Prevalence and pathological characteristics of benign and sarcomatous lesions in the abdominal cavity and retroperitoneum among adult at Thammasat University Hospital

Authors

  • Natcha Poungmeechai Department of Pathology, Faculty of Medicine, Thammasat University
  • Jutatip Kintarak Department of Pathology, Faculty of Medicine, Thammasat University

Keywords:

soft tissue tumors, abdominal cavity, retroperitoneum, clinicopathological findings

Abstract

Soft tissue tumors pose a challenge due to their rarity and complex diagnostic process. This pilot study aimed to investigate the prevalence and clinicopathological features of soft tissue tumors in the abdominal cavity and retroperitoneum in adults at Thammasat University Hospital. This descriptive retrospective study included patients aged at least 15 years who had undergone core needle biopsy and were diagnosed with soft tissue tumors according to the WHO classification of soft tissue and bone 2020. A total of 56 cases were collected by the Department of Pathology over 5 years from January 2017 to December 2021. Benign tumors accounted for 41.1% and sarcomas for 58.9% of the cases. The mean age of the patients was 53.5 years, ranging from 15 to 92 years, with 25 (44.6%) cases being female and 31 (55.4%) cases male. Most tumors were located in the abdominal cavity, with the majority being larger than 5 cm. Among sarcomas, 21.2% exhibited multiple foci. The most common sarcoma identified was gastrointestinal stromal tumor (GIST), while the most common benign tumor was PEComa. Incidental findings were observed in 35.7% of cases. The prevalence and clinicopathological findings of this study were consistent with previous research findings.

References

Sassa N. Retroperitoneal tumors: Review of diagnosis and management. Int J Urol. 2020;27:1058-70. doi:10.1111/iju.14361.

WHO classification of tumours of soft tissue and bone. 5th ed. Lyon (France): IARC Press; 2020.

Goldblum J.R., Folpe A.L., Weiss S.W. Enzinger & Weiss’s soft tissue tumors. 7th ed. Philadelphia, PA: Elsevier; 2020

Muzaffer; TOKGÖZ A. Diagnosis and treatment approaches for intraabdominal masses in adults. Ankara Üniversitesi Tıp Fakültesi Mecmuası 2017;70:201-5.

Sogaard AS, Laurberg JM, Sorensen M, et al. Intraabdominal and retroperitoneal soft-tissue sarcomas--outcome of surgical treatment in primary and recurrent tumors. World J Surg Oncol 2010;8:81. doi:10.1186/1477-7819-8-81.

Mannan K, Briggs TW. Soft tissue tumours of the extremities. BMJ 2005;331:590. doi:10.1136/bmj.331.7517.590.

Hareerak T, Kintarak J. Benign and Malignant Soft Tissue Tumors of Extremities in Adults at Thammasat University Hospital. AMJAM 2021;21:114-8.

Sassa N, Yokoyama Y, Nishida Y, et al. Clinical characteristics and surgical outcomes of retroperitoneal tumors: a comprehensive data collection from multiple departments. Int J Clin Oncol 2020;25:929-36. doi:10.1007/s10147-020-01620-1.

Syam Sundar B, Grandhi B, Shanthi V, et al. Clinico Pathological Evaluation of Benign and Malignant Soft Tissue Tumors-2 Years Retrospective Study. JMSCR 2016;4:10822-32.

Dutta C, Kumari P, Ahmad S. A Retrospective Clinicopathological Assessment of Soft Tissue Tumors at the Tertiary Care Centre of North Bihar. EJMCM 2021;08:1280-6.

Reshadi H, Rouhani A, Mohajerzadeh S, et al. Prevalence of malignant soft tissue tumors in extremities: an epidemiological study in syria. Arch Bone Jt Surg 2014;2:106-10.

Toro JR, Travis LB, Wu HJ, et al. Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978-2001: An analysis of 26,758 cases. Int J Cancer 2006;119:2922-30.

Baste B, Swami S, Narhire V, et al. A clinico‐pathologic study of soft tissue neoplasms: An experience from a rural tertiary care hospital. Ann Trop Med Pub Health 2017;10:348.

Jain P, Shrivastava A, Malik R. Clinicomorphological assessment of soft tissue tumors. Sah J App Med Sci 2014;2:886–90.

Gronchi A, Miceli R, Shurell E, et al. Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets. J Clin Oncol 2013;31:1649-55.

Huggett BD, Cates JMM. The Vanderbilt staging system for retroperitoneal sarcoma: a validation study of 6857 patients from the National Cancer Database. Mod Pathol 2019;32:539–45.

Levy AD, Manning MA, Al-Refaie WB, et al. Soft-tissue sarcomas of the abdomen and pelvis: Radiologic-pathologic features, part 1—common sarcomas:from the radiologic pathology archives. Radio Graphics 2017;37:462-83.

Sharma AK, de la Torre J, IJzerman NS, et al. Location of Gastrointestinal Stromal Tumor (GIST) in the Stomach Predicts Tumor Mutation Profile and Drug Sensitivity. Clin Cancer Res 2021;27:5334-42.

Zagars GK, Ballo MT, Pisters PW, et al. Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy. Cancer 2003;97:2530–43.

Theodosopoulos T, Dellaportas D, Psychogiou V, et al. Multifocal retroperitoneal sarcoma. Case Rep Surg 2013;2013:763702

Anaya DA, Lahat G, Liu J, et al. Multifocality in retroperitoneal sarcoma: a prognostic factor critical to surgical decision-making. Ann Surg 2009;249:137-42.

Downloads

Published

2024-04-30

How to Cite

1.
Poungmeechai N, Kintarak J. Prevalence and pathological characteristics of benign and sarcomatous lesions in the abdominal cavity and retroperitoneum among adult at Thammasat University Hospital. J Med Health Sci [Internet]. 2024 Apr. 30 [cited 2024 Jul. 22];31(1):168-75. Available from: https://he01.tci-thaijo.org/index.php/jmhs/article/view/269288

Issue

Section

Short communication (บทความวิจัยอย่างสั้น)