CLINICAL STUDY PROTOCOL

Vokes EE,Weichselbaum RR Lippman SM, Hong WK. Head and Neck Cancer. N Engl J Med 1993; 328 : 184 - 194.

Hong WK, Dimery IW. Overview of com bined modality therapies for head and neck cancer. J Natl Cancer Inst 1993; 85 : 95 - 111.

Marcial VA,Pajak TF, Kramer S, et al. Radiation Therapy Oncology Group (RTOG) Studies in head and neck cancer. Semin Oncol. 1988; 16 : 39 - 60.

Parsons JT, Mendenhall WM, Million RR, et al. The management of primary cancers of the oropharynx: Combined treatment or irradiation alone ? Semin Radiat Oncol 1992; 2 : 142 - 148.

Al-Sarraf M. Head and neck cancer che motherapy concepts. Semin Oncol 1988; 15 : 70 - 85.

Stupp R, Weichselbaum RR, Vokes EE. Combined modality therapy of head and neck cancer. Semin Oncol 1994; 21 : 349 - 358.

A randomized trial of combined multidrug chemotherapy and radiotherapy in advanced squamous cell carcinoma of the head and neck: an interim report from the SECOG participants. Eur J Surg Oncol 1986; 12 : 289 - 295.

Adelstein DJ, Sharan VM, Earle AS, et al. Simultaneous versus sequential combined technique therapy for squamous cell head and neck cancer. Cancer 1990; 65 : 1685 - 1691.

Merlano M, Corvo R, Margarino G,et al. Combined chernotherapy and radiation therapy in advanced inoperable squamous cell careinoma of the head and neck : the final report of a randomized trial. Cancer 1991;67 : 915 - 921.

Muggia FM. Overview of carboplatin : Replacing complementing and extending the therapeutic horizons of cisplatin. Semin Oncol 1989; 16 : 7 - 13. (supp. 5)

Forastiere AA, Metch B, Schuller DE, et al. Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous cell carcinoma of the head and neck : A Southwest Oncology Group Study. J Clin Oncol 1992; 10 : 1245 - 1251.

Eisenberger M, van Echo D, Aisner J. Carboplatin : The experience in head and neck cancer. Semin Oncol 1989; 16 : 34 - 41.

Schwachofer JHM, Crooijmans RPAM, Hoogenhout J. Effectiveness in inhibition of recovery of cell survival by cisplatin and carboplatin : influence of treatment sequence. Int J Radiat Oncol Biol Phys 1994; 20 : 1235 - 1241.

Pekkola-Heino K, Kulmala J, Grenman R. Carboplatin radiation interaction in squamous cell carcinoma cell lines. Arch Otolaryngeal Head and Neck Surg 1992; 118 : 1312 - 1315.

Yang LX, Douple EB, Wang HL. Irradiation enhances cellular uptake of carboplatin. Int J Radiat Oncol Biol Phys 1995; 33 : 641 - 646.

Zamboglou N, Schnabel T, Kolotas C, et al. Carboplatin and radiotherapy in the treatment of head and neck cancer: Six years' experience. Semin Oncol 1994; 21: 45 - 53. (supp. 12)

Eisenberger M, Jacobs M. Simultaneous treatment with single-agent chemotherapy and radiation for locally advanced cancer of head and neck. Semin Oncol 1992; 4 : 41 - 46. (supp. 11)

Volling P, Staar S, Achterrath W, Muller RP. Phase I/II study of simultaneous carboplatin and radiotherapy in unresec- table squamous cell carcinoma of the head and neck. Semin Oncol 1992; 19 : 66 - 71. (supp. 2)

Inuyama Y,Fuji M, Mashno S, et al.Clini- cal effect of UFT for head and neck can- cer. Cancer and chemotherapy 1983; 10 : 90 - 96.

Valverde JJ, Ganzale JI. Ncoadjuvant che- motherapy with cisplatin and 5-FU versus cisplatin and UFT in advanced squamous head and neck cancer. Proc. ASCO 1993; 12 : 281.

Calvert AH, Newell DR, Gumbsell LA, et al.Carboplatin : Prospective pharma- cokinetically guided dose-escalation in relation to renal function. Proc. ASCO 1987;6:45.

Phase II Trial of Carboplatin, UFT, and Concurrent Radiotherapy in Locally Advanced Head and Neck Cancer