The Effect of Overall Treatment Time of Radiotherapy to Local Control of Disease in Head and Neck Cancer

Authors

  • Rungarun Kittichest Faculty of Medicine, Chiang Mai University
  • Imjai Chitapanarux Faculty of Medicine, Chiang Mai University
  • Vicharn Lorvidhaya Faculty of Medicine, Chiang Mai University
  • Pimkhuan Kamnerdsupaphon Faculty of Medicine, Chiang Mai University
  • Vimol Sukthomya Faculty of Medicine, Chiang Mai University

Abstract

Background : Radiotherapy is commonly used in the management of patients with squamous cell carcinoma of head and neck. Various studies showed the total treatment time effect tumor control.

Purpose : To evaluate the effect of prolonged overall treatment time to the tumor control in squamous cell carcinoma of head and neck.

Methods and materials : Data from 114 patients with histological confirmed squamous cell carcinoma of head and neck (excluded nasopharyngeal cancer) were treated with radiotherapy at Department of Radiation Oncology, Chiang mai University, since 2001 (2544) - 2003 (2546), attention in duration of response and overall survival.

Results : All 114 squamous cell carcinoma of head and neck patients were treated with radiotherapy differentiated into two groups by total treatment time, group A:6-8 weeks and group B: more than 8 weeks. Median overall treatment time was 55.8 days (range 42-88 days). Overall 4-years locoregional progression rate were 47.7% for group A and 60.7% for group B, respectively (p=0.3532). Four year overall survival was 98.7% for group A and 83.3% for group B (p=0.4310).

Conclusion : The prolongation of overall treatment time trends to have poorer outcome in locoregional control and overall survival.

References

Quynh-Thu XL, Karen KF, Steward K, Janice KR, Jeanne MQ, Thomas SM, Richard MK, Theodore LP. Influence of fraction size, total dose and overall time on local control of T1-T2 glotic cancer. Int J Radiat Oncol Biol Phys 1997; 39(1):115-126.

Overgaard J, Hjelm-Hansen M, Johansen LV, Andersen AP. Comparison of conventional and split-course radiotherapy as primary treatment in carcinoma of larynx. Acta Oncol 1988; 27:147-152.

Withers HR, Taylor JMG, Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 1998; 27:131-146.

Hendry JH, Bentzen SM, Dale RG, et al. A modeled comparison of the effect of using different ways to compensate for missed treatment days in radiotherapy. Clin Oncol 1996; 8:297-307.

Slevin NJ, Hendry JH, Roberts SA, Agren-Cronqvist A. The effects of increasing the treatment time beyond three weeks on the control of T2 and T3 laryngeal cancer using radiotherapy. Radiother Oncol 1992; 24:215-220.

Fowler JF. Radiobiological modeling to compensate for unplanned gaps in radiation treatment. International Congress of Radiation Research, Dublin, July, 1999. In Radiation Research, Vol 2 Proceedings. Moriaty M, Mothersill C, Seymour C,
Eddington M, Ward JF, Fry RJM, eds. Oak Brook, IL, U.S.A.: Int Assoc Rad Res 2000:653-659.

Fowler JF, Chappell R. Non small cell lung tumors repopulate rapidly during radiation therapy. Int J Radiat Oncol Biol Phys 2000; 46:516-517.

Overgaard J, Hansen HS, Specht L, et al. Five compared with six fractions per week of conventional radiation of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomized controlled trial. Lancet 2003; 362:933-940.

Murao T, Morita K. Influence of overall treatment time of radiotherapy on local control for T2 cancer of tongue. Nippon Igaku Hoshasen Gakkai Zasshi 1993 Aug 25; 53(8):940-944.

Allal AS, de Pree C, Dulguerov P, Bierei S, Maire D, Kurtz JM. Avoidance of treatment interruption: an unrecognized benefit of accelerated radiotherapy in oropharyngeal carcinoma? Int J Radiat Oncol Biol Phys 1999;45:41-45.

Wang CC, Efird JT. Does prolonged treatment course adversely affect local control of carcinoma of the larynx. Int J Radiat Oncol Biol Phys 1983; 29:657-660.

Ingue T, Teshima T, Mureyama S, Yamazaki H, Nose T, Tanaka E. Overall time in telecobalt therapy for T1 glottic carcinoma treated with 2 Gy per day. Strahlenther Onkol 1995; 171:475-477.

Fowler JF, Lindstrom MJ. Loss of local control with prolongation in radiotherapy. Int J Radiat Oncol Bio Phys 1992; 23(2):457-467.
vol13No1

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Published

2007-12-28

How to Cite

1.
Kittichest R, Chitapanarux I, Lorvidhaya V, Kamnerdsupaphon P, Sukthomya V. The Effect of Overall Treatment Time of Radiotherapy to Local Control of Disease in Head and Neck Cancer. J Thai Assn of Radiat Oncol [Internet]. 2007 Dec. 28 [cited 2024 Nov. 15];13(2):37-45. Available from: https://he01.tci-thaijo.org/index.php/jtaro/article/view/203567

Issue

Vol. 13 No. 2 (2007): July – December

Section

Original articles

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