A Case Report Anal Gastrointestinal Stromal Tumor Presenting with Obstipation

Authors

  • Thanyaporn Kanchanasuwan Internal Medicine Department, Koh Samui Hospital, Koh Samui, Suratthani 84140, Thailand.

DOI:

https://doi.org/10.31584/psumj.2023255835

Keywords:

anal canal, endoscopic ultrasonography, gastrointestinal stromal tumor, imatinib, magnetic resonance imaging

Abstract

Gastrointestinal stromal tumor (GIST) is an uncommon gastrointestinal neoplasm with high rate of malignant transformation. The tumor is found mainly in the stomach and the small intestine, and the anorectum is an extremely rare anatomical location for this pathology. GIST is often discovered incidentally by a computerized tomography scan, endoscopy or during a laparotomy for other reasons. We describe a case of 64-year-old female with a mass in the anal canal presenting with tenesmus and difficulty defecation. Endoscopic ultrasonography and magnetic resonance imaging showed a mass at the rectum, externally compressing the vaginal wall. The patient was managed by a local excision which was preceded by an upfront therapy with imatinib. Histological examination showed proliferation of spindle cells stained with CD34 compatible with GIST. On post-operative follow-up visit, the patient did well with continuing imatinib therapy. 

References

Soreide K, Sandvik OM, Soreide JA, Giljaca V, Jureckova A, Bulusu VR. Global epidemiology of gastrointestinal stromal tumours (GIST): a systematic review of population-based cohort studies. Cancer Epidemiol 2016;40:39-46.

Parab TM, DeRogatis MJ, Boaz AM, Grasso SA, Issack PS, Duarte DA, et al. Gastrointestinal stromal tumors: a comprehensive review. J Gastrointest Oncol 2019;10:144-54.

Carvalho N, Albergaria D, Lebre R, Giria J, Fernandes V, Vidal H, et al. Anal canal gastrointestinal stromal tumors: case report and literature review. World J Gastroenterol 2014;20:319-22.

Lamba G, Gupta R, Lee B, Ambrale S, Liu D. Current management and prognostic features for gastrointestinal stromal tumor (GIST). Exp Hematol Oncol 2012;1:1-10.

Li JC, Ng SS, Lo AW, Lee JF, Yiu RY, Leung KL. Outcome of radical excision of anorectal gastrointestinal stromal tumors in Hong Kong Chinese patients. Indian J Gastroenterol 2007;26:33-5.

Tan G, Chong C, Eu K, Tan P. Gastrointestinal stromal tumor of the anus. Tech Coloproctol 2003;7:169-72.

Menge F, Jakob J, Kasper B, Smakic A, Gaiser T, Hohenberger P. Clinical presentation of gastrointestinal stromal tumors. Visc Med 2018;34:335-40.

Qu H, Xu Z, Ren Y, Gong Z, Ju RH, Zhang F, et al. Recent Advancements in the Treatment of Rectal Gastrointestinal Stromal Tumor: In Era of Imatinib. Cancer Manag Res 2022;14:1141-52.

Guo W, Yang Z, Wei Y, Qin X, Li C, Huang R, et al. Radical excision versus local resection for primary rectal gastrointestinal stromal tumors. Cohort Study. Int J Surg 2020;77:190-7.

Kaneko M, Emoto S, Murono K, Sonoda H, Hiyoshi M, Sasaki K, et al. Neoadjuvant imatinib therapy in rectal gastrointestinal stromal tumors. Surg Today 2019;49:460-6.

Kameyama H, Kanda T, Tajima Y, Shimada Y, Ichikawa H, Hanyu T, et al. Management of rectal gastrointestinal stromal tumor. Transl Gastroenterol Hepatol 2018;3:8.

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Published

2023-02-03

How to Cite

1.
Kanchanasuwan T. A Case Report Anal Gastrointestinal Stromal Tumor Presenting with Obstipation. PSU Med J [Internet]. 2023 Feb. 3 [cited 2024 May 8];3(1):21-5. Available from: https://he01.tci-thaijo.org/index.php/PSUMJ/article/view/255835

Issue

Vol. 3 No. 1 (2023): Jan-Apr

Section

Short Reports

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