The Untoward Effects of COVID-19 Vaccines and Determinant Factors among Vaccinated Healthcare Workers at Public Health Facilities in Addis Ababa, Ethiopia

Authors

  • Tesfaye Desalegn Department of Public Health Research and Emergency Management, Addis Ababa Health Bureau, Addis Ababa 30738, Ethiopia.
  • Yohannes Woldkidan Department of Public Health Research and Emergency Management, Addis Ababa Health Bureau, Addis Ababa 30738, Ethiopia.
  • Zerihun Alemu Department of Public Health Research and Emergency Management, Addis Ababa Health Bureau, Addis Ababa 30738, Ethiopia.
  • Kassahun Yimam Department of Public Health Research and Emergency Management, Addis Ababa Health Bureau, Addis Ababa 30738, Ethiopia.
  • Binyam Degeffe Department of Public Health Research and Emergency Management, Addis Ababa Health Bureau, Addis Ababa 30738, Ethiopia.
  • Ulfet Abdurahman Department of Public Health Research and Emergency Management, Addis Ababa Health Bureau, Addis Ababa 30738, Ethiopia.

DOI:

https://doi.org/10.31584/psumj.2025278888

Keywords:

Addis Ababa, adverse effect, COVID-19 vaccine, healthcare worker, public health facility

Abstract

Objective: The overall objective of this study was to investigate the adverse effects of coronavirus disease 2019 (COVID-19) vaccines, and their associated factors among vaccinated health care workers working (HCWs) at public health facilities in Addis Ababa, Ethiopia: 2021/22.
Material and Methods: This study was implemented on 542 study participants found in Addis-Ababa city administration public health facilities, Addis Ababa, Ethiopia. A quantitative approach and facility-based cross-sectional study design, using proportionate allocation of the samples among each health facility, was adopted. The study used a questionnaire as a tool to collect data.
Results: Out of 542 samples, 526 study subjects participated (61.5% females): response rate was 97.05%. The proportion of HCWs having had post-COVID-19 vaccine adverse effects outcome among the study participants was 319 (60.6%, 95% confidence interval: 56.7%-64.6%). Logistic regression analysis results revealed that the odds of having history of allergic reaction to any vaccine were found 11.108 times higher (p-value<0.05), and the odds of having co-morbidity were found to have 2.299 times higher (p-value<0.05) determinant effects to develop and significantly associate with the post-COVID-19 vaccine adverse effects.
Conclusion: Experiences of post-COVID-19 vaccine adverse effects is higher and more common. Following side effects, a significant number of study participants have also undertaken treatment options to reduce post-vaccine discomforts/ pains. Additionally, individuals that have history of allergic reactions to any vaccine and co-morbidities are positively associated with post-vaccine side effects. Therefore, even though post-COVID-19 vaccine side effects are very common, the advantages of taking the vaccine outweigh its disadvantages, and vaccinated individuals can seek treatment options when they experience severe post-vaccine side effects.

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Published

2025-08-22

How to Cite

1.
Desalegn T, Woldkidan Y, Alemu Z, Yimam K, Degeffe B, Abdurahman U. The Untoward Effects of COVID-19 Vaccines and Determinant Factors among Vaccinated Healthcare Workers at Public Health Facilities in Addis Ababa, Ethiopia. PSU Med J [internet]. 2025 Aug. 22 [cited 2026 Jan. 12];5(2):61-74. available from: https://he01.tci-thaijo.org/index.php/PSUMJ/article/view/278888

Issue

Vol. 5 No. 2 (2025): May-Aug

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Original Articles

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