Development of 192Ir HDR brachytherapy phantom for dosimetric verification and source positioning accuracy

Authors

  • Jettapat Tarasub Division of Radiology, King Chulalongkorn Memorial Hospital
  • Nesara Pattanaphan Radiology Department, Samitivej Sukhumvit Hospital
  • Sakda Kingkaew Division of Radiation Oncology, Department of Radiology, King Chulalongkorn Memorial Hospital
  • Lukkana Apipunyasopon Department of Radiological Technology and Medical Physics, Faculty of Allied Health Sciences, Chulalongkorn University

Keywords:

High dose rate brachytherapy, Remote after-loading system, Optically stimulated luminescence dosimeter, Gafchromic film

Abstract

Backgrounds: Brachytherapy is a treatment method in which an encapsulated radioactive source placed at short distance from the tumor to deliver the high radiation dose to the target while sparing normal tissues. Due to its steep dose gradient, the lack of proper monitoring system has led to treatment delivery errors. Therefore, the development of device for verifying the dose delivery and the source positon accuracy is essential.

Objective: The main objective of this study was to develop a prototype phantom for dosimetric measurement and source positioning check in 192Ir high dose-rate (HDR) brachytherapy treatment.

Materials and Methods: The phantom size of 30×30×5 cm3 was designed on shapr3D application and built from acrylic material. It was composed of a single channel for source placement via needle applicator, 20 slots for holding the Optically stimulated luminescence dosimeter (OSLD), and a single slot for placing the film. The computed tomography of our phantom was acquired and imported into the Oncentra treatment planning system (TPS). The test plan was created and delivered into the phantom using the Flexitron HDR afterloader. The source dwell position and calculate absorbed dose was investigated by the Gafchromic EBT3 film and nanoDots OSLD, respectively.

Results: The phantom was rigid and simple enough to be used for dosimetric measurement with OSLD and assessing the source dwell position with Gafchromic film. The average CT number of the phantom was equal to 149.86±3.89 HU. The deviations of the source position were observed to be within ±1 mm. The average difference in point dose between the OSLD measurement and TPS calculation was 4.40±2.51%.

Conclusion: Our phantom can be used as a routinely checking tool for assessing the source position and the delivered dose in the quality control procedure of 192Ir brachytherapy unit.

References

Mayadev J, Benedict SH, Kamrava M. Handbook of image-guided brachytherapy. Springer International Publishing. 2017.

Mobit PN, Nguyen A, Packianathan S, He R, Yang C. Dosimetric comparison of brachytherapy sources for high-dose-rate treatment of endometrial cancer: (192)Ir, (60)Co and an electronic brachytherapy source. Br J Radiol. 2016;89:20150449.

Strohmaier S, Zwierzchowski G. Comparison of 60Co and 192Ir sources in HDR brachytherapy. J Contemp Brachyth. 2011;3:199-208.

Skowronek J. Current status of brachytherapy in cancer treatment – short overview. J Contemp Brachyth. 2017;9:581-9.

Gabriel PF, Jacob GJ, Ryan LS, Luc B, Sam B, Gustavo K, et al. In vivo dosimetry in brachytherapy: Requirements and future directions for research, development, and clinical practice. Phys Imag Radiat Oncol. 2020;16:1-11.

Steenhuijsen J, Harbers M, Hoffmann A, de Leeuw A, Rijnders A, Unipan M. Code of Practice for Quality Assurance of Brachytherapy with Ir-192 Afterloaders Report 30. Netherlands Commission on Radiation Dosimetry. 2018.

Awunor OA. Assessment of a source position checking tool for the quality assurance of transfer tubes used in HDR 192Ir brachytherapy treatments. Brachyth. 2018;17:628-33.

Aldelaijan S, Devic S, Bekerat H, Papaconstadopoulos P, Schneider J, Seuntjens J, et al. Positional and angular tracking of HDR 192Ir source for brachytherapy quality assurance using radiochromic film dosimetry. Med Phys. 2020;47:6122-39.

Nath R, Anderson LL, Luxton G, Weaver KA, Williamson JF, Meigooni AS. Dosimetry of interstitial brachytherapy sources: recommendations of the AAPM Radiation Therapy Committee Task Group No.43. American Association of Physicists in Medicine. Med Phys. 1995;22:209-34.

Rivard MJ, Coursey BM, Hanson WF, Huq MS, Ibbott GS, Mitch MG, et al. Update of AAPM Task Group No.43 Report: A revised AAPM protocol for brachytherapy dose calculations. Med Phys. 2004;31:633-74.

Rivard MJ, Bulter WM, Dewerd LA, Huq MS, Ibbott GS, Meigooni AS, et al. Supplement to the 2004 update of the AAPM Task Group No.43 Report. Med Phys. 2007;34:2187-205.

Palmer AL, Nisbet A, Bradley D. Verification of high dose rate brachytherapy dose distributions with EBT3 Gafchromic film quality control techniques. Phys Med Biol. 2013;58:497-511.

Ayoobian N, AsI AS, Poorbaygi H, Javanshir MR. Gafchromic film dosimetry of a new HDR 192Ir brachytherapy source. J Appl Clin Med Phys. 2016;17:194-205.

Deward LA, Liang Q, Reed JL, Culberson WS. The use of TLDs for brachytherapy dosimetry. Rad Meas. 2014;71:276-81.

Jaselske E, Adliene D, Rudzianskas V, Urbonavicius GB, Inciura A. In vivo dose verification method in catheter based high dose rate brachytherapy. Phys Med. 2017;44:1-10.

Espinoza A, Petasecca M, Fuduli I, Howie A, Bucci J, et al. The evaluation of a 2D diode array in “magic phantom” for use in high dose rate brachytherapy pretreatment quality assurance. Med Phys. 2015;42:663-73.

Jursinic PA. Characterization of optically stimulated luminescent dosimeters, OSLDs for clinical dosimetric measurements. Med Phys. 2007;34(:4594-604.

Christopher JT, Robert EI, Jessica RH, Bruce C, Edward S. Optically stimulated luminescent dosimetry for high dose rate brachytherapy. Front Oncol. 2012;2:1-7.

GAFChromicTM EBT3 film specification, Available from: www.gafchromic.com

Elekta Flexitron afterloader, Available from: www.elekta.com

Microstar user guide version 5.0. Landauer; 2015.

Nath R, Anderson LL, Meli JA, Olch AJ, Stitt JA, Williamson JF. Code of practice for brachytherapy physics: Report of the AAPM Radiation Therapy Committee Task Group No.56. Med Phys. 1997;24:1557-98.

Code of Practice for Quality Assurance of Brachytherapy with Ir-192 Afterloaders Report 30. Netherlands Commission of Radiation Dosimetry; 2018.

Johansen JG, Rylander S, Buus S, Bentzen L, Hokland SB, Sondergaard CK, et al. Time-resolved in vivo dosimetry for source tracking in brachytherapy. Brachyth. 2018;17:122-32.

Tissue Characterization Phantom Model 467 User’s guide, Available from: www.gammex.com

Ghorbani M, Salahshour F, Haghparast A, Maghaddas TA, Knaup C. Effect of tissue composition on dose distribution in brachytherapy with various photon emitting sources. J Contemp Brachyth. 2014;6:54-67.

Anderson CE, Nielsen SK, Greilich S, Helt-Hansen J, Lindegaard JC, Tanderup K. Characterization of a fiber-coupled Al2O3:C luminescence dosimetry system for online in vivo dose verification during 192Ir brachytherapy. Med Phys. 2009;36:708-18.

Tien CJ, Ebeling R, Hiatt JR, Curran B, Sternick E. Optically stimulated luminescent dosimetry for high dose rate brachytherapy. Front Oncol. 2012;2:1-7.

Tanderup K, Beddar S, Andersen CE, Kertzscher G, Cygler JE. In vivo dosimetry in brachytherapy. Med Phys. 2013;40:1-15.

Downloads

Published

2021-09-21

How to Cite

1.
Tarasub J, Pattanaphan N, Kingkaew S, Apipunyasopon L. Development of 192Ir HDR brachytherapy phantom for dosimetric verification and source positioning accuracy. J Thai Assn of Radiat Oncol [Internet]. 2021 Sep. 21 [cited 2024 Nov. 15];27(2):R43-R59. Available from: https://he01.tci-thaijo.org/index.php/jtaro/article/view/250025

Issue

Section

Original articles