Evolution and Bioinformatic Analysis of the Whole Genome Sequences of SARS-CoV-2

Variant Analysis of SARS-CoV-2 Genomes

Authors

  • Thanit Sila Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
  • Wison Laochareonsuk Department of Biomedical Sciences & Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand and Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
  • Komwit Surachart Department of Biomedical Sciences & Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
  • Samonrapat Surasombatpattana Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
  • Wanut Saelim Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand
  • Surasak Sangkhathat Translational Medicine Research Center, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand and Department of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand

DOI:

https://doi.org/10.31584/psumj.2022254705

Keywords:

Covid-19, SARS-CoV-2, Virus Genome

Abstract

Coronavirus Disease 2019 (COVID-19) disease, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, has been spreading as a pandemic and health catastrophe. The increase in the rate of infection influenced the mutation rate to increase greatly. Mutations found in the spike protein site of SARS-CoV-2 may result in changes in the binding of the angiotensin-converting enzyme 2 (ACE2) receptor in the human respiratory mucosa, which is a significant step in infection, severity, and speed of the epidemic. Scientists are now recognizing and focusing on variant of concern (VOC) that are currently spreading and affecting: Alpha, Beta, Gamma, Delta, and Omicron. Therefore, to monitor and mitigate the spread of coronavirus-19, it is imperative to understand the structure, functions, and mutation of the virus. Bioinformatics is one tool used to determine strains in the genetic code data obtained by molecular biomolecular processes such as real-time polymerase chain reaction (RT-PCR), next generation sequencing (NGS), Mass Array and others. As the COVID-19 pandemic seems not to end soon, viruses continue to evolve, and this has given them a greater potential for infection and evasion of immunity, monitoring of viral genome is crucial.

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Published

2022-05-19

How to Cite

1.
Sila T, Laochareonsuk W, Surachart K, Surasombatpattana S, Saelim W, Sangkhathat S. Evolution and Bioinformatic Analysis of the Whole Genome Sequences of SARS-CoV-2: Variant Analysis of SARS-CoV-2 Genomes. PSU Med J [Internet]. 2022 May 19 [cited 2022 Aug. 20];2(2):85-98. Available from: https://he01.tci-thaijo.org/index.php/PSUMJ/article/view/254705

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