Cisplatin vs. Mitomycin in Concurrent with Radiotherapy for Locally Advanced Cervical Cancer
Abstract
Purpose The primary objective of this study was to compare the time to progression and overall survival of the 2 concurrent radiochemotherapy regimens (radiation + mitomycin vs. radiation + cisplatin) for locally advanced cervical cancer. The secondary objective was to estimate the response rates and toxicities of the 2 treatment arms.
References
Parkin DM, Laara E, Muir CS. Estimates of the worldwide frequency of sixteen major cancer in 1980. Int J Cancer 1988; 41: 184-197.
Petterson F. (Ed). 22nd Annual Report on the results of treatment in gynecological cancer, FIGO 1994.
Chiang Mai Cancer Registry ; Annual Report 1999 Vol. 22, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University.
Omura GA. Current status of chemotherapy for cancer of the cervix, Oncology (Huntigt) 1992; 6: 27-32.
Morton GC, Thomas GM. Does adjuvant chemotherapy change the prognosis of cervical cancer, Curr Opin Obstet Gynecol 1996; 8: 17-20.
Ludgate SM, Crandom AJ. Synchronous 5-FU, mitomycin and radiation therapy in the treatment of locally advanced carcinoma of teh cervix; Int J Radiat Oncol Biol Phys 1988; 15: 893-99.
Friedlander ML, Atkonson K et al. The integration of chemotherapy into the management of locally advanced cervical cancer : a pilot study ; Gynecol Oncol 1984; 19: 1-7.
Sardi JE, Giaroli A, Sananes C et al. Long-term follow-up of the first randomized trial using neoadjuvant chemotherapy in stage IB squamous carcinoma of the cervix: the final results; Gynecol Oncol 1997; 67 (1): 61-9.
Thigpen T, Shingleton H et al. Cis-platinum in treatment of advanced or recurrent squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group; Cancer 1981; 48: 899-903.
Potish RA, Twiggs LB, Adcock LL, Savage JE, Prem KA, Levitt SH. Effect of cis platinum on tolerance to radiation therapy in advanced cervical cancer; Am J Clin Oncol 1986; 9: 387-91.
Chen MD, Paley PJ et al. Phase I trial of Taxol as a radiation sensitizer with cisplatin in advanced cervical cancer; Gynecol Oncol 1997; 67: 131-6.
Fishmen A, Chiu JK et al. Phase I-II study of combined 5-fluoruracil and cisplatin chemotherapy and altered fractionation radiotherapy for advanced squamous cell carcinoma of the cervix; Ann J Clin Oncol 1997; 20: 342-7.
Skov KA, Farell NP et al. Platinum complexes with one radiosensitizing ligand [PtCl2(NH3)(sensitizer)]: radiosensitization and toxicity studies in vitro; Radiatres 1987; 112; 273-82.
Skov KA, Korbelik M et al. The interaction of trans-DDP[PtCl2(NH3)2] with low doses of radiation in mammalian cells; Int J Radiat Oncol Biol Phys 1989; 16: 1281-4.
Herman TS, Teicher BA et al. Effect of acidic pH on radiosensitization of FSaIIC cells in vitro by misonidazole, etanidazole, or cis-diamminedichloroplatinum (II); Radiat Res 1990; 124: 28-33.
Skov KA, Macphail HS et al. The effect of radiosensitizers on the survival response of hypoxic mammalian cells: the low X- ray dose region, hypersensitivity and induced radioresistance;Radiat Res 1994; 138(Suppl 1): 113-6.
Chougule PB, Suk S et al. Cisplatin as a radiation sensitizer in the treatment of advanced head and neck cancers. Results of a phase II study; Cancer 1994; 74: 1927-32.
Richmond RC, Simic MG. Effect of radiation on cis-dichlorodiammineplatinum(II) and DANN in aqueous solution; Br J Cancer Suppl 1978; 37: 20-23.
Pearcy RG, Stuart GC et al. Phase II study to evaluate the toxicity and efficacy of concurrent cisplatin and radiation therapy in the treatment of patients with locally advanced squamous cell carcinoma of the cervix; Gynecol Oncol 1995; 58: 34-41.
Choo YC, Choy TK, Et al. Potentiation of radiotherapy by cis-dichlorodiammine platinum (II) in advanced cervical carcinoma; Gynecol Oncol 1986; 23: 94-100.
Potish RA, Twiggs LB et al. Effect of cis-platinum on tolerance to radiation therapy in advanced cervical cancer; Am J Clin Oncol 1986; 9: 387-91.
Keys HM, Bundy BN et al. Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stgae IB cervical carcinoma. N Eng J Med 1999; 1154-1161.
Morris M, Eifel PJ et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high risk cervical cancer. N Eng J Med 1999; 340 : 1137 - 1143.
Peters WA, Liu PY et al. Cisplatin, 5-fluorouracil plus radiation therapy are superior to radiation therapy as adjunctive in high-risk, early stage carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a report of a phase III
Inter-Group study SGO 30th annual meeting, Mar 1999#1.
Rose PG, Bundy BN, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Eng J Med 1999; 340: 1144-1153.
Whitney CW, Sause W, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group
and Southwest Oncology Group Study. J Clin Oncol. 1999; 17: 1339-1348.
Lorvidhaya V, Chitapanarux I, Sangruchi S, et al. Concurrent Mitomycin 5-Fluorouracil, and radiotherapy in the treatment of locally advanced carcinoma of the cervix: A Randomized Trial. Int J Radiation Oncology Biol Phys 2003; 55: 1226-1232.
Petterson F. (Ed). 22nd Annual Report on the results of treatment in gynecological cancer, FIGO 1994.
Chiang Mai Cancer Registry ; Annual Report 1999 Vol. 22, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University.
Omura GA. Current status of chemotherapy for cancer of the cervix, Oncology (Huntigt) 1992; 6: 27-32.
Morton GC, Thomas GM. Does adjuvant chemotherapy change the prognosis of cervical cancer, Curr Opin Obstet Gynecol 1996; 8: 17-20.
Ludgate SM, Crandom AJ. Synchronous 5-FU, mitomycin and radiation therapy in the treatment of locally advanced carcinoma of teh cervix; Int J Radiat Oncol Biol Phys 1988; 15: 893-99.
Friedlander ML, Atkonson K et al. The integration of chemotherapy into the management of locally advanced cervical cancer : a pilot study ; Gynecol Oncol 1984; 19: 1-7.
Sardi JE, Giaroli A, Sananes C et al. Long-term follow-up of the first randomized trial using neoadjuvant chemotherapy in stage IB squamous carcinoma of the cervix: the final results; Gynecol Oncol 1997; 67 (1): 61-9.
Thigpen T, Shingleton H et al. Cis-platinum in treatment of advanced or recurrent squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group; Cancer 1981; 48: 899-903.
Potish RA, Twiggs LB, Adcock LL, Savage JE, Prem KA, Levitt SH. Effect of cis platinum on tolerance to radiation therapy in advanced cervical cancer; Am J Clin Oncol 1986; 9: 387-91.
Chen MD, Paley PJ et al. Phase I trial of Taxol as a radiation sensitizer with cisplatin in advanced cervical cancer; Gynecol Oncol 1997; 67: 131-6.
Fishmen A, Chiu JK et al. Phase I-II study of combined 5-fluoruracil and cisplatin chemotherapy and altered fractionation radiotherapy for advanced squamous cell carcinoma of the cervix; Ann J Clin Oncol 1997; 20: 342-7.
Skov KA, Farell NP et al. Platinum complexes with one radiosensitizing ligand [PtCl2(NH3)(sensitizer)]: radiosensitization and toxicity studies in vitro; Radiatres 1987; 112; 273-82.
Skov KA, Korbelik M et al. The interaction of trans-DDP[PtCl2(NH3)2] with low doses of radiation in mammalian cells; Int J Radiat Oncol Biol Phys 1989; 16: 1281-4.
Herman TS, Teicher BA et al. Effect of acidic pH on radiosensitization of FSaIIC cells in vitro by misonidazole, etanidazole, or cis-diamminedichloroplatinum (II); Radiat Res 1990; 124: 28-33.
Skov KA, Macphail HS et al. The effect of radiosensitizers on the survival response of hypoxic mammalian cells: the low X- ray dose region, hypersensitivity and induced radioresistance;Radiat Res 1994; 138(Suppl 1): 113-6.
Chougule PB, Suk S et al. Cisplatin as a radiation sensitizer in the treatment of advanced head and neck cancers. Results of a phase II study; Cancer 1994; 74: 1927-32.
Richmond RC, Simic MG. Effect of radiation on cis-dichlorodiammineplatinum(II) and DANN in aqueous solution; Br J Cancer Suppl 1978; 37: 20-23.
Pearcy RG, Stuart GC et al. Phase II study to evaluate the toxicity and efficacy of concurrent cisplatin and radiation therapy in the treatment of patients with locally advanced squamous cell carcinoma of the cervix; Gynecol Oncol 1995; 58: 34-41.
Choo YC, Choy TK, Et al. Potentiation of radiotherapy by cis-dichlorodiammine platinum (II) in advanced cervical carcinoma; Gynecol Oncol 1986; 23: 94-100.
Potish RA, Twiggs LB et al. Effect of cis-platinum on tolerance to radiation therapy in advanced cervical cancer; Am J Clin Oncol 1986; 9: 387-91.
Keys HM, Bundy BN et al. Cisplatin, radiation and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stgae IB cervical carcinoma. N Eng J Med 1999; 1154-1161.
Morris M, Eifel PJ et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high risk cervical cancer. N Eng J Med 1999; 340 : 1137 - 1143.
Peters WA, Liu PY et al. Cisplatin, 5-fluorouracil plus radiation therapy are superior to radiation therapy as adjunctive in high-risk, early stage carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a report of a phase III
Inter-Group study SGO 30th annual meeting, Mar 1999#1.
Rose PG, Bundy BN, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Eng J Med 1999; 340: 1144-1153.
Whitney CW, Sause W, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group
and Southwest Oncology Group Study. J Clin Oncol. 1999; 17: 1339-1348.
Lorvidhaya V, Chitapanarux I, Sangruchi S, et al. Concurrent Mitomycin 5-Fluorouracil, and radiotherapy in the treatment of locally advanced carcinoma of the cervix: A Randomized Trial. Int J Radiation Oncology Biol Phys 2003; 55: 1226-1232.
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Published
2008-12-30
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Kamnerdsupaphon P, Chitapanarux I, Sukthomya V, Lorvidhaya V, Tharavichikul E. Cisplatin vs. Mitomycin in Concurrent with Radiotherapy for Locally Advanced Cervical Cancer. J Thai Assn of Radiat Oncol [Internet]. 2008 Dec. 30 [cited 2024 Jul. 3];14(2):63-70. Available from: https://he01.tci-thaijo.org/index.php/jtaro/article/view/203553
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บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของวารสารมะเร็งวิวัฒน์ ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับ และบุคคลากรท่านอื่น ๆ ใน สมาคมฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
