Sensitivity and specificity of fine needle aspiration cytological report in thyroid nodule at Her Royal Highness Princess Maha Chakri Sirindhorn Medical Center
Keywords:
thyroid nodule, thyroid tumor, fine needle aspiration, Bethesda system, cytology reportingAbstract
Abstract
Thyroid nodules may be investigated by various tests. Fine needle aspiration is one such test, which is easy, convenient, safe, fast, and effective. However, the cytology results are based on the method of obtaining specimens and the expertise of the pathologist. Therefore, the predictive value of cancer by FNA cytological reports from each hospital may vary from the Bethesda system for reporting cytopathology (BSRTC). For this reason, this study aimed to compare the sensitivity, specificity, accuracy and the positive predictive value of cytological reports in Her Royal Highness Princess Maha Chakri Sirindhorn Medical Center (MSMC) with BSRTC. A retrospective and diagnostic testing of all patients with thyroid nodules with FNA cytological reports in MSMC were conducted. The samples consisted of 133 patients and the information was collected at MSMC between October 1, 2012 and September 30, 2018. The factors included age, gender, cytological reports on fine needle aspiration and surgical pathology from excision. The sensitivity, specificity and diagnostic accuracy were 71.9%, 96.4% and 95%, respectively. The positive predictive value was 62.2%. These parameters were standard and close to that of other studies.
References
Jiang H, Tian Y, Yan W, et al. The Prevalence of thyroid nodules and an analysis of related Lifestyle factors in Beijing communities. Int J Environ Res Public Health 2016;13:442.
Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016;26:1-133.
Gunes P, Demirturk P, Aker F, et al. Evaluation of fine-veedle aspiration of thyroid nodules in a series of 1,100 Patients: Correlation between cytology and Histopathology Original Article. Indian J Surg 2015;77:990-5.
Alhashem MH, Alabidi A, Aly MG. The Bethesda system for reporting thyroid cytopathology: A retrospective review of its diagnostic utility at Johns Hopkins Aramco Healthcare, Saudi Arabia. Am J
Otolaryngol 2021;42:103088.
Huang J, Shi H, Song M, et al. Surgical Outcome and Malignant Risk Factors in Patients With thyroid nodule classified as Bethesda category III. Front Endocrinol (Lausanne) 2021;12:686849.
Ali. SZ, Cibas ES. The Bethesda system for reporting thyroid cytopathology. 2nd ed. Switzerland: Springer International Publishing; 2017.
Machala E, Sopinski J, Iavorska I, et al. Correlation of fine needle aspiration cytology of thyroid gland with histopathological rjesults. Pol Przegl Chir 2018;90:1-5.
Nandedkar SS, Dixit M, Malukani K, et al. Evaluation of thyroid lesions by fineneedle aspiration cytology according to bethesda system and its histopathological correlation. Int J Appl Basic Med Res 2018;
:76-82.
Bongiovanni M, Spitale A, Faquin WC, et al. The Bethesda system for reporting thyroid cytopathology: A meta-analysis. Acta Cytol 2012;56:333-9.
Sheffield BS, Masoudi H, Walker B, et al. Preoperative diagnosis of thyroid nodules using the Bethesda system for reporting thyroid cytopathology: A comprehensive review and meta-analysis. Expert Rev Endocrinol Metab 2014;9:97-110.
Perez LA, Gupta PK, Mandel SJ, et al. Thyroid papillary microcarcinoma. Is it really a pitfall of fine needle aspiration cytology? Acta Cytol 2001;45:341-6.
Harach HR, Saravia DE, Zusman SB. Occult papillary microcarcinoma of the thyroid—a potential pitfall of fine needle aspiration cytology? J Clin Pathol 1991;44:205-7.
Na HY, Moon JH, Choi JY, et al. Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and
carcinoma: Analysis of cause of under- or misdiagnoses. PLoS One 2020;15:e0241597.
Park KW, Shin JH, Hahn SY, et al. Ultrasound-guided fine-needle aspiration or core needle biopsy for diagnosing follicular thyroid carcinoma? Clin Endocrinol 2020;92:468-74.
Alshoabi SA, Binnuhaid AA. Diagnostic accuracy of ultrasonography versus fineneedle-aspiration cytology for predicting benign thyroid lesions. Pak J Med Sci 2019; 35:630-5.
Hang JF, Lilo MT, Bishop JA, et al. Diagnostic Accuracy of Fine Needle Aspiration in Thyroid Nodules Arising in Patients with Graves Disease. Acta Cytol 2017;61:117-24.
Roy PK, Bandyopadhyay S, Dubey AB, et al. A Comparative Study on Aspiration Cytology and Histopathology in Diagnosis of Thyroid Nodule and Its Correlation. Indian J Otolaryngol Head Neck Surg 2019;71:997-1001.
Singh P, Gupta N, Dass A, et al. Correlation of fine needle aspiration cytology with histopathology in patients undergoing thyroid surgery. Otolaryngol Pol 2020; 75:1-5.
Erkinuresin T, Demirci H. Diagnostic accuracy of fine needle aspiration cytology of thyroid nodules. Diagnosis (Berl) 2020; 7:61-6.
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