Effectiveness of metformin prescription practices guideline to prevent metformin associated lactic acidosis in a diabetic patient at the Somdejphrajoataksin Maharaj Hospital
Keywords:
metformin, lactic acidosis, metabolic acidosis, rational drug use, practice guideline, metformin prescriptionAbstract
Objective: To study the effectiveness of metformin prescription practices guideline to prevent metformin associated lactic acidosis (MALA) in diabetic patients at Somdejphrajoataksin Maharaj Hospital
Methodology: This study was an interrupt time study that selected all type 2 diabetes patients receiving metformin from the outpatient department of the Somdejphrajoataksin Maharaj Hospital from January 1, 2023 to December 31, 2023. The research tools were metformin prescription practices to prevent MALA, compilation of data using medication error record form, drug-related adverse events record form. Data was analyzed by frequency, percentage, and Chi’s square test.
Results: The studies were 3,671 patients. Before using the metformin prescription practices guideline there were 1,654 unreasonably prescriptions (13.75%) and after using the guideline, there were 109 unreasonably prescriptions (0.82%), that was a significantly reduced unreasonably prescriptions (p=0.001). Incidence of MALA after using the guideline was significantly lower than before using the guideline (p = 0.002). There were 30 (0.89%) MALA incidents and reduced to 12 (0.33%) after using the guideline.
Conclusion: The metformin prescription practices guideline can reduce the number of prescriptions that were unreasonably prescribed, as well as statistically significantly reduce the incidence of MALA occurrences.
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