A comparative outcomes of Nifedipine and Terbutaline in inhibiting preterm labor at Samutsakhon Hospital
Keywords:
Nifedipine, Terbutaline,, Inhibiting preterm labor, preterm laborAbstract
Preterm delivery stands as the main leading cause of perinatal morbidity and mortality. Consequently, tocolytic therapy for delaying preterm delivery holds significant importance. Commonly used tocolytic agents in Thailand include Nifedipine and Terbutaline, each with varied outcomes concerning pregnancy prolongation and effects on infants. This retrospective study aims to compare maternal outcomes and neonatal effects between Nifedipine and Terbutaline in inhibiting preterm labor at Samutsakhon Hospital. Samples comprised pregnant women with preterm labor meeting inclusion criteria, with 58 patients in the oral Nifedipine group and 124 patients in the intravenous Terbutaline group. Data were collected from medical records between January 1, 2021, and December 31, 2022, and statistical analysis employed Chi-square test, Independent t-test, and Multiple logistic regression. Results revealed no statistical differences in maternal age, body mass index, number of pregnancies, parity, abortion and preterm labor history, gestational age, antenatal care, cervical dilatation, and effacement in both groups. In terms of maternal outcomes, significant differences between Nifedipine and Terbutaline included the duration of inhibition (hours) (55.54±17.07 vs. 42.76±16.01, p<0.001) and the percentage of prolonged gestation at 7 days (63.79% vs. 34.68%; aOR 3.01, 95%CI 1.40-6.01, p<0.001). Regarding neonatal outcomes, differences were noted in Apgar score at 1 minute (7.78±1.12 vs. 6.73±2.21, p=0.001), birth weight (grams) (2,257.67±686.77 vs. 1,972.26±610.00, p=0.008), percentage of transfer to NICU (8.62% vs. 24.19%; aOR 0.34, 95%CI 0.12-0.80, p=0.040), and respiratory distress syndrome (22.41% vs. 45.97%; aOR 0.36, 95%CI 0.17-0.77, p=0.008). In conclusion, the use of Nifedipine in inhibiting preterm labor demonstrated more effective outcomes than Terbutaline in terms of prolonging gestation and neonatal effects, along with ease of drug administration.
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