Efficacy of tranexamic acid for reducing blood loss after caesarean section on women with previous caesarean sections: A randomized controlled trial

Abstract

Abstract

            Postpartum hemorrhage is the most common obstetric complication, especially in the case of a caesarean section. International studies have shown that tranexamic acid is effective in preventing blood loss during and after caesarean section. This study aims to examine efficacy of tranexamic acid for reducing blood loss following a caesarean section. A double-blind randomized and controlled trial method was employed in this study. The sample consisted of pregnant women who had previously received a caaesarean section. The students were divided into experimental and control groups, with 36 students per group. The experimental group received 1g of tranexamic acid and the control group received 9.0% NSS 20ml. The primary outcomes compared mean blood loss, and hematocrit volume after birth. The secondary outcomes were to examine the incidence of postpartum haemorrhage, and adverse events. The statistics were analyzed using chi square test and an independent t-test and there were no statistical differences in terms of age, number of pregnancies, parity, gestational age, maternal weight and height, hematocrit, birth weight and duration of caesarean section in both groups. The mean blood loss was significantly lower in the experimental group than the control group (740.58 ± 139.57 and 853.53 ± 163.67, p = 0.002). ). The mean haematocrit was significantly higher in the experimental group than the control group (35.50 ± 3.29 and 33.92 ± 3.03, p 0.037). ). The incidence of postpartum haemorrhage was significantly lower in the experimental group than the control group (5.56%, 25.00, p = .046.0). There were no statistical differences in the adverse events of both groups. In conclusion, 1 mg of tranexamic acid was effective for reducing blood loss and the incidence of postpartum hemorrhage in women with a previous caesarean section.