The duration of chronic kidney disease development amongst type 2 diabetes patients: A systematic review and meta-analysis


  • Kanmanee Sangkhaphan
  • Piyawan Kaewthorn
  • Patchari Kwankapho
  • Wiparat Yokphuang
  • Tum Boonrod
  • Witchada Simla
  • Sirirat Sriraksa


diabetes type 2, chronic kidney disease, systematic review, meta-analysis


Diabetes is chronic disease and it is public health problem in Thailand. The International Diabetes Federation (IDF) reported that number of diabetics has increased up to 48% of world population. Thailand is country in Western pacific region and reveals top five diabetic number which is about 4.4 million. Diabetes could lead complication to the individual patients. Kidney foundation of Thailand found that the prevalence of chronic kidney among diabetic has raised nearly 30%. It is estimated that eight million kidney patients are caused by type two diabetes. The researchers thus interested in studying the duration of chronic kidney disease (CKD) development amongst type 2 diabetics to know about photogenes of CKD in each stage. We can use the data as guideline to prevent diabetes patient from developing such disease. The systematic review and meta-analysis were based on papers published from 2009 to 2019 through PudMed, Web Of Science, Google Scholar and Science Direct. We included 24 papers that met the inclusion criteria. Later, we analysed the data using STATA program. It concluded that type 2 diabetes patient took 7.5 years (95% CI = 6.73-8.28) to develop CKD stage 1; 9.73 years (95% CI = 8.73-10.73) to reach stage 2; 12.08 years (95% CI = 10.09-14.07) to progress stage 3. It showed 17.08 years (95% CI = 13.31-20.80) to become stage 4-5. Therefore, diabetes patients should check glomerular filtration rate regularly to screen renal dysfunction. Medical health providers can use the findings to prevent and delay the duration of renal dysfunction among diabetes patients.


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