PSU Medical Journal 2021-04-01T13:41:03+07:00 Kamolthip Suwanthavee Open Journal Systems Admidst an Unfavorable Atmosphere, Never Lock Down Academia 2021-03-15T13:52:29+07:00 Puttisak Puttawibul 2021-03-12T00:00:00+07:00 Copyright (c) 2021 Author and Journal A Content Analysis of YouTube™ Videos Related to Bladder Cancer 2021-04-01T13:37:42+07:00 Wichaya Soonsuwon Tanan Bejrananda <p><strong>Objective:</strong> We examined the content of YouTube™ videos on urinary bladder cancer education and evaluated their usefulness in promoting early detection of the cancer. <br><strong>Material and Methods</strong>:A systematic search of YouTube™ for videos containing knowledge information on bladder cancer was conducted using the keywords ‘bladder cancer’. Details about demographics of videos, including type, length, source and viewers’ interaction were evaluated and 2 researchers independently assessed the videos for usefulness in promoting knowledge on bladder cancer.<br><strong>Results:</strong> A total of 100 YouTube™ videos (100 most viewed videos were reviewed and 48 videos were excluded including surgical technic videos, videos in non-English languages, patient testimonial videos and videos about complementary and alternative medicine. A total of 52 videos were analyzed. The highest number of videos were uploaded by medical websites (18, 34.6%), the mean number of views is highest in videos that were categorized as not useful (105,447), followed by very useful (74,940.6±120,980.8), slightly useful (46,219.6±101,261.4), moderately useful (34,941.0±35,413.1). The mean number of “likes” is highest in the very useful group (339.4±373.6), so is the “dislikes” (25.3±40.9).<br><strong>Conclusion:</strong> YouTube™ contains a diverse source of information on bladder cancer. Most videos on bladder cancer may not be informative for health education. Medical professionals, medical institutions, and professional organizations should improve the content of videos about bladder cancer to provide patients with reliable and useful information.</p> 2021-03-12T00:00:00+07:00 Copyright (c) 2021 Author and Journal Direct Cost of Anesthesia in Traumatic Patients with Massive Bleeding: a Prospective Micro-Costing Study 2021-03-15T13:54:59+07:00 Asamaporn Puetpaiboon Sunisa Chatmongkolchart Osaree Akaraborworn Yupin Apisitthiwong <p><strong>Objective:</strong>This study aimed to quantify the direct cost as well as cost-to-charge ratio of anesthetic care in traumatic patients with intraoperative massive bleeding.<br><strong>Material and Methods:</strong> This study was a prospective observational cost analysis study, conducted in Songklanagarind Hospital, Thailand. Traumatic patients from any mechanisms were recruited. Massive bleeding was defined as estimated blood loss of at least one blood volume in 24 hours or a half of blood volume in 3 hours. The cost components were valued by the bottom-up approach. The direct cost was divided into 4 categories; the labor cost, the capital cost, the material cost and the cost of drugs.<br><strong>Results: </strong>From September 2017 to August 2018; 10 eligible patients were included. Seven patients had motorcycle accidents, two patients fell from height and another one was in a minibus accident. Two patients died on the operating table, and another two died within 48 hours. The median direct cost per case was 9,321 Baht (264 United States Dollars), and the cost-to-charge ratio was 0.62. The median Sequential Organ Failure Assessment Score was 8. The median intraoperative blood loss was 3,500 millimeters.<br><strong>Conclusion:</strong> Our study provided information on the direct costs of anesthesia in traumatic patients with massive bleeding. The direct cost was 62.0% of the hospital charge. However, this study did not analyze the indirect cost. <br><br></p> 2021-03-12T00:00:00+07:00 Copyright (c) 2021 Author and Journal Neurilemoma of Seminal Vesicle: A Case Report 2021-04-01T13:39:28+07:00 Isaris Chaokamin Apiwich Anukoolphaiboon Virote Chalieopanyarwong Worapat Attawettayanon Kanin Khanungwanitkul Kamonwon Cattapan Paramee Thongsuksai <p>Neurilemmoma of the seminal vesicle is an extremely rare tumor. We report a neurilemmoma of right seminal vesicle. A 67-year-old man presented with moderate lower urinary tract symptoms. A magnetic resonance imaging of prostate performed due to high level of prostate specific antigen revealed a 8.1x8.1x7.1 cm, arising from right seminal vesicle. Laparoscopic resection of tumor was performed. The histopathology showed neurilemmoma arising from seminal vesicle.</p> <p>&nbsp;</p> 2021-03-12T00:00:00+07:00 Copyright (c) 2021 Author and Journal Personalized Treatment of 6-Mercaptopurine in Thai Children with Acute Lymphoblastic Leukemia 2021-04-01T13:40:08+07:00 Jassada Buaboonnam Kleebsabai Sanpakit Trai Tharnpanich <p>Thanks to its ability to inhibit deoxyribonucleic acid synthesis, 6-mercaptopurine (6-MP), is one of the indispensable medications for acute lymphoblastic leukemia (ALL) patients. Nevertheless, some patients may succumb to myelotoxicity, leading to treatment disruption or even life-threatening events. Owing to the advances in pharmacogenomics, the genetic polymorphism of genes regulating purine synthesis has been identified and physicians can adjust the dose of 6-MP according to each polymorphism. Such polymorphisms genetically vary among ethnicities. In this article, 2 genetic polymorphisms, namely thiopurine methyltransferase and Nudix (nucleoside diphosphate linked moiety X) type motif 15, are clinically discussed, with a special focus on the clinical studies in Thai children with ALL.</p> 2021-03-12T00:00:00+07:00 Copyright (c) 2021 Author and Journal Vitamin D: An Essential Micronutrient for Bone Health 2021-04-01T13:41:03+07:00 Somchit Jaruratanasirikul <p>Vitamin D is an essential micronutrient in children for bone mineralization and bone growth. There are two forms of natural vitamin D, vitamin D2 and vitamin D3. Natural vitamin D is obtained from 2 main sources, dietary vitamin D intake and cutaneous vitamin D synthesis from sunlight exposure. Natural vitamin D requires a 2-step enzymatic hydroxylation process to be turned into active form of 1,25-dihydroxyvitamin D, firstly, 25-hydroxylation in the liver, and secondly, 1α-hydroxylation in the kidneys. Although breast milk is highly nutritive containing adequate amounts of most important vitamins, it contains only a small amount of vitamin D, approximately 15-50 IU/L, which does not reach the recommended daily requirement of 400 IU for infants. Exclusively breastfed infants are at risk to develop vitamin D deficiency if sunlight exposure is limited. Despite the excess of sunshine for the whole year in Southeast Asian countries including Thailand, various studies have found that more than 30.0% of children and adolescents had vitamin D insufficiency. The factors associated with vitamin D insufficiency in children include maternal vitamin D deficiency, exclusively breastfed as infants, insufficient daytime outdoor activities, use of sunscreens, extensive skin coverage by clothing, and lack of vitamin D supplementation and dietary fortification. To prevent vitamin D deficiency in infants, a global consensus in 2016 recommended that vitamin D supplementation should be included in routine national health care programs along with other essential micronutrients and immunizations.</p> 2021-03-12T00:00:00+07:00 Copyright (c) 2021 Author and Journal