Multigene assay as a prognostic and predictive tool for chemotherapy treatment in Early breast cancer
Keywords:
Multigene assay, Early breast cancer, chemotherapyAbstract
Treatment of ER+ HER2- early breast cancer composes not only surgery, radiation and hormonal therapy, but also chemotherapy. Weighing side effect versus benefit of chemotherapy should be considered. In the past, decision was made from clinicopathological risk factors. Nowadays, gene expression assays can represent chemotherapy benefit in individual tumor and can be used to determine if chemotherapy should be given or not. Even though all multigene assays reflect risk of recurrence, they differ substantially in the technological platform, i.e. the number and identity of genes assessed, the patient populations that were used for development and validation, and the level of evidence supporting clinical utility. These differences could impact physicians’ decision regarding to cost-effectiveness in different scenarios.
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