The Correlations of Baseline Autonomic Nervous System Function and Hostility Score with Change Ratio of Treatment Response in Generalized Anxiety Disorder ANS index and hostility in GAD

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Tsung-Hua Lu
Lan-Ting Lee
Shuo-En Hsu
Kao Chin Chen
I Hui Lee
Tzung Lieh Yeh
Po See Chen
Yen Kuang Yang


                         The relationship between the autonomic nervous system (ANS) index, hostility scale and generalized anxiety disorder (GAD) in the long-term treatment outcome has been rarely studied. The aim of this study was to explore whether the ANS index and hostility scale at baseline are predictors of long-term outcome in GAD. Nine patients with GAD were recruited. At baseline (week 0), blood pressure (BP), heart rate (HR), and mean heart rate range (MHRR) were measured as ANS index; the Cook–Medley Hostility Scale was assessed as hostility. The Hamilton Anxiety Rating Scale (HAM-A) was administered at baseline, short-term (week 6) and long-term (week 52). The aggressive response subscale of the hostility scale was significantly negatively correlated with the HAM-A change ratio in short-term and long-term, while MHRR were significantly positively correlated with these change ratios. The MHRR and the aggressive response subscale at baseline could be predictors of long-term outcome in GAD.


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Lu, T.-H., Lee, L.-T., Hsu, S.-E., Chen, K. C., Lee, I. H., Yeh, T. L., Chen, P. S., & Kuang Yang, Y. (2019). The Correlations of Baseline Autonomic Nervous System Function and Hostility Score with Change Ratio of Treatment Response in Generalized Anxiety Disorder: ANS index and hostility in GAD. International Journal of Child Development and Mental Health, 7(1), 20-17. Retrieved from
Original Articles
Author Biography

Yen Kuang Yang, 3Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan

Distinguished Professor , M.D. Head, Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan Chief, Department of Psychiatry, National Cheng Kung University Hospital Dou-Liou Branch Visiting Staff Psychiatrist Department of Psychiatry, College of Medicine and Hospital National Cheng Kung University, Tainan, Taiwan Education: M.D. Kaohsiung Medical University, Kaohsiung, Taiwan Expertized in; 1. Psychiatry 2. Neuroimaging 3. Neurocognition


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