Pulse transit time in ageing as early biomarker for risk of dementia
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Abstract
A pulse transit time (PTT) was performed as an indicator of arterial stiffness and blood pressure. This aimed to examine a difference between with and without dementia groups in an ageing people. Twenty-eight participants were given their PTT values in a supine posture. The Mini-Mental State Examination scores, systolic blood pressures, diastolic blood pressures, and heart rates were collected in each individual. The main finding was showed that the PTT differed between the groups (P = 0.039). Interestingly, the non-dementia group produced a shorter time of the PTT than the dementia group. This was unaligned evidence to numerous studies. It raised an ageing aspect of a cardiovascular paradox into an explanation. The present study supported that the short time of the PTT was affected by an interaction between the arterial stiffness and the high blood pressure. It was increased a cerebral blood flow, which was lowered to the risk of dementia. The present study summarized that the PTT parameter was an appropriate non-invasive measurement for detecting the development of dementia. In the ageing people, detecting dementia at a pre-stage was beneficial and recommended.
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