Prevalence and Potential Associated Factors of Poststroke Depression

  • Dajpratham P Department of Rehabilitation Medicine, Faculty of Medicine Siriraj Hospital
  • Pukrittayakamee P
  • Atsariyasing W
  • Wannarit K
  • Boonhong J
  • Pongpirul K
  • Suesuwan O
  • Chatdharmmaluck S
Keywords: depression, disability, prevalence, stroke


Objectives: To study the prevalence and potential associated factors of poststroke depression (PSD).

Study design: Cross-sectional study.

Setting: Department of Rehabilitation Medicine, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.

Subjects: First ever stroke patients age 45 years old with duration of stroke from 2 weeks to 2 years.

Methods: The included patients were assessed with the Barthel Index (BI) and the Modified Rankin Scale for Neurologic Disability (MRS).  A psychiatric interview according to the diagnostic and statistical manual of mental disorders classification, fifth edition (DSM-5TM) criteria was performed by a psychiatrist. Prevalence was described and potential associated factors of PSD were analyzed with multivariate forward stepwise logistic regression.

Results: Of 115 patients, there were 63 males (54.8%).  Mean age was 64 (SD 10) years old. Median duration of stroke was 59 days. The prevalence of PSD was 20%, 8 of them (6.9%) were diagnosed with major depressive disorder and 15 of them (13.1%) had other depressive disorder. The univariate analysis revealed those with PSD were more disabled according to the MRS (p = 0.04) and had more dependent grooming according to the BI (p = 0.003). With multivariate analysis,only grooming was associated with PSD (odd ratio 4.9; 95%CI 1.6-14.8).

Conclusion: The prevalence of poststroke depression within the first 2 years of those with the first stroke and aged 45 years or older was 20%. Dependence in grooming was the only factor significantly associated with poststroke depression.


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