Mortality and renal recovery in acute kidney injury patients requiring dialysis: A single-center study
Keywords:
acute kidney injury, renal dialysis, renal recovery, mortality rateAbstract
Acute kidney injury requiring dialysis (AKI-D) is a medical emergency with reported incidence rates ranging from 3% to 20%, and associated mortality rates as high as 45% to 70%. This study aimed to investigate renal recovery rates and mortality in AKI-D patients. This single-center retrospective study included 50 adult patients diagnosed with AKI-D who were admitted between January 2019 and December 2023. Data were collected from medical records and statistically analyzed to identify factors influencing kidney recovery. During the 90-day follow-up period following the initiation of dialysis, 27 patients (54%) survived and achieved renal recovery, while 22 patients (44%) died, and one patient (2%) progressed to end-stage renal disease. In the subgroup of patients who achieved renal recovery, the average creatinine level at 90 days was 1.81 ± 1.04, and the mean estimated glomerular filtration rate (eGFR) was 52.77 ± 32.48. Compared to the non-recovery group, the renal recovery group had lower exposure to vasoactive drugs (33% vs. 65%; p = 0.025), fewer intradialytic hypotension events (15% vs. 52%; p = 0.005), longer renal replacement therapy duration (median 15 vs. 6 days; p < 0.001), and a longer hospital stay (mean 35.4 days vs. 17 days; p = 0.002). In conclusion, the renal recovery rate was 54%, and the mortality rate was 44%. Factors potentially impacting renal recovery include exposure to vasoactive drugs and the occurrence of intradialytic hypotension. Targeting these factors for therapeutic intervention may improve patient outcomes
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