Laparoscopic Liver Resection in Ruptured Hepatocellular Carcinoma [with Video]

Current Role of LLR in Ruptured HCC

Authors

  • Nan-ak Wiboonkhwan Department of Surgery, Songklanagarind Vejchavivat Hospital, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

DOI:

https://doi.org/10.31584/psumj.2026283806

Keywords:

Hepatectomy, hepatocellular carcinoma, laparoscopy, laparoscopic hepatectomy, minimally invasive liver resection, ruptured hepatocellular carcinoma

Abstract

Laparoscopic liver resection (LLR) has emerged as a valuable treatment option for managing ruptured hepatocellular carcinoma (HCC). As surgery is one curative treatment of HCC in selected patients, LLR offers advantages over open liver resection (OLR) in terms of reduced blood loss, shorter hospital stays, and comparable postoperative outcomes. While LLR is feasible for non-ruptured HCC, its role in resections of ruptured HCC remains a controversial issue. The primary and secondary aims of this article were to review the current role of LLR, and provide patient selection criteria for ruptured HCC. To date, only 10 cases with good postoperative outcomes have been reported in patients having undergone LLR for ruptured HCC. Patient selection is crucial, along with individualized assessment; based on hemodynamic status, tumor burden and liver function, to guide treatment decisions. In highly selected patients with ruptured tumor, LLR in an experienced center can provide a minimally invasive alternative to OLR; leading to improved patient outcomes. As current evidence relies exclusively on minor hepatectomy case series, further studies are necessary to refine indications and optimize outcomes in this specific context.

References

Reig M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, et al. BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update. J Hepatol 2022;76:681-93. doi: 10.1016/j.jhep.2021.11.018.

Zhu RX, Seto WK, Lai CL, Yuen MF. Epidemiology of hepatocellular carcinoma in the Asia-Pacific region. Gut Liver 2016;10:332-9. doi: 10.5009/gnl15257

Xia F, Ndhlovu E, Zhang M, Chen X, Zhang B, Zhu P. Ruptured hepatocellular carcinoma: current status of research. Front Oncol 2022;12:848903. doi: 10.3389/fonc.2022.848903.

Lai ECH, Lau WY. Spontaneous rupture of hepatocellular carcinoma: a systematic review. Arch Surg 2006;141:191-8. doi: 10.1001/archsurg.141.2.191.

Pillai A, Couri T, Charlton M. Liver allocation policies in the USA: past, present, and the future. Dig Dis Sci 2019;64:985 92. doi: 10.1007/s10620-019-05549-y.

Hashizume M, Takenaka K, Yanaga K, Ohta M, Kajiyama K, Itasaka H, et al. Laparoscopic hepatic resection for hepatocellular carcinoma. Surg Endosc 1995;9:1289-91. doi: 10.1007/BF00190161.

Wong KC, Lee KF, Lo EYJ, Fung AKY, Lok HT, Cheung SYS, et al. Minimally invasive versus open liver resection for hepatocellular carcinoma: a propensity score matching analysis of 224 patients. Langenbecks Arch Surg 2023;408:118. doi: 10.1007/s00423-023-02857-w.

Zhang Y, Huang J, Chen XM, Sun DL. A comparison of laparoscopic versus open left hemihepatectomy for hepatocellular carcinoma. Surg Laparosc Endosc Percutan Tech 2016;26:146-9. doi: 10.1097/SLE.0000000000000247.

El-Gendi A, El-Shafei M, El-Gendi S, Shawky A. Laparoscopic versus open hepatic resection for solitary hepatocellular carcinoma less than 5 cm in cirrhotic patients: a randomized controlled study. J Laparoendosc Adv Surg Tech A 2018;28:302-10. doi: 10.1089/lap.2017.0518.

Gagner M. Laparoscopic partial hepatectomy for liver tumor. Abstract Surg Endosc 1992;6:99.

Buell JF, Cherqui D, Geller DA, O’Rourke N, Iannitti D, Dagher I, et al. The international position on laparoscopic liver surgery: the louisville statement, 2008. Ann Surg 2009;250:825-30. doi: 10.1097/sla.0b013e3181b3b2d8.

Wakabayashi G, Cherqui D, Geller DA, Buell JF, Kaneko H, Han HS, et al. Recommendations for laparoscopic liver resection: a report from the second international consensus conference held in Morioka. Ann Surg 2015;261:619-29. doi: 10.1097/SLA.0000000000001184.

Abu Hilal M, Aldrighetti L, Dagher I, Edwin B, Troisi RI, Alikhanov R, et al. The southampton consensus guidelines for laparoscopic liver surgery: from indication to implementation. Ann Surg 2018;268:11-8. doi: 10.1097/SLA.0000000000002524.

Cheung TT, Han H-S, She WH, Chen K-H, Chow PKH, Yoong BK, et al. The Asia Pacific consensus statement on laparoscopic liver resection for hepatocellular carcinoma: a report from the 7th Asia-Pacific primary liver cancer expert meeting held in Hong Kong. Liver Cancer 2017;7:28-39. doi: 10.1159/000481834.

Zhang H, Liu F, Wen N, Li B, Wei Y. Patterns, timing, and predictors of recurrence after laparoscopic liver resection for hepatocellular carcinoma: results from a high-volume HPB center. Surg Endosc 2022;36:1215-23. doi: 10.1007/s00464 021-08390-5.

Takahara T, Wakabayashi G, Beppu T, Aihara A, Hasegawa K, Gotohda N, et al. Long-term and perioperative outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma with propensity score matching: a multi-institutional Japanese study. J Hepatobiliary Pancreat Sci 2015;22:721-7. doi: 10.1002/jhbp.276.

Yoon Y-I, Kim K-H, Kang S-H, Kim W-J, Shin M-H, Lee SK, et al. Pure laparoscopic versus open right hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a propensity score matched analysis. Ann Surg 2017;265:856-63. doi: 10.1097/SLA.0000000000002072.

Sposito C, Battiston C, Facciorusso A, Mazzola M, Muscarà C, Scotti M, et al. Propensity score analysis of outcomes following laparoscopic or open liver resection for hepatocellular carcinoma. Br J Surg 2016;103:871-80. doi: 10.1002/bjs.10137.

Kabir T, Tan ZZ, Syn NL, Wu E, Lin JD, Zhao JJ, et al. Laparoscopic versus open resection of hepatocellular carcinoma in patients with cirrhosis: meta-analysis. Br J Surg 2021;109:21 9. doi: 10.1093/bjs/znab376.

Cassese G, Han H-S, Lee B, Lee HW, Cho JY, Troisi RI. The role of minimally invasive surgery in the treatment of HCC. Hepatoma Res 2022;8:26. doi: 10.20517/2394-5079.2022.14.

Kim JH, Cho BS, Jang JH. Pure laparoscopic anatomical segment VI resection using the Glissonian approach, Rouviere’s sulcus as a landmark, and a modified liver hanging maneuver (with video). Langenbecks Arch Surg 2018;403:131-5. doi: 10.1007/s00423-018-1652-7.

Tan J, Tan Y, Zhu Y, Chen K, Hu B, Tan H, et al. Perioperative analysis of laparoscopic liver resection with different methods of hepatic inflow occlusion. J Laparoendosc Adv Surg Tech A 2012;22:343-8. doi: 10.1089/lap.2011.0294.

Sugioka A, Kato Y, Tanahashi Y. Systematic extrahepatic Glissonean pedicle isolation for anatomical liver resection based on Laennec’s capsule: proposal of a novel comprehensive surgical anatomy of the liver. J Hepatobiliary Pancreat Sci 2017;24:17-23. doi: 10.1002/jhbp.410.

Machado MAC, Surjan RC, Basseres T, Schadde E, Costa FP, Makdissi FF. The laparoscopic Glissonian approach is safe and efficient when compared with standard laparoscopic liver resection: Results of an observational study over 7 years. Surgery 2016;160:643-51. doi: 10.1016/j.surg.2016.01.017.

Morimoto M, Tomassini F, Berardi G, Mori Y, Shirata C, Abu Hilal M, et al. Glissonean approach for hepatic inflow control in minimally invasive anatomic liver resection: a systematic review. J Hepatobiliary Pancreat Sci 2022;29:51-65. doi: 10.1002/ jhbp.908.

Eguchi S, Kanematsu T, Arii S, Okazaki M, Okita K, Omata M, et al. Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey. Surgery 2008;143:469-75. doi: 10.1016/j. surg.2007.12.003.

Li J, Huang L, Liu CF, Cao J, Yan JJ, Xu F, et al. Risk factors and surgical outcomes for spontaneous rupture of BCLC stages A and B hepatocellular carcinoma: a case-control study. World J Gastroenterol 2014;20:9121-7. doi: 10.3748/wjg.v20.i27.9121.

Zhu LX, Geng XP, Fan ST. Spontaneous rupture of hepatocellular carcinoma and vascular injury. Arch Surg 2001;136:682-7. doi: 10.1001/archsurg.136.6.682.

Zhu Q, Li J, Yan JJ, Huang L, Wu MC, Yan YQ. Predictors and clinical outcomes for spontaneous rupture of hepatocellular carcinoma. World J Gastroenterol 2012;18:7302-7. doi: 10.3748/ wjg.v18.i48.7302.

Goh BKP, Chua DW, Koh YX, Tan EK, Kam JH, Teo JY, et al. Continuous improvements in short and long-term outcomes after partial hepatectomy for hepatocellular carcinoma in the 21st century: Single institution experience with 1300 resections over 18 years. Surg Oncol 2021;38:101609. doi: 10.1016/j. suronc.2021.101609.

Assawasirisin C, Sangserestid P, Sirivatanauksorn Y, Limsrichamrern S, Kositamongkol P, Mahawithitwong P, et al. Factors predicting survival in ruptured hepatocellular carcinoma treated with surgical resection. Siriraj Med J 2022;74:40-7. doi: 10.33192/Smj.2022.6.

Belgaumkar A, Carswell KA, Patel AG. Laparoscopic resection of ruptured liver tumors. J Laparoendosc Adv Surg Tech A 2009;19:641-5. doi: 10.1089/lap.2009.0140.

Xia F, Huang Z, Zhang Q, Ndhlovu E, Zhang M, Chen X, et al. Hepatectomy for ruptured hepatocellular carcinoma classified as Barcelona clinic liver cancer stage 0/A: the optimal treatment. Eur J Surg Oncol 2022;48:2014-22. doi: 10.1016/j. ejso.2022.05.006.

Sada H, Ohira M, Kobayashi T, Tashiro H, Chayama K, Ohdan H, et al. An analysis of surgical treatment for the spontaneous rupture of hepatocellular carcinoma. Digestive Surgery 2015;33:43-50. doi: 10.1159/000441531.

Schmandra TC, Mierdl S, Hollander D, Hanisch E, Gutt C. Risk of gas embolism in hand-assisted versus total laparoscopic hepatic resection. Surg Technol Int 2004;12:137-43.

Uchiyama H, Minagawa R, Itoh S, Kajiyama K, Harimoto N, Ikegami T, et al. Favorable outcomes of hepatectomy for ruptured hepatocellular carcinoma: retrospective analysis of primary R0-Hepatectomized patients. Anticancer Res 2016;36:379-85.

Yoshiya S, Iwaki K, Sakai A, Fujita S, Kawasaki T, Yoshizumi F, et al. Laparoscopic left hepatectomy for ruptured hepatocellular carcinoma controlled after transcatheter arterial embolization: case report and review of the literature. In Vivo 2018;32:659 62. doi: 10.21873/invivo.11290.

Hai S, Okada T, Iimuro Y, Hirano T, Suzumura K, Fujimoto J. Successful laparoscopic extirpation of peritoneal dissemination after hepatectomy for ruptured hepatocellular carcinoma. Asian J Endosc Surg 2015;8:465-7. doi: 10.1111/ases.12212.

Lee CY, Chau GY, Wei CY, Chao Y, Huang YH, Huo TI, et al. Surgical resection could provide better outcomes for patients with hepatocellular carcinoma and tumor rupture. Sci Rep 2022;12:8343. doi: 10.1038/s41598-022-12350-x.

Kabir T, Tan ZZX, Chua DW, Syn N, Goh BKP. Early experience with laparoscopic liver resection for spontaneously ruptured hepatocellular carcinoma. J Minim Access Surg 2020;16:239 45. doi: 10.4103/jmas.JMAS_47_19.

Khairuddin A, Ong GH, Tan JS, Johan S, Hoe VC, Sharif MS, et al. Emergency laparoscopic resection of spontaneous rupture of hepatocellular carcinoma: a case report. Int J Surg Case Rep 2020;66:104-6. doi: 10.1016/j.ijscr.2019.11.055.

Kabir T, Goh BKP. Contemporary techniques commonly adopted for performing laparoscopic liver resection. Laparosc Surg 2018;2. doi: 10.21037/ls.2018.10.11.

Hu HJ, Wu ZR, Jin YW, Ma WJ, Yang Q, Wang JK, et al. Minimally invasive surgery for hilar cholangiocarcinoma: state of art and future perspectives. ANZ J Surg 2019;89:476-80. doi: 10.1111/ans.14765.

Nguyen KT, Marsh JW, Tsung A, Steel JJ, Gamblin TC, Geller DA. Comparative benefits of laparoscopic vs open hepatic resection: a critical appraisal. Arch Surg 2011;146:348-56. doi: 10.1001/archsurg.2010.248.

Schiffman SC, Kim KH, Tsung A, Marsh JW, Geller DA. Laparoscopic versus open liver resection for metastatic colorectal cancer: a metaanalysis of 610 patients. Surgery 2015;157:211-22. doi: 10.1016/j.surg.2014.08.036.

Robles-Campos R, Lopez-Lopez V, Brusadin R, Lopez Conesa A, Gil-Vazquez PJ, Navarro-Barrios Á, et al. Open versus minimally invasive liver surgery for colorectal liver metastases (LapOpHuva): a prospective randomized controlled trial. Surg Endosc 2019;33:3926-36. doi: 10.1007/s00464-019 06679-0.

Fichtinger RS, Aldrighetti LA, Abu Hilal M, Troisi RI, Sutcliffe RP, Besselink MG, et al. Laparoscopic Versus Open Hemihepatectomy: The ORANGE II PLUS Multicenter Randomized Controlled Trial. J Clin Oncol 2024;42:1799-809. doi: 10.1200/JCO.23.01019.

Downloads

Published

2026-04-17

How to Cite

1.
Wiboonkhwan N- ak. Laparoscopic Liver Resection in Ruptured Hepatocellular Carcinoma [with Video]: Current Role of LLR in Ruptured HCC. PSU Med J [internet]. 2026 Apr. 17 [cited 2026 Apr. 20];6(1):35-43. available from: https://he01.tci-thaijo.org/index.php/PSUMJ/article/view/283806

Issue

Section

Review Articles