การเปรียบเทียบระดับวิตามินดีและแมกนีเซียมในเลือดผู้ป่วย ไฟโบรมัยอัลเจียกับคนปกติ
การเปรียบเทียบระดับวิตามินดีและแมกนีเซียมในเลือดผู้ป่วย ไฟโบรมัยอัลเจียกับคนปกติ
Keywords:
fibromyalgia, vitamin D, magnesiumAbstract
Objectives: To compare serum total vitamin D (25(OH) D) levels and plasma magnesium levels between patients with fibromyalgia syndrome (FMS) and age and sex matched normal control population.
Study design: Age and sex matched cross-sectional study
Setting: Out patients of Department of Rehabilitation Medicine, Faculty of Medicine Siriraj hospital
Subjects: A total of 40 FMS patients diagnosed by the ACR 2010 criteria and 40 age and sex matched normal controls (mean age = 45 years, 36 females and 4 males in each groups) from August to October 2014. All participants had no underlying disease and did not take any medication, vitamin D or magnesium supplement influencing the laboratory results.
Methods: Participants’ blood was collected for total serumvitamin D and plasma magnesium levels. The results werecompared between each group.
Results: The mean value of serum total serum vitamin D concentration in FMS group was 0.5 (SD 0.1) ng/mL higher than normal controls (mean 24.6 (SD 7.5) and 24.1 (SD 8.5) ng/mL, respectively, p=0.813). The mean value of plasma magnesium levels was 0.1 (SD 0.02) mg/dL higher in fibromyalgia group than control [mean 2.1 (SD 0.18) and 2.0 (SD 0.16) mg/dL, respectively, p=0.108).
Conclusion: There was no statistically significant difference in mean total serum vitamin D and plasma magnesium levels between fibromyalgia and control group.
References
2. Ittipongsathorn N, Phonghanyudh T, Nitikornatiwat P. Prevalence of fibromyalgia at the physical medicine and rehabilitation outpatient clinic in Phramongkutklao Hospital. J Thai Rehabil Med. 2016;26:24-30.
3. Ballantyne JC, Eisenberg E, Fricton JR, Giamberardino MA, Goh CR, Jadad AR, et al. Update on Fibromyalgia Syndrome. Pain Clinical Updates (IASP). 2008;18:1-5.
4. Wolfe F, Clauw DJ, Fitzcharles M-A, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity. Arthritis Care Res (Hoboken). 2010;62:600-10.
5. Five Differential Diagnoses to Fibromyalgia Syndrome [Internet]. 2008 [Cited 2014 Oct 30] Available from http://fibroaction.org/Articles/Five-Differential- Diagnoses-to-Fibromyalgia-Syndrome-.aspx
6. Boonyaratvej N. ตำราเสริมสร้างประสบการณ์ทางออโธปิดิคส์ Vitamin D. Nontaburi: Bliss communication publishing; 2543; 70.
7. Soontrapa S, Soontrapa S, Chailurkit L, Sakondhavat C, Kaewrudee S, Somboonporn W, et al. Prevalence of hypovitaminosis D in elderly women living in urban area of Khon Kaen province, Thailand. J Med Assoc Thai.2001;84 Suppl:S534-41.
8. Wannasilp N, Kerdhangsoong A, Sribhen K. Reference range of ELECSYS® vitamin D (25-OH) total in healthy Thai men population. Clin Chen Lab Med. 2014;52 Special Suppl:S1753.
9. Abokrysha NT. Vitamin D deficiency in woman with fibromyalgia in Saudi Arabia Pain Medicine. 2012;13: 452–8.
10. Bhatty SA, Shaikh NA, Irfan M, Syed MK, Vaswani AS, Sumbha A et al. Vitamin D deficiency in Fibromyalgia. JPMA. 2010;60:949-51.
11. Wilhelm JD, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5 Suppl:i3-i14.
12. Swaminathan R. Magnesium metabolism and its disorder. Clin Biochem Rev. 2003;24:47-66.
13. Wannasilp N, Poungvarin N, Pokum S, Leowattana W, Mahanonda N. Serum magnesium in Thai coronary artery disease patients. J Med Assoc Thai. 2001;84 Suppl3: S645-9.
14. Matthana MH. The relation between vitamin D deficiency and fibromyalgia syndrome in woman. Saudi Med J. 2011;32:925-29.
15. Hess MW, Hoenderop JGJ, Bindels RJM, Drenth JPH. Systemic review: hypomagnesemia induced by proton pump inhibitor. Aliment Pharmacol Ther. 2012;36:405-13.
16. Omer FS, Engin T, Yasemin T, Cevval U. The relationship between serum trace element levels and clinical parameters in patients with fibromyalgia. Rheumatol Int. 2008;28: 1117-21.
