Proton therapy in head and neck cancers
Abstract
การฉายรังสีด้วยโปรตอน (proton) ได้รับความสนใจมากขึ้น เนื่องจากคุณสมบัติทางฟิสิกส์ของโปรตอนจะถ่ายทอดรังสี ปริมาณสูงไปยังจุดปลายพิสัยในเนื้อเยื่อหรือจุดที่โปรตอนหยุดเคลื่อนที่ เรียกว่า Bragg peak หลังจากนั้นปริมาณรังสีจะลดลง อย่างรวดเร็ว ดังนั้นเนื้อเยื่อปกติหรืออวัยวะข้างเคียงบริเวณด้านหน้าและด้านหลังของก้อนมะเร็งจึงได้รับปริมาณรังสีน้อยมาก ซึ่งแตกต่างจากรังสีเอกซเรย์พลังงานสูงที่ใช้กันอย่างแพร่หลายในปัจจุบันหรือโฟตอน (photon) มีการศึกษามากมายที่แสดง ให้เห็นความสามารถของโปรตอนในการลดปริมาณรังสีไปสู่อวัยวะข้างเคียงหรือ organs at risk (OARs) [1] ซึ่งมะเร็งศีรษะและ ลำคอเป็นหนึ่งในโรคมะเร็งที่ผู้ป่วยได้รับผลข้างเคียงระหว่างและภายหลังการฉายรังสีมาก เนื่องจากก้อนมะเร็งและอวัยวะข้าง เคียงอยู่ในระยะประชิดกัน เพราะฉะนั้นการฉายรังสีในมะเร็งศีรษะและลำคอจึงอาจได้ประโยชน์จากคุณสมบัติทางของโปรตอน จากคำแนะนำด้านนโยบายการใช้และการเบิกจ่ายเพื่อการฉายรังสีโปรตอนโดย American Society for Radiation Oncology หรือ ASTRO model policy เผยแพร่ในปี 2017 [2] ได้จัดมะเร็งศีรษะและลำคอระยะลุกลามเฉพาะที่หรือระยะ T4 หรือไม่ สามารถผ่าตัดได้ มะเร็งของโพรงไซนัส และมะเร็งที่ต้องฉายรังสีซ้ำ อยู่ในกลุ่มมะเร็งที่มีหลักฐานทางคลินิกที่สนับสนุนการใช้ โปรตอน บทความฉบับนี้จึงได้รวบรวมหลักฐานและงานวิจัยต่างๆ เกี่ยวกับการฉายรังสีด้วยโปรตอนในโรคมะเร็งศีรษะและ ลำคอที่พบได้บ่อย ดังจะกล่าวถัดไป
References
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Proton Beam Therapy (PBT) Model Policy. American Society for Radiation Oncology website. https://www.astro.org/uploadedFiles/_MAIN_SITE/Daily_Practice/Reimbursement/Model_Policies/Content_Pieces/ASTROPBTModelPolicy.pdf Approved June, 2017.
Blanco AI, Chao KS, Ozyigit G, Adli M, Thorstad WL, Simpson JR, et al. Carcinoma of paranasal sinuses: long-term outcomes with radiotherapy. Int J Radiat Oncol Biol Phys 2004;59:51-8.
Wiegner EA, Daly ME, Murphy JD, Abelson J, Chapman CH, Chung M, et al. Intensity-modulated radiotherapy for tumors of the nasal cavity and paranasal sinuses: clinical outcomes and patterns of failure. Int J Radiat Oncol Biol Phys 2012;83:243-51.
Jang NY, Wu HG, Park CI, Heo DS, Kim DW, Lee SH, et al. Definitive radiotherapy with or without chemotherapy for T3-4N0 squamous cell carcinoma of the maxillary sinus and nasal cavity. Jpn J Clin Oncol 2010;40:542-8.
Hoppe BS, Nelson CJ, Gomez DR, Stegman LD, Wu AJ, Wolden SL, et al. Unresectable carcinoma of the paranasal sinuses: outcomes and toxicities. Int J Radiat Oncol Biol Phys 2008;72:763-9.
Duthoy W, Boterberg T, Claus F, Ost P, Vakaet L, Bral S, et al. Postoperative intensity-modulated radiotherapy in sinonasal carcinoma: clinical results in 39 patients. Cancer 2005;104:71-82.
Patel SH, Wang Z, Wong WW, Murad MH, Buckey CR, Mohammed K, et al. Charged particle therapy versus photon therapy for paranasal sinus and nasal cavity malignant diseases: a systematic review and meta-analysis. The Lancet Oncology 2014;15:1027-38.
Ramaekers BL, Pijls-Johannesma M, Joore MA, van den Ende P, Langendijk JA, Lambin P, et al. Systematic review and meta-analysis of radiotherapy in various head and neck cancers: comparing photons, carbonions and protons. Cancer Treat Rev 2011;37:185-201.
Malyapa RS, Mendenhall WM, Yeung D, McKenzie C, Li Z, Morris CG, et al. Outcomes of Nasal Cavity and Paranasal Sinus Cancers Treated With Proton Therapy. Int J Radiat Oncol Biol Phys 2012;84:S498.
Nakamura T, Azami Y, Ono T, Yamaguchi H, Hayashi Y, Suzuki M, et al. Preliminary results of proton beam therapy combined with weekly cisplatin intra-arterial infusion via a superficial temporal artery for treatment of maxillary sinus carcinoma. Jpn J Clin Oncol 2016;46:46-50.
Dagan R, Bryant C, Li Z, Yeung D, Justice J, Dzieglewiski P, et al. Outcomes of Sinonasal Cancer Treated With Proton Therapy. Int J Radiat Oncol Biol Phys 2016;95:377-85.
Zenda S, Kohno R, Kawashima M, Arahira S, Nishio T, Tahara M, et al. Proton beam therapy for unresectable malignancies of the nasal cavity and paranasal sinuses. Int J Radiat Oncol Biol Phys 2011;81:1473-8.
Nishimura H, Ogino T, Kawashima M, Ishikura S, Nihei K, Onozawa M, et al. Preliminary result of proton beam therapy for malignancies of the nasal cavity and paranasal sinus-with special reference to adverse effects on optic pathways. Int J Radiat Oncol Biol Phys 2004;60:S512-S3.
Russo AL, Adams JA, Weyman EA, Busse PM, Goldberg SI, Varvares M, et al. Long-Term Outcomes After Proton Beam Therapy for Sinonasal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys 2016;95:368-76.
Toyomasu Y, Demizu Y, Matsuo Y, Sulaiman NS, Mima M, Nagano F, et al. Outcomes of Patients With Sinonasal Squamous Cell Carcinoma Treated With Particle Therapy Using Protons or Carbon Ions. Int J Radiat Oncol Biol Phys 2018;101:1096-103.
Schmidt MQ, David J, Yoshida EJ, Scher K, Mita A, Shiao SL, et al. Predictors of survival in head and neck mucosal melanoma. Oral Oncol 2017;73:36-42.
Zenda S, Kawashima M, Nishio T, Kohno R, Nihei K, Onozawa M, et al. Proton beam therapy as a nonsurgical approach to mucosal melanoma of the head and neck: a pilot study. Int J Radiat Oncol Biol Phys 2011;81:135-9.
Zenda S, Akimoto T, Mizumoto M, Hayashi R, Arahira S, Okumura T, et al. Phase II study of proton beam therapy as a nonsurgical approach for mucosal melanoma of the nasal cavity or para-nasal sinuses. Radiother Oncol 2016;118:267-71.
Michel G, Joubert M, Delemazure AS, Espitalier F, Durand N, Malard O. Adenoid cystic carcinoma of the paranasal sinuses: retrospective series and review of the literature. Eur Ann Otorhinolaryngol Head Neck Dis 2013;130:257-62.
Linton OR, Moore MG, Brigance JS, Summerlin DJ, McDonald MW. Proton therapy for head and neck adenoid cystic carcinoma: initial clinical outcomes. Head Neck 2015;37:117-24.
Pommier P, Liebsch NJ, Deschler DG, Lin DT, McIntyre JF, Barker FG, 2nd, et al. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 2006;132:1242-9.
Holliday E, Bhattasali O, Kies MS, Hanna E, Garden AS, Rosenthal DI, et al. Postoperative Intensity-Modulated Proton Therapy for Head and Neck Adenoid Cystic Carcinoma. Int J Part Ther 2016;2:533-43.
Bhattasali O, Holliday E, Kies MS, Hanna EY, Garden AS, Rosenthal DI, et al. Definitive proton radiation therapy and concurrent cisplatin for unresectable head and neck adenoid cystic carcinoma: A series of 9 cases and a critical review of the literature. Head Neck 2016;38 Suppl 1:E1472-80.
Al-Mamgani A, van Rooij P, Mehilal R, Tans L, Levendag PC. Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. Eur Arch Otorhinolaryngol 2013;270:293-9.
Gamez ME, Lal D, Halyard MY, Wong WW, Vargas C, Curtis K, et al. Outcomes and Patterns of Failure for Sinonasal Undifferentiated Carcinoma (SNUC): The Mayo Clinic Experience. Int J Radiat Oncol Biol Phys 2016;94:954.
Lu YC, Adams JA, Clark JR, Liebsch N, Chan AW. Induction chemotherapy followed by concurrent chemotherapy and proton beam for sinonasal undifferentiated carcinoma. J Clin Oncol 2017;35:e17557-e.
Bell D. Sinonasal Neuroendocrine Neoplasms: Current Challenges and Advances in Diagnosis and Treatment, with a Focus on Olfactory Neuroblastoma. Head Neck Pathol 2018;12:22-30.
Bhattacharyya N, Thornton AF, Joseph MP, Goodman ML, Amrein PC. Successful treatment of esthesioneuroblastoma and neuroendocrine carcinoma with combined chemotherapy and proton radiation. Results in 9 cases. Arch Otolaryngol Head Neck Surg 1997;123:34-40.
Fitzek MM, Thornton AF, Varvares M, Ancukiewicz M, McIntyre J, Adams J, et al. Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy. Cancer 2002;94:2623-34.
Nakamura N, Zenda S, Tahara M, Okano S, Hayashi R, Hojo H, et al. Proton beam therapy for olfactory neuroblastoma. Radiother Oncol 2017;122:368-72.
Al-Sarraf M, LeBlanc M, Giri PG, Fu KK, Cooper J, Vuong T, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 1998;16:1310-7.
Wee J, Tan EH, Tai BC, Wong HB, Leong SS, Tan T, et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol 2005;23:6730-8.
Chen Y, Sun Y, Liang S-B, Zong J-F, Li W-F, Chen M, et al. Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China. Cancer 2013;119:2230-8.
Lee AW, Tung SY, Chua DT, Ngan RK, Chappell R, Tung R, et al. Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 2010;102:1188-98.
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Holliday EB, Garden AS, Rosenthal DI, Fuller CD, Morrison WH, Gunn GB, et al. Proton Therapy Reduces Treatment-Related Toxicities for Patients with Nasopharyngeal Cancer: A Case-Match Control Study of Intensity-Modulated Proton Therapy and Intensity-Modulated Photon Therapy. Int J Part Ther 2015;2:19-28.
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Proton Beam Therapy (PBT) Model Policy. American Society for Radiation Oncology website. https://www.astro.org/uploadedFiles/_MAIN_SITE/Daily_Practice/Reimbursement/Model_Policies/Content_Pieces/ASTROPBTModelPolicy.pdf Approved June, 2017.
Blanco AI, Chao KS, Ozyigit G, Adli M, Thorstad WL, Simpson JR, et al. Carcinoma of paranasal sinuses: long-term outcomes with radiotherapy. Int J Radiat Oncol Biol Phys 2004;59:51-8.
Wiegner EA, Daly ME, Murphy JD, Abelson J, Chapman CH, Chung M, et al. Intensity-modulated radiotherapy for tumors of the nasal cavity and paranasal sinuses: clinical outcomes and patterns of failure. Int J Radiat Oncol Biol Phys 2012;83:243-51.
Jang NY, Wu HG, Park CI, Heo DS, Kim DW, Lee SH, et al. Definitive radiotherapy with or without chemotherapy for T3-4N0 squamous cell carcinoma of the maxillary sinus and nasal cavity. Jpn J Clin Oncol 2010;40:542-8.
Hoppe BS, Nelson CJ, Gomez DR, Stegman LD, Wu AJ, Wolden SL, et al. Unresectable carcinoma of the paranasal sinuses: outcomes and toxicities. Int J Radiat Oncol Biol Phys 2008;72:763-9.
Duthoy W, Boterberg T, Claus F, Ost P, Vakaet L, Bral S, et al. Postoperative intensity-modulated radiotherapy in sinonasal carcinoma: clinical results in 39 patients. Cancer 2005;104:71-82.
Patel SH, Wang Z, Wong WW, Murad MH, Buckey CR, Mohammed K, et al. Charged particle therapy versus photon therapy for paranasal sinus and nasal cavity malignant diseases: a systematic review and meta-analysis. The Lancet Oncology 2014;15:1027-38.
Ramaekers BL, Pijls-Johannesma M, Joore MA, van den Ende P, Langendijk JA, Lambin P, et al. Systematic review and meta-analysis of radiotherapy in various head and neck cancers: comparing photons, carbonions and protons. Cancer Treat Rev 2011;37:185-201.
Malyapa RS, Mendenhall WM, Yeung D, McKenzie C, Li Z, Morris CG, et al. Outcomes of Nasal Cavity and Paranasal Sinus Cancers Treated With Proton Therapy. Int J Radiat Oncol Biol Phys 2012;84:S498.
Nakamura T, Azami Y, Ono T, Yamaguchi H, Hayashi Y, Suzuki M, et al. Preliminary results of proton beam therapy combined with weekly cisplatin intra-arterial infusion via a superficial temporal artery for treatment of maxillary sinus carcinoma. Jpn J Clin Oncol 2016;46:46-50.
Dagan R, Bryant C, Li Z, Yeung D, Justice J, Dzieglewiski P, et al. Outcomes of Sinonasal Cancer Treated With Proton Therapy. Int J Radiat Oncol Biol Phys 2016;95:377-85.
Zenda S, Kohno R, Kawashima M, Arahira S, Nishio T, Tahara M, et al. Proton beam therapy for unresectable malignancies of the nasal cavity and paranasal sinuses. Int J Radiat Oncol Biol Phys 2011;81:1473-8.
Nishimura H, Ogino T, Kawashima M, Ishikura S, Nihei K, Onozawa M, et al. Preliminary result of proton beam therapy for malignancies of the nasal cavity and paranasal sinus-with special reference to adverse effects on optic pathways. Int J Radiat Oncol Biol Phys 2004;60:S512-S3.
Russo AL, Adams JA, Weyman EA, Busse PM, Goldberg SI, Varvares M, et al. Long-Term Outcomes After Proton Beam Therapy for Sinonasal Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys 2016;95:368-76.
Toyomasu Y, Demizu Y, Matsuo Y, Sulaiman NS, Mima M, Nagano F, et al. Outcomes of Patients With Sinonasal Squamous Cell Carcinoma Treated With Particle Therapy Using Protons or Carbon Ions. Int J Radiat Oncol Biol Phys 2018;101:1096-103.
Schmidt MQ, David J, Yoshida EJ, Scher K, Mita A, Shiao SL, et al. Predictors of survival in head and neck mucosal melanoma. Oral Oncol 2017;73:36-42.
Zenda S, Kawashima M, Nishio T, Kohno R, Nihei K, Onozawa M, et al. Proton beam therapy as a nonsurgical approach to mucosal melanoma of the head and neck: a pilot study. Int J Radiat Oncol Biol Phys 2011;81:135-9.
Zenda S, Akimoto T, Mizumoto M, Hayashi R, Arahira S, Okumura T, et al. Phase II study of proton beam therapy as a nonsurgical approach for mucosal melanoma of the nasal cavity or para-nasal sinuses. Radiother Oncol 2016;118:267-71.
Michel G, Joubert M, Delemazure AS, Espitalier F, Durand N, Malard O. Adenoid cystic carcinoma of the paranasal sinuses: retrospective series and review of the literature. Eur Ann Otorhinolaryngol Head Neck Dis 2013;130:257-62.
Linton OR, Moore MG, Brigance JS, Summerlin DJ, McDonald MW. Proton therapy for head and neck adenoid cystic carcinoma: initial clinical outcomes. Head Neck 2015;37:117-24.
Pommier P, Liebsch NJ, Deschler DG, Lin DT, McIntyre JF, Barker FG, 2nd, et al. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg 2006;132:1242-9.
Holliday E, Bhattasali O, Kies MS, Hanna E, Garden AS, Rosenthal DI, et al. Postoperative Intensity-Modulated Proton Therapy for Head and Neck Adenoid Cystic Carcinoma. Int J Part Ther 2016;2:533-43.
Bhattasali O, Holliday E, Kies MS, Hanna EY, Garden AS, Rosenthal DI, et al. Definitive proton radiation therapy and concurrent cisplatin for unresectable head and neck adenoid cystic carcinoma: A series of 9 cases and a critical review of the literature. Head Neck 2016;38 Suppl 1:E1472-80.
Al-Mamgani A, van Rooij P, Mehilal R, Tans L, Levendag PC. Combined-modality treatment improved outcome in sinonasal undifferentiated carcinoma: single-institutional experience of 21 patients and review of the literature. Eur Arch Otorhinolaryngol 2013;270:293-9.
Gamez ME, Lal D, Halyard MY, Wong WW, Vargas C, Curtis K, et al. Outcomes and Patterns of Failure for Sinonasal Undifferentiated Carcinoma (SNUC): The Mayo Clinic Experience. Int J Radiat Oncol Biol Phys 2016;94:954.
Lu YC, Adams JA, Clark JR, Liebsch N, Chan AW. Induction chemotherapy followed by concurrent chemotherapy and proton beam for sinonasal undifferentiated carcinoma. J Clin Oncol 2017;35:e17557-e.
Bell D. Sinonasal Neuroendocrine Neoplasms: Current Challenges and Advances in Diagnosis and Treatment, with a Focus on Olfactory Neuroblastoma. Head Neck Pathol 2018;12:22-30.
Bhattacharyya N, Thornton AF, Joseph MP, Goodman ML, Amrein PC. Successful treatment of esthesioneuroblastoma and neuroendocrine carcinoma with combined chemotherapy and proton radiation. Results in 9 cases. Arch Otolaryngol Head Neck Surg 1997;123:34-40.
Fitzek MM, Thornton AF, Varvares M, Ancukiewicz M, McIntyre J, Adams J, et al. Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy. Cancer 2002;94:2623-34.
Nakamura N, Zenda S, Tahara M, Okano S, Hayashi R, Hojo H, et al. Proton beam therapy for olfactory neuroblastoma. Radiother Oncol 2017;122:368-72.
Al-Sarraf M, LeBlanc M, Giri PG, Fu KK, Cooper J, Vuong T, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 1998;16:1310-7.
Wee J, Tan EH, Tai BC, Wong HB, Leong SS, Tan T, et al. Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol 2005;23:6730-8.
Chen Y, Sun Y, Liang S-B, Zong J-F, Li W-F, Chen M, et al. Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China. Cancer 2013;119:2230-8.
Lee AW, Tung SY, Chua DT, Ngan RK, Chappell R, Tung R, et al. Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 2010;102:1188-98.
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2018-12-27
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กิจพาณิชย์ ส. Proton therapy in head and neck cancers. J Thai Assn of Radiat Oncol [Internet]. 2018 Dec. 27 [cited 2024 Nov. 15];24(2):48-63. Available from: https://he01.tci-thaijo.org/index.php/jtaro/article/view/203030
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บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของวารสารมะเร็งวิวัฒน์ ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับ และบุคคลากรท่านอื่น ๆ ใน สมาคมฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
