.
102. Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ. Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 2005;64:614–20.
103. Scher AI, Stewart WF, Ricci JA, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 2003;106:81–9.
104. Bigal ME, Lipton RB. Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology 2006;67:252–7.
105. Bigal ME, Liberman JN, Lipton RB. Obesity and migraine:a population study. Neurology 2006;66:545–50.
106. Bigal ME, Kurth T, Hu H, Santanello N, Lipton RB. Migraine and cardiovascular disease. Possible mechanisms of interaction. Neurology 2009;72:1864–71.
107. Cavestro C, Rosatello A, Micca G, Ravotto M, Marino MP, Asteggiano G, et al. Insulin metabolism is altered in migraineurs: a new pathogenic mechanism for migraine? Headache 2007;47:1436–42.
108. Rist PM, Diener HC, Kurth T, Schurks M. Migraine, migraine aura, and cervical artery dissection: a systematic review and meta-analysis. Cephalalgia 2011;31:886-96.
109. Debette S, Markus HS. The genetics of cervical artery dissection: a systematic review. Stroke 2009;40:e459-66.
110. Tzourio C, El Amrani M, Robert L, Alperovitch A. Serum elastase activity is elevated in migraine. Ann Neurol 2000;47:648-51.
111. Asghar MS, Hansen AE, Amin FM, van der Geest RJ, Koning Pv, Larsson HB, et al. Evidence for a vascular factor in migraine. Ann Neurol 2011; 69: 635–45.
112. Borgdorff P, Tangelder GJ. Migraine: possible role of shear-induced platelet aggregation with serotonin
release. Headache 2012;52:1298–318.
113. Sacco S, Olivieri L, Bastianello S, Carolei A. Comorbid neuropathologies in migraine. J Headache Pain 2006;7:222–30.
114. Sacco S, Cerone D, Carolei A. Comorbid neuropathologies in migraine:an update on cerebrovascular and cardiovascular aspects. J Headache Pain 2008;9:237–48.
115. Heckmann JG, Hilz MJ, Katalinic A, Marthol H, Muck-Weymann M, B Neundörfer. Myogenic cerebrovascular autoregulation in migraine measured by stress transcranial Doppler sonography. Cephalalgia 1998;18:133–7.
116. Smeda JS. Cerebral vascular changes associated with hemorrhagic stroke in hypertension. Can J Physiol Pharmacol 1992;70:552–64.
117. Daneshtalab N, Smeda JS. Alterations in the modulation of cerebrovascular tone and blood flow by nitric oxide synthases in SHRsp with stroke. Cardiovasc Res 2010;86:160–8.
118. Swartz RH, Kern RZ. Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol 2004;61:1366–8.
119. Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, et al. Migraine as a risk factor for subclinical brain lesions. JAMA 2004;291:427–34.
120. Scher AI, Gudmundsson LS, Sigurdsson S, Ghambaryan A, Aspelund T, Eiriksdottir G, et al. Migraine headache in middle age and late- life brain infarcts. JAMA 2009;301:2563–70.
121. Kurth T, Mohamed S, Maillard P, Zhu YC, Chabriat H, Mazoyer B, et al. Headache, migraine, and structural brain lesions and function: population based Epidemiology of Vascular Ageing- MRI study. BMJ 2011;342:c7357.
122. Kruit MC, Launer LJ, Ferrari M, van Buchem MA. Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study. Brain 2005;128:2068-77.
123. Caplan LR, Hennerici M. Impaired clearance of emboli(washout) is an important link between hypoperfusion, embolism, and ischemic stroke. Arch Neurol 1998;55:1475-82.
124. Reinhard M, Schork J, Allignol A, Weiller C, Kaube H. Cerebellar and cerebral autoregulation in migraine. Stroke 2012;43:987-93.
125. Bashir A, Lipton RB, Ashina S, Ashina M. Migraine and structural changes in the brain: A systematic review and meta-analysis. Neurology 2013;81:1260-8.
126. Palm-Meinders IH, Koppen H, Terwindt GM, Launer LJ, Konishi J, Moonen JM, et al. Structural brain
changes in migraine. JAMA 2012;308:1889-97.
127. Wijman CA, Wolf PA, Kase CS, Kelly- Hayes M, Beiser AS. Migrainous visual accompaniments are not rare in late life: the Framingham Study. Stroke 1998;29:1539–43.
128. Olesen J, Friberg L, Olsen TS, Andersen AR, Lassen NA, Hansen PE, et al. Ischaemia-induced (symptomatic) migraine attacks may be more frequent than migraine-induced ischaemic insults. Brain 1993;116:187– 202.
129. Angus-Leppan H. Migraine: mimics, borderlands and chameleons. Pract Neurol 2013;13:308–18.
130. Ducros A, Boukobza M, Porcher R, Sarov M, Valade D, Bousser MG. The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients. Brain 2007;130:3091–101.
131. Call GK, Fleming MC, Sealfon S, Levine H, Kistler JP, Fisher CM. Reversible cerebral segmental vasoconstriction. Stroke 1988;19:1159–70.
132. Bousser MG, Welch KM. Relation between migraine and stroke. Lancet Neurol 2005;4: 533–42. 133. Fisher CM. Late-life migraine accompaniments as a cause of unexplained transient ischemic attacks. Can J Neurol Sci 1980;7:9–17.
134. Izenberg A, Aviv RI, Demaerschalk BM, Dodick DW, Hopyan J, Black SE, et al. Crescendo transient aura attacks: a transient ischemic attack mimic caused by focal subarachnoid hemorrhage. Stroke 2009;40:3725–29.
135. Kurth T, Diener HC, Buring JE. Migraine and cardiovascular disease in women and the role of aspirin: subgroup analyses in the Women’s Health Study. Cephalalgia 2011;31:1106–15.
136. Halkes PH, van Gijn J, Kappelle LJ, Koudstaal PJ, Algra A. Risk indica tors for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin. J Neurol Neurosurg Psychiatry 2009;80:437–9.
137. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA 2002;288:321–33.
138. Detsky ME, McDonald DR, Baerlocher MO, Tomlinson GA, McCrory DC, Booth CM. Does this patient with headache have a migraine or need neuroimaging? JAMA 2006;296:1274–83.
139. Zhu YC, Dufouil C, Tzourio C, Chabriat H. Silent brain infarcts: a review of MRI diagnostic criteria. Stroke 2011;42:1140–5.
140. Hedman C, Andersen AR, Andersson PG, Gilhus NE, Kangasniemi P, Olsson JE, et al. Symptoms of classic migraine attacks: modifications brought about by metoprolol. Cephalalgia 1988;8:279–84.
141. Hall GC, Brown MM, Mo J, MacRae KD. Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice. Neurology 2004;62:563-8.
142. Wammes-van der Heijden EA, Rahimtoola H, Leufkens HG, Tijssen CC, Egberts AC. Risk of ischemic complications related to the intensity of triptan and ergotamine use. Neurology 2006;67:1128-34.
143. Allais G, Gabellari IC, De Lorenzo C, Mana O, Benedetto C. Oral contraceptive in migraine. Expert Rev Neurother 2009;9:381-93.
144. Edlow AG, Bartz D. Hormonal contraceptive options for women with headache: A review of the evidence. Rev Obstet Gynecol 2010;3:55-65.
145. Lampl C, Katsarava Z, Diener HC, Limmroth V. Lamotrigine reduces migraine aura and migraine attacks in patients with migraine with aura. J Neurol Neurosurg Psychiatry 2005;76:1730–2.
146. Rothrock J, North J, Madden K, Lyden P, Fleck P, Dittrich H. Migraine and migrainous stroke: risk factors and prognosis. Neurology 1993;43:2473–6.
147. Laurell K, Lundström E. Migrainous Infarction: Aspects on Risk Factors and Therapy. Curr Pain Headache Rep 2012;16:255–60.
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2019-08-24
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ดุสิตานนท์ เ. Migraine and Stroke. J Thai Stroke Soc [Internet]. 2019 Aug. 24 [cited 2024 Jul. 1];15(2):82-104. Available from: https://he01.tci-thaijo.org/index.php/jtss/article/view/172123
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ข้อความภายในบทความที่ตีพิมพ์ในวารสารสมาคมโรคหลอดเลือดสมองไทยเล่มนี้ ตลอดจนความรับผิดชอบด้านเนื้อหาและการตรวจร่างบทความเป็นของผู้นิพนธ์ ไม่เกี่ยวข้องกับกองบรรณาธิการแต่อย่างใด การนำเนื้อหา ข้อความหรือข้อคิดเห็นของบทความไปเผยแพร่ ต้องได้รับอนุญาตจากกองบรรณาธิการอย่างเป็นลายลักษณ์อักษร ผลงานที่ได้รับการตีพิมพ์ในวารสารเล่มนี้ถือเป็นลิขสิทธิ์ของวารสาร
